Modeling, simulation, and flight characteristics of an aircraft designed to fly at 100,000 feet

A manned real time simulation of a conceptual vehicle, the stratoplane, was developed to study the problems associated with the flight characteristics of a large, lightweight vehicle. Mathematical models of the aerodynamics, mass properties, and propulsion system were developed in support of the simulation and are presented. The simulation was at first conducted without control augmentation to determine the needs for a control system. The unaugmented flying qualities were dominated by lightly damped dutch roll oscillations. Constant pilot workloads were needed at high altitudes. Control augmentation was studied using basic feedbacks. For the longitudinal axis, flight path angle, and pitch rate feedback were sufficient to damp the phugoid mode and to provide good flying qualities. In the lateral directional axis, bank angle, roll rate, and yaw rate feedbacks were sufficient to provide a safe vehicle with acceptable handling qualities. Intentionally stalling the stratoplane to very high angles of attack (deep stall) was studied as a means of enable safe and rapid descent. It was concluded that the deep stall maneuver is viable for this class of vehicle

Flight characteristics of the AD-1 oblique-wing research aircraft

The AD-1 is a low-speed oblique-wing research airplane. This report reviews the vehicle's basic flight characteristics, including many aerodynamic, stability, and control effects that are unique to an oblique-wing configuration. These effects include the change in sideforce with angle of attack, moment changes with angle of attack and load factor, initial stall on the trailing wing, and inertial coupling caused by a roll-pitch cross product of inertia. An assessment of the handling qualities includes pilot ratings and comments. Ratings were generally satisfactory through 30 deg of wing sweep but degraded with increased sweep. A piloted simulation study indicated that a basic rate feedback control system could be used to improve the handling qualities at higher wing sweeps

Flight characteristics of a modified Schweizer SGS1-36 sailplane at low and very high angles of attack

A manned flight research program using a modified sailplane was conducted to very high angles of attack at the NASA-Ames. Piloting techniques were established that enabled the pilot to attain and stabilize on an angle of attack in the 30 to 72 deg range. Aerodynamic derivatives were estimated from the flight data for both low and very high angles of attack and are compared to wind tunnel data. In addition, limited performance and trim data are presented

A Correlation Between Flight-Determined Derivatives and Wind-Tunnel Data for the X-24B Research Aircraft

Longitudinal and lateral-directional estimates of the aerodynamic derivatives of the X-24B research aircraft were obtained from flight data by using a modified maximum likelihooa estimation method. Data were obtained over a Mach number range from 0.35 to 1.72 and over an angle of attack range from 3.5deg to 15.7deg. Data are presented for a subsonic and a transonic configuration. The flight derivatives were generally consistent and documented the aircraft well. The correlation between the flight data and wind-tunnel predictions is presented and discussed

The development and flight test of a deployable precision landing system for spacecraft recovery

A joint NASA Dryden Flight Research Facility and Johnson Space Center program was conducted to determine the feasibility of the autonomous recovery of a spacecraft using a ram-air parafoil system for the final stages of entry from space that included a precision landing. The feasibility of this system was studied using a flight model of a spacecraft in the generic shape of a flattened biconic which weighed approximately 150 lb and was flown under a commercially available, ram-air parachute. Key elements of the vehicle included the Global Positioning System guidance for navigation, flight control computer, ultrasonic sensing for terminal altitude, electronic compass, and onboard data recording. A flight test program was used to develop and refine the vehicle. This vehicle completed an autonomous flight from an altitude of 10,000 ft and a lateral offset of 1.7 miles which resulted in a precision flare and landing into the wind at a predetermined location. At times, the autonomous flight was conducted in the presence of winds approximately equal to vehicle airspeed. Several techniques for computing the winds postflight were evaluated. Future program objectives are also presented

Further development and flight test of an autonomous precision landing system using a parafoil

NASA Dryden Flight Research Center and NASA Johnson Space Center are jointly conducting a phased program to determine the feasibility of the autonomous recovery of a spacecraft using a ram-air parafoil system for the final stages of entry from space to a precision landing. The feasibility is being studied using a flight model of a spacecraft in the generic shape of a flattened biconic that weighs approximately 120 lb and is flown under a commercially available ram-air parafoil. Key components of the vehicle include the global positioning system (GPS) guidance for navigation, a flight control computer, an electronic compass, a yaw rate gyro, and an onboard data recorder. A flight test program is being used to develop and refine the vehicle. The primary flight goal is to demonstrate autonomous flight from an altitude of 3,000 m (10,000 ft) with a lateral offset of 1.6 km (1.0 mi) to a precision soft landing. This paper summarizes the progress to date. Much of the navigation system has been tested, including a heading tracker that was developed using parameter estimation techniques and a complementary filter. The autoland portion of the autopilot is still in development. The feasibility of conducting the flare maneuver without servoactuators was investigated as a means of significantly reducing the servoactuator rate and load requirements

Improving the Quality of Dentistry (IQuaD):a cluster factorial randomised controlled trial comparing the effectiveness and cost-benefit of oral hygiene advice and/or periodontal instrumentation with routine care for the prevention and management of periodontal disease in dentate adults attending dental primary care

Acknowledgements The authors wish to thank Mark Forrest and the programming team at CHaRT; Cynthia Fraser, our information specialist, for assistance with referencing; Moira Swan, who was the dental research nurse and part of the OA team in Newcastle upon Tyne; Louise Campbell for secretarial support and data management; our original statistician in the group, Andy Elders; senior IT manager Gladys Macpherson; senior trial administrator at the TCOD Marilyn Laird; Luke Vale for his involvement with the design of the health economic analysis at the inception of the trial; Maria Dimitrova, who assisted the health economists in the collection of unit costs; staff of the Scottish Primary Care Research Network, who assisted with screening eligible patients at dental practices; staff of the North East Commissioning Support Unit who assisted with research payments to dental practices in the north-east; members of the TMC and Periodontal Advisory Group for their ongoing advice and support of the trial; the independent members of the TSC and DMC; and the staff at recruitment sites who facilitated recruitment, treatment and follow-up of trial participants. The Health Services Research Unit and the Health Economics Research Unit is core funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorate.Peer reviewedPublisher PD

Biological, clinical and population relevance of 95 loci for blood lipids.

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P < 5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD