41 research outputs found
Caracterização molecular de populaçÔes do nematĂłide-de-cisto-da-soja com diferentes Ăndices de parasitismo na cultivar Hartwig
Caracterização dos idosos usuĂĄrios de medicação residentes em instituição de longa permanĂȘncia
Introduction of the rd29A: AtDREB2A CA gene into soybean (Glycine max L. Merril) and its molecular characterization in leaves and roots during dehydration
Central Exercise Action Increases the AMPK and mTOR Response to Leptin
AMP-activated protein kinase (AMPK) and mammalian Target of Rapamycin (mTOR) are key regulators of cellular energy balance and of the effects of leptin on food intake. Acute exercise is associated with increased sensitivity to the effects of leptin on food intake in an IL-6-dependent manner. To determine whether exercise ameliorates the AMPK and mTOR response to leptin in the hypothalamus in an IL-6-dependent manner, rats performed two 3-h exercise bouts, separated by one 45-min rest period. Intracerebroventricular IL-6 infusion reduced food intake and pretreatment with AMPK activators and mTOR inhibitor prevented IL-6-induced anorexia. Activators of AMPK and fasting increased food intake in control rats to a greater extent than that observed in exercised ones, whereas inhibitor of AMPK had the opposite effect. Furthermore, the reduction of AMPK and ACC phosphorylation and increase in phosphorylation of proteins involved in mTOR signal transduction, observed in the hypothalamus after leptin infusion, were more pronounced in both lean and diet-induced obesity rats after acute exercise. Treatment with leptin reduced food intake in exercised rats that were pretreated with vehicle, although no increase in responsiveness to leptin-induced anorexia after pretreatment with anti-IL6 antibody, AICAR or Rapamycin was detected. Thus, the effects of leptin on the AMPK/mTOR pathway, potentiated by acute exercise, may contribute to appetite suppressive actions in the hypothalamus
2 nd Brazilian Consensus on Chagas Disease, 2015
Abstract Chagas disease is a neglected chronic condition with a high burden of morbidity and mortality. It has considerable psychological, social, and economic impacts. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based on the available scientific evidence. The consensus is based on the articulation and strategic contribution of renowned Brazilian experts with knowledge and experience on various aspects of the disease. It is the result of a close collaboration between the Brazilian Society of Tropical Medicine and the Ministry of Health. It is hoped that this document will strengthen the development of integrated actions against Chagas disease in the country, focusing on epidemiology, management, comprehensive care (including families and communities), communication, information, education, and research
ESTRATĂGIA SAĂDE DA FAMĂLIA E USO RACIONAL DE MEDICAMENTOS: O TRABALHO DOS AGENTES COMUNITĂRIOS EM PALMAS (TO)
Quantitative differential expression of alpha and beta ryanodine receptor genes in PSE (Pale, Soft, Exudative) meat from two chicken lines: broiler and layer
Segurança do paciente no uso de medicamentos após a alta hospitalar: estudo exploratório1
No Brasil, sĂŁo escassos os estudos sobre estratĂ©gias para a segurança do paciente no processo de uso de medicamentos apĂłs a alta hospitalar, o que dificulta o conhecimento sobre a atuação de hospitais brasileiros nessa ĂĄrea. Neste artigo, buscou-se compreender a dinĂąmica e os desafios do cuidado fornecido ao paciente pela equipe hospitalar, visando Ă segurança no processo de uso de medicamentos apĂłs a alta hospitalar. Realizou-se pesquisa exploratĂłria por meio de entrevistas com mĂ©dicos, enfermeiros, farmacĂȘuticos e assistentes sociais do Hospital UniversitĂĄrio da Universidade de SĂŁo Paulo. Foram pesquisadas as atividades de cuidado com a farmacoterapia durante e apĂłs a hospitalização, incluindo o acesso a medicamentos apĂłs alta, a existĂȘncia de articulação do hospital com outros serviços de saĂșde, e barreiras para desenvolver essas atividades. A principal estratĂ©gia adotada Ă© a orientação de alta, realizada de forma estruturada, principalmente para cuidadores de pacientes pediĂĄtricos. Em situaçÔes especĂficas, ocorre mobilização da equipe para viabilização do acesso a medicamentos prescritos na alta. Reconciliação medicamentosa estĂĄ em fase de implantação, e visita domiciliar Ă© realizada apenas para pacientes crĂticos com problemas de locomoção. As principais barreiras identificadas foram insuficiĂȘncia de recursos humanos e falta de tecnologias de informação. Conclui-se que sĂŁo desenvolvidas algumas estratĂ©gias, porĂ©m com limitaçÔes e sem articulação adequada com outros serviços de saĂșde para a continuidade do cuidado. Isto sugere a necessidade de concentração de esforços para transpor as barreiras identificadas, contribuindo para a segurança do paciente na interface entre hospital, atenção bĂĄsica e domicĂlio