Meconium microbiome and its relation to neonatal growth and head circumference catch-up in preterm infants

The purpose was identify an association between meconium microbiome, extra-uterine growth restriction, and head circumference catch-up. Materials and methods: Prospective study with preterm infants born <33 weeks gestational age (GA), admitted at Neonatal Unit and attending the Follow-Up Preterm Program of a tertiary hospital. Excluded out born infants; presence of congenital malformations or genetic syndromes; congenital infections; HIV-positive mothers; and newborns whose parents or legal guardians did not authorize participation. Approved by the institution’s ethics committee. Conducted 16S rRNA sequencing using PGM Ion Torrent meconium samples for microbiota analysis. Results: Included 63 newborns, GA 30±2.3 weeks, mean weight 1375.80±462.6 grams, 68.3% adequate weight for GA at birth. Polynucleobacter (p = 0.0163), Gp1 (p = 0.018), and Prevotella (p = 0.038) appeared in greater abundance in meconium of preterm infants with adequate birth weight for GA. Thirty (47.6%) children reached head circumference catch-up before 6 months CA and 33 (52.4%) after 6 months CA. Salmonella (p<0.001), Flavobacterium (p = 0.026), and Burkholderia (p = 0.026) were found to be more abundant in meconium in the group of newborns who achieved catch-up prior to 6th month CA. Conclusion: Meconium microbiome abundance was related to adequacy of weight for GA. Meconium microbiome differs between children who achieve head circumference catch-up by the 6th month of corrected age or after this period

3‑Aminopropyl-triethoxysilane-Functionalized Tannin-Rich Grape Biomass for the Adsorption of Methyl Orange Dye: Synthesis, Characterization, and the Adsorption Mechanism

A biomass amino silica-functionalized material was successfully prepared by a simple sol–gel method. 3-Aminopropyltriethoxysilane (APTES) was added to a tannin-rich grape residue to improve its physicochemical properties and enhance the adsorption performance. The APTES functionalization led to significant changes in the material’s characteristics. The functionalized material was efficiently applied in the removal of methyl orange (MO) due to its unique characteristics, such as an abundance of functional groups on its surface. The adsorption process suggests that the electrostatic interactions were the main acting mechanism of the MO dye removal, although other interactions can also take place. The functionalized biomass achieved a very high MO dye maximum adsorption capacity (Qmax) of 361.8 mg g–1. The temperature positively affected the MO removal, and the thermodynamic studies indicated that the adsorption of MO onto APTES-functionalized biomass was spontaneous and endothermic, and enthalpy is driven in the physisorption mode. The regeneration performance revealed that the APTES-functionalized biomass material could be easily recycled and reused by maintaining very good performance even after five cycles. The adsorbent material was also employed to treat two simulated dye house effluents, which showed 48% removal. At last, the APTES biomass-based material may find significant applications as a multifunctional adsorbent and can be used further to separate pollutants from wastewater

Power line electrocution as an overlooked threat to Lear's Macaw (Anodorhynchus leari)

Electrocution can pose a serious threat to large birds, particularly threatened species with low population sizes. However, few studies have focused on the impacts of electrocution on large parrots such as the Endangered Lear's Macaw Anodorhynchus leari, endemic to the Brazilian Caatinga. Here, we compile and describe 31 electrocution events, as reported by villagers, indicating that electrocution may be an important threat to Lear's Macaw. We suggest a research and monitoring agenda to better understand the spatial and temporal patterns of this impact and recommend some immediate mitigation measures for decreasing electrocutions.info:eu-repo/semantics/submittedVersio

Crise sócioeconômica e processo de trabalho : à busca de uma relação teórica

Acesso ao livro na íntegra no endereço: http://acesso.mte.gov.br/data/files/8A7C816A2E7311D1012FEAA3403E09B2/TrabalhonaCapital.pdf.Este capítulo propõe-se a explorar questões como estas e suscitar hipóteses sobre a relação teórica das crises capitalistas com mudanças na organização do processo de trabalho, entendidas como tentativas de reorganizar o trabalho em função da crise, estratégias que permitam ao capital contornar a crise e voltar a trilhar os caminhos da acumulação, conduzindo possivelmente a novas formas de exploração do trabalho e de produção da mais-valia absoluta e relativa

Hydrogen peroxide production regulates the mitochondrial function in insulin resistant muscle cells: Effect of catalase overexpression

