Interactions between angiotensin-(1-7), kinins, and angiotensin II in kidney and blood vessels

The heptapeptide angiotensin (Ang)-(1-7) is currently considered one of the biologically active end products of the renin-angiotensin system. The formation of Ang-(1-7) by pathways independent of Ang II generation, the selectivity of its actions, and its peculiar property of exhibiting effects that are partially opposite of those of the parent compound, Ang II, confer a unique biochemical and functional profile to this peptide. In this article, we will review novel aspects of the biological actions of Ang-(1-7), dealing with its interaction with Ang II and kinins, especially in the kidney and blood vessels.Univ Fed Minas Gerais, Fac Med, Dept Pediat, Belo Horizonte, MG, BrazilUniv Fed Minas Gerais, Lab Hipertensao, Inst Ciencias Biol, Belo Horizonte, MG, BrazilUniv Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, BrazilMax Delbruck Ctr Mol Med, Berlin, GermanyUniv Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, BrazilWeb of Scienc

Immune status of patients with haemophilia A before exposure to factor VIII: first results from the HEMFIL study

Clinical epidemiolog