COVAD survey 2 long-term outcomes: unmet need and protocol

Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, and antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy to manage pandemic. Although none of the currently approved vaccines are live-attenuated, several reports of disease flares, waning protection, and acute-onset syndromes have emerged as short-term adverse events after vaccination. Hence, scientific literature falls short when discussing potential long-term effects in vulnerable cohorts. The COVAD-2 survey follows on from the baseline COVAD-1 survey with the aim to collect patient-reported data on the long-term safety and tolerability of COVID-19 vaccines in immune modulation. The e-survey has been extensively pilot-tested and validated with translations into multiple languages. Anticipated results will help improve vaccination efforts and reduce the imminent risks of COVID-19 infection, especially in understudied vulnerable groups

Correlation Between Maxillary Central Incisor Crown Morphology And Mandibular Dental Arch Form In Normal Occlusion Subjects

The aim of this study was to evaluate the correlation between the morphology of the mandibular dental arch and the maxillary central incisor crown. Cast models from 51 Caucasian individuals, older than 15 years, with optimal occlusion, no previous orthodontic treatment, featuring 4 of the 6 keys to normal occlusion by Andrews (the first being mandatory) were observed. The models were digitalized using a 3D scanner, and images of the maxillary central incisor and mandibular dental arch were obtained. These were printed and placed in an album below pre-set models of arches and dental crowns, and distributed to 12 dental surgeons, who were asked to choose which shape was most in accordance with the models and crown presented. The Kappa test was performed to evaluate the concordance among evaluators while the chi-square test was used to verify the association between the dental arch and central incisor morphology, at a 5% significance level. The Kappa test showed moderate agreement among evaluators for both variables of this study, and the chi-square test showed no significant association between tooth shape and mandibular dental arch morphology. It may be concluded that the use of arch morphology as a diagnostic method to determine the shape of the maxillary central incisor is not appropriate. Further research is necessary to assess tooth shape using a stricter scientific basis.232149153Basciftci, F.A., Uysal, T., Buyukerkmen, A., Demir, A., The influence of extraction treatment on Holdaway soft-tissue measurements (2004) Angle Orthod, 2, pp. 167-173Paranhos, L.R., Jóias, R.P., Velasco, L., Bérzin, F., Daruge Júnior, E., Prevalence of the different maxilary central incisor in individuals with natural normal occlusion (2010) Braz J Oral Sci, 2, pp. 104-107Mossey, P.A., The heritability of malocclusion: Part 1-Genetics, principles and terminology (1999) Br J Orthod, 2, pp. 103-113Mossey, P.A., The heritability of malocclusion: Part 2-The influence of genetics in malocclusion (1999) Br J Orthod, 3, pp. 195-203Williams, J.L., A new classification of human tooth forms, with special reference to a new system of artificial teeth (1914) Dental Cosmos, 5, pp. 627-628Engelmeier, R.L., Complete-denture esthetics (1996) Dent Clin North Am, 1, pp. 71-84Landis, J.R., Koch, G.G., The measurement of observer agreement for categorical data (1977) Biometrics, 1, pp. 159-174Guldag, M.U., Buyukkaplan, E.U.A., Sentut, F., Ceylan, G., Relationship between pterygomaxillary notches and maxillary anterior teeth (2010) J Prosthodont, 19, pp. 231-234Mahshid, M., Khoshvaghti, A., Varshosaz, M., Vallaei, N., Evaluation of "golden proportion" in individuals with an esthetic smile (2004) J Esthet Restor Dent, 3, pp. 185-192. , discussion 93Petricević, N., Katunarić, M., Mehulić, K., Simeon, P., Rener-Sitar, K., Celebić, A., Selection of appropriate artificial frontal teeth size using dimensions of hard palate (2006) Coll