2,103 research outputs found
Predictive context biases perceptual selection during binocular rivalry
Prediction may be a fundamental principle of sensory processing, such that the brain continuously generates predictions about forthcoming sensory information. However, little is known about how prediction contributes to the selection of a conscious percept from among competing alternatives. Here, we used binocular rivalry to investigate the effects of prediction on perceptual selection. In binocular rivalry, incompatible images presented to the two eyes result in a perceptual alternation between the images, even though the visual stimuli remain constant. If predictive signals influence the competition between neural representations of rivalrous images, this influence should generate a bias in perceptual selection that depends on predictive context. To manipulate predictive context, we developed a novel binocular rivalry paradigm in which orthogonal rivalrous test gratings were immediately preceded by rotating gratings presented identically to the two eyes. One of the rivalrous gratings had an orientation that was consistent with the preceding rotation direction (it was the expected next image in the series), and the other had an inconsistent orientation. We found that human observers were more likely to perceive the consistent grating, suggesting that predictive context biased selection in favor of the predicted percept. This prediction effect depended on only recent stimulus history, and it could be dissociated from another stimulus history effect related to orientation-specific adaptation. Since binocular rivalry between orthogonal gratings is thought to be resolved at an early stage of visual processing, these results suggest that predictive signals may exist at low levels of the visual processing hierarchy and that these signals can bias conscious perception. In the future, this paradigm could be used to test whether visual percepts are generated from the combination of prior information and incoming sensory information according to Bayesian principles
Predictive Context Influences Perceptual Selection during Binocular Rivalry
Prediction may be a fundamental principle of sensory processing: it has been proposed that the brain continuously generates predictions about forthcoming sensory information. However, little is known about how prediction contributes to the selection of a conscious percept from among competing alternatives. Here, we used binocular rivalry to investigate the effects of prediction on perceptual selection. In binocular rivalry, incompatible images presented to the two eyes result in a perceptual alternation between the images, even though the visual stimuli remain constant. If predictive signals influence the competition between neural representations of rivalrous images, this influence should generate a bias in perceptual selection that depends on predictive context. To manipulate predictive context, we developed a novel binocular rivalry paradigm in which rivalrous test images were immediately preceded by a sequence of context images presented identically to the two eyes. One of the test images was consistent with the preceding image sequence (it was the expected next image in the series), and the other was inconsistent (non-predicted). We found that human observers were more likely to perceive the consistent image at the onset of rivalry, suggesting that predictive context biased selection in favor of the predicted percept. This prediction effect was distinct from the effects of adaptation to stimuli presented before the binocular rivalry test. In addition, perceptual reports were speeded for predicted percepts relative to non-predicted percepts. These results suggest that predictive signals related to visual stimulus history exist at neural sites that can bias conscious perception during binocular rivalry. Our paradigm provides a new way to study how prior information and incoming sensory information combine to generate visual percepts
Efficacy of a 4-part program on brain development
OBJECTIVES/SPECIFIC AIMS: (1) Provide basic brain knowledge about development and resiliency. (2) Develop an understanding of how a mother can impact a childās brain development. (3) Foster a sense of agency to increase the likelihood that a mother will enact positive changes. (4) Develop the ability to recognize a connection between oneās own behaviors and a childās development and behaviors. METHODS/STUDY POPULATION: Tested the efficacy of a 4-week intervention program on neurodevelopment for homeless mothers. Mothers (n=4) residing at the Center for the Homeless in South Bend, IN were recruited. Used community partner feedback, weekly surveys, and pre/post tests to look at changes in basic content knowledge, behavioral change, and self-efficacy. RESULTS/ANTICIPATED RESULTS: Preliminary results indicate an increase in knowledge about neurodevelopment, although results on behavioral changes are inconclusive. The program is anticipated to run a second time with a new group of parents residing in the Center for the Homeless to increase sample size. DISCUSSION/SIGNIFICANCE OF IMPACT: Anticipated that the results will add to the existing literature concerning effective interventions in strengthening parenting and neuroscience knowledge in vulnerable populations
Social pedagogy: historical traditions and transnational connections