AbstractThe mitochondrial redox state plays a central role in the link between mitochondrial overloading and insulin resistance. However, the mechanism by which the ROS induce insulin resistance in skeletal muscle cells is not completely understood. We examined the association between mitochondrial function and H2O2 production in insulin resistant cells. Our hypothesis is that the low mitochondrial oxygen consumption leads to elevated ROS production by a mechanism associated with reduced PGC1α transcription and low content of phosphorylated CREB. The cells were transfected with either the encoded sequence for catalase overexpression or the specific siRNA for catalase inhibition. After transfection, myotubes were incubated with palmitic acid (500μM) and the insulin response, as well as mitochondrial function and fatty acid metabolism, was determined. The low mitochondrial oxygen consumption led to elevated ROS production by a mechanism associated with β-oxidation of fatty acids. Rotenone was observed to reduce the ratio of ROS production. The elevated H2O2 production markedly decreased the PGC1α transcription, an effect that was accompanied by a reduced phosphorylation of Akt and CREB. The catalase transfection prevented the reduction in the phosphorylated level of Akt and upregulated the levels of phosphorylated CREB. The mitochondrial function was elevated and H2O2 production reduced, thus increasing the insulin sensitivity. The catalase overexpression improved mitochondrial respiration protecting the cells from fatty acid-induced, insulin resistance. This effect indicates that control of hydrogen peroxide production regulates the mitochondrial respiration preventing the insulin resistance in skeletal muscle cells by a mechanism associated with CREB phosphorylation and β-oxidation of fatty acids

Swimming exercise modifies oxidative stress in skeletal and cardiac muscles of diabetic rats

Introduction: Oxidative stress is a key factor leading to the deterioration of diabetes. Oxidative stress exacerbates diabetes and induction of the activity of the antioxidant system may be required to prevent this effect. Objetive: The aim of the present study was to evaluate the redox state in the skeletal and cardiac muscles in a diabetes rat model subjected to swimming exercise for 4 weeks. Methods: Wistar rats were divided into four groups: untrained control (C), trained control (T), untrained alloxan-induced diabetes (D), and trained alloxan-induced diabetes (TD). The redox state of the skeletal and cardiac muscles was assessed by analyzing TBARS, -SH groups, H2O2 production, and SOD and catalase activity. The total number of cardiomyocytes and the total area of collagen fibers in the cardiac muscle were measured by histomorphometry. Results: In the Soleus muscles, the TD group showed increased H2O2 levels and catalase activity compared to the T group, and SOD activity compared to the D group. Regarding the red gastrocnemius, the TD group presented higher SOD and lower catalase activities than the D group. Regarding the cardiac muscle, the TD group presented lower TBARS and higher levels of -SH groups and catalase activity than the D group. Swimming exercise decreased hyperglycemia and reduced pathology, as evidenced by the reduced number of cardiomyocytes and the area of collagen fibers. Conclusion: Swimming exercise in diabetic rats controlled hyperglycemia and oxidative damage, and the reduced fibrosis in the cardiac muscle of diabetic rats

"A Nova Eletricidade: Aplica\c{c}\~oes, Riscos e Tend\^encias da IA Moderna -- "The New Electricity": Applications, Risks, and Trends in Current AI

The thought-provoking analogy between AI and electricity, made by computer scientist and entrepreneur Andrew Ng, summarizes the deep transformation that recent advances in Artificial Intelligence (AI) have triggered in the world. This chapter presents an overview of the ever-evolving landscape of AI, written in Portuguese. With no intent to exhaust the subject, we explore the AI applications that are redefining sectors of the economy, impacting society and humanity. We analyze the risks that may come along with rapid technological progress and future trends in AI, an area that is on the path to becoming a general-purpose technology, just like electricity, which revolutionized society in the 19th and 20th centuries. A provocativa compara\c{c}\~ao entre IA e eletricidade, feita pelo cientista da computa\c{c}\~ao e empreendedor Andrew Ng, resume a profunda transforma\c{c}\~ao que os recentes avan\c{c}os em Intelig\^encia Artificial (IA) t\^em desencadeado no mundo. Este cap\'itulo apresenta uma vis\~ao geral pela paisagem em constante evolu\c{c}\~ao da IA. Sem pretens\~oes de exaurir o assunto, exploramos as aplica\c{c}\~oes que est\~ao redefinindo setores da economia, impactando a sociedade e a humanidade. Analisamos os riscos que acompanham o r\'apido progresso tecnol\'ogico e as tend\^encias futuras da IA, \'area que trilha o caminho para se tornar uma tecnologia de prop\'osito geral, assim como a eletricidade, que revolucionou a sociedade dos s\'eculos XIX e XX.Comment: In Portugues