Antropol, 30, pp. 573-577Burris, B.G., Harris, E.F., Maxillary arch size and shape in American blacks and whites (2000) Angle Orthod, 4, pp. 297-302Collins, B.P., Harris, E.F., Arch form in American blacks and whites with malocclusions (1998) J Tenn Dent Assoc, 1, pp. 15-18Sellen, P.N., Jagger, D.C., Harrison, A., Computer-generated study of the correlation between tooth, face, arch forms, and palatal contour (1998) J Prosthet Dent, 2, pp. 163-168Anderson, K.M., Behrents, R.G., McKinney, T., Buschang, P.H., Tooth shape preferences in an esthetic smile (2005) Am J Orthod Dentofacial Orthop, 4, pp. 458-465Al-Khatib, A.R., Rajion, Z.A., Masudi, S.M., Hassan, R., Anderson, P.J., Townsend, G.C., Tooth size and dental arch dimensions: A stereophotogrammetric study in Southeast Asian Malays (2011) Orthod Craniofac Res, 14, pp. 243-253Jon, L.Y.T.C., Morante, D.R.H., Bernabé, E., Vich, M.O.L., Cotrina, L.A.D., Esthetic perception towards different combinations of facial contours and upper incisor shape (2009) Braz J Oral Sci, 4, pp. 193-196Izard, G., New method for the determination of the normal artch by the function of the face (1927) Int J Orthod, 13, pp. 582-595Kageyama, T., Dominguez-Rodríguez, G.C., Vigorito, J.W., Deguchi, T., A morphological study of the relationship between arch dimensions and craniofacial structures in adolescents with Class II Division 1 malocclusions and various facial types (2006) Am J Orthod Dentofacial Orthop, 3, pp. 368-375Ricketts, R., Provocations and perceptions in cranio-facial orthopedics, dental science and facial art (1989) Denver: Rocky Mountain OrthodonticsLee, S.J., Lee, S., Lim, J., Parque, H.J., Wheeler, T.T., Method to classify dental arch forms (2011) Am J Orthod Dentofacial Orthop, 140, pp. 87-96Ferrario, V.F., Sforza, C., Colombo, A., Carvajal, R., Duncan, V., Palomino, H., Dental arch size in healthy human permanent dentitions: Ethnic differences as assessed by discriminant analysis (1999) Int J Adult Orthodon Orthognath Surg, 2, pp. 153-162Nojima, K., McLaughlin, R.P., Isshiki, Y., Sinclair, P.M., A comparative study of Caucasian and Japanese mandibular clinical arch forms (2001) Angle Orthod, 3, pp. 195-200Berksun, S., Hasanreisoglu, U., Gokdeniz, B., Computer-based evaluation of gender identification and morphologic classification of tooth face and arch forms (2002) J Prosthet Dent, 6, pp. 578-584House, M., Loop, J.L., (1937) Form and color harmony in the dental arch [monograph], , Whittier: CaliforniaSears, V.H., Selection of anterior teeth for artificial denture (1941) J Am Dent Assoc, 28, pp. 929-93

Experimental illumination of a forest: no effects of lights of different colours on the onset of the dawn chorus in songbirds

Light pollution is increasing exponentially, but its impact on animal behaviour is still poorly understood. For songbirds, the most repeatable finding is that artificial night lighting leads to an earlier daily onset of dawn singing. Most of these studies are, however, correlational and cannot entirely dissociate effects of light pollution from other effects of urbanization. In addition, there are no studies in which the effects of different light colours on singing have been tested. Here, we investigated whether the timing of dawn singing in wild songbirds is influenced by artificial light using an experimental set-up with conventional street lights. We illuminated eight previously dark forest edges with white, green, red or no light, and recorded daily onset of dawn singing during the breeding season. Based on earlier work, we predicted that onset of singing would be earlier in the lighted treatments, with the strongest effects in the early-singing species. However, we found no significant effect of the experimental night lighting (of any colour) in the 14 species for which we obtained sufficient data. Confounding effects of urbanization in previous studies may explain these results, but we also suggest that the experimental night lighting may not have been strong enough to have an effect on singing