292 research outputs found
Extracting spectral density function of a binary composite without a-priori assumption
The spectral representation separates the contributions of geometrical
arrangement (topology) and intrinsic constituent properties in a composite. The
aim of paper is to present a numerical algorithm based on the Monte Carlo
integration and contrainted-least-squares methods to resolve the spectral
density function for a given system. The numerical method is verified by
comparing the results with those of Maxwell-Garnett effective permittivity
expression. Later, it is applied to a well-studied rock-and-brine system to
instruct its utility. The presented method yields significant microstructural
information in improving our understanding how microstructure influences the
macroscopic behaviour of composites without any intricate mathematics.Comment: 4 pages, 5 figures and 1 tabl
Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants
Objective: To investigate the association of grip strength with disease specific incidence and mortality and whether grip strength enhances the prediction ability of an established office based risk score.
Design: Prospective population based study.
Setting: UK Biobank.
Participants: 502 293 participants (54% women) aged 40-69 years.
Main outcome measures: All cause mortality as well as incidence of and mortality from cardiovascular disease, respiratory disease, chronic obstructive pulmonary disease, and cancer (all cancer, colorectal, lung, breast, and prostate).
Results: Of the participants included in analyses, 13 322 (2.7%) died over a mean of 7.1 (range 5.3-9.9) years’ follow-up. In women and men, respectively, hazard ratios per 5 kg lower grip strength were higher (all at P<0.05) for all cause mortality (1.20, 95% confidence interval 1.17 to 1.23, and 1.16, 1.15 to 1.17) and cause specific mortality from cardiovascular disease (1.19, 1.13 to 1.25, and 1.22, 1.18 to 1.26), all respiratory disease (1.31, 1.22 to 1.40, and 1.24, 1.20 to 1.28), chronic obstructive pulmonary disease (1.24, 1.05 to 1.47, and 1.19, 1.09 to 1.30), all cancer (1.17, 1.13 to 1.21, 1.10, 1.07 to 1.13), colorectal cancer (1.17, 1.04 to 1.32, and 1.18, 1.09 to 1.27), lung cancer (1.17, 1.07 to 1.27, and 1.08, 1.03 to 1.13), and breast cancer (1.24, 1.10 to 1.39) but not prostate cancer (1.05, 0.96 to 1.15). Several of these relations had higher hazard ratios in the younger age group. Muscle weakness (defined as grip strength <26 kg for men and <16 kg for women) was associated with a higher hazard for all health outcomes, except colon cancer in women and prostate cancer and lung cancer in both men and women. The addition of handgrip strength improved the prediction ability, based on C index change, of an office based risk score (age, sex, diabetes diagnosed, body mass index, systolic blood pressure, and smoking) for all cause (0.013) and cardiovascular mortality (0.012) and incidence of cardiovascular disease (0.009).
Conclusion: Higher grip strength was associated with a range of health outcomes and improved prediction of an office based risk score. Further work on the use of grip strength in risk scores or risk screening is needed to establish its potential clinical utility
Signs of low frequency dispersions in disordered binary dielectric mixtures (50-50)
Dielectric relaxation in disordered dielectric mixtures are presented by
emphasizing the interfacial polarization. The obtained results coincide with
and cause confusion with those of the low frequency dispersion behavior. The
considered systems are composed of two phases on two-dimensional square and
triangular topological networks. We use the finite element method to calculate
the effective dielectric permittivities of randomly generated structures. The
dielectric relaxation phenomena together with the dielectric permittivity
values at constant frequencies are investigated, and significant differences of
the square and triangular topologies are observed. The frequency dependent
properties of some of the generated structures are examined. We conclude that
the topological disorder may lead to the normal or anomalous low frequency
dispersion if the electrical properties of the phases are chosen properly, such
that for ``slightly'' {\em reciprocal mixture}--when , and
--normal, and while for ``extreme'' {\em reciprocal
mixture}--when , and --anomalous
low frequency dispersions are obtained. Finally, comparison with experimental
data indicates that one can obtain valuable information from simulations when
the material properties of the constituents are not available and of
importance.Comment: 13 pages, 7 figure
Dielectric spectra analysis: reliable parameter estimation using interval analysis
Dielectric spectroscopy is an extremely versatile method for characterizing the molecular dynamics over a large range of time scales. Unfortunately, the extraction of model parameters by data fitting is still a crucial problem which is now solved by our program S.A.D.E. S.A.D.E. is based on the algorithm S.I.V.I.A. which was proposed and implemented by Jaulin in order to solve constraint satisfaction problems. The problem of dielectric data analysis is reduced to a problem of choosing the appropriate physical model. In this article, Debye relaxations were used and validated to fit the relaxations of a DGEBA prepolymer and the polarization of the spectrometer electrodes. The conductivity was evaluated too
On micro-structural effects in dielectric mixtures
The paper presents numerical simulations performed on dielectric properties
of two-dimensional binary composites on eleven regular space filling
tessellations. First, significant contributions of different parameters, which
play an important role in the electrical properties of the composite, are
introduced both for designing and analyzing material mixtures. Later, influence
of structural differences and intrinsic electrical properties of constituents
on the composite's over all electrical properties are investigated. The
structural differences are resolved by the spectral density representation
approach. The numerical