With over 150 years of history, social pedagogy is both an interdisciplinary scholarly field of inquiry and a field of practice that is situated in the intersection of three areas of human activity: education, social work and community development. Although social pedagogy has different emphases and approaches depending on particular historical and geographical contexts, a common theme is that it deals with the connections between educational and social dynamics, or put in a different way, it is concerned with the educational dimension of social issues and the social dimensions of educational issues. The first part of this paper analyzes the history of the field of social pedagogy since its origins until today, with a focus on transnational flows between Europe and the Americas. The second part of the paper discusses the main issues raised in this special issue of EPAA, and extracts the main threads and connections among the different papers included in the volume
Broader Visual Orientation Tuning in Patients with Schizophrenia
Reduced gamma-aminobutyric acid (GABA) levels in cerebral cortex are thought to contribute to information processing deficits in patients with schizophrenia (SZ), and we have previously reported lower in vivo GABA levels in the visual cortex of patients with SZ. GABA-mediated inhibition plays a role in sharpening orientation tuning of visual cortical neurons. Therefore, we predicted that tuning for visual stimulus orientation would be wider in SZ. We measured orientation tuning with a psychophysical procedure in which subjects performed a target detection task of a low-contrast oriented grating, following adaptation to a high-contrast grating. Contrast detection thresholds were determined for a range of adapterātarget orientation offsets. For both SZ and healthy controls, contrast thresholds decreased as orientation offset increased, suggesting that this tuning curve reflects the selectivity of visual cortical neurons for stimulus orientation. After accounting for generalized deficits in task performance in SZ, there was no difference between patients and controls for detection of target stimuli having either the same orientation as the adapter or orientations far from the adapter. However, patientsā thresholds were significantly higher for intermediate adapterātarget offsets. In addition, the mean width parameter of a Gaussian fit to the psychophysical orientation tuning curves was significantly larger for the patient group. We also present preliminary data relating visual cortical GABA levels, as measured with magnetic resonance spectroscopy, and orientation tuning width. These results suggest that our finding of broader orientation tuning in SZ may be due to diminished visual cortical GABA levels
Cells from Xenopus laevis Gastrulae Adhere to Fibronectin-Sepharose Beads and Other Lectin Coated Beads
Cells from Xenopus laevis blastulae have a poorly developed ability to adhere to Sepharose beads covalently coupled to bovine plasma fibronectin (FN-beads). They do, however, have the ability to adhere to con A-beads and cytodex-1 and cytodex-3 beads. Beginning at the early gastrula stage, there is a progressively increasing ability of cells to adhere to FN-beads. Gastrula cells adhere to FN-beads by the formation of large ruffling lamellipodia. These cells can translocate on the surface of FN-beads; and when attached to both beads and the surrounding glass substratum of culture vessels, have the ability to move the beads extensively. Gastrula cells also have the ability to adhere to but not move upon con A-beads, wheat germ agglutinin-beads, and soy bean agglutinin-beads. They do not adhere significantly to Tetragonolobus purpureas agglutinin-beads. These results suggest that there are increasing numbers of fibronectin receptors present on the surface of embryonic amphibian cells during the period of gastrulation. They may explain the differential distribution of fibronectin-containing fibrils in vivo as observed by scanning electron microscopy
An Algorithm for Motion Estimation from the Tomographic Data
In this paper we study local tomography (LT) in the motion contaminated case. It is shown that microlocally, away from some critical directions, LT is equivalent to a pseudo-differential operator of order one. LT also produces non-local artifacts that are of the same strength as useful singularities. If motion is not accurately known, singularities inside the object f being scanned spread in different directions. A single edge can become a double edge. In such a case the image of f looks cluttered. Based on this observation we propose an algorithm for motion estimation. We propose an empiric measure of image clutter, which we call edge entropy. By minimizing edge entropy we find the motion model. The algorithm is quite flexible and is used also for solving the misalignment correction problem. The results of numerical experiments on motion estimation and misalignment correction are very encouraging
Method for Estimating Scan Parameters from Tomographic Data
In this paper we study local tomography (LT) in the motion contaminated case. It is shown that microlocally, away from some critical directions, LT is equivalent to a pseudo-differential operator of order one. LT also produces non-local artifacts that are of the same strength as useful singularities. If motion is not accurately known, singularities inside the object f being scanned spread in different directions. A single edge can become a double edge. In such a case the image of f looks cluttered. Based on this observation we propose an algorithm for motion estimation. We propose an empiric measure of image clutter, which we call edge entropy. By minimizing edge entropy we find the motion model. The algorithm is quite flexible and is used also for solving the misalignment correction problem. The results of numerical experiments on motion estimation and misalignment correction are very encouraging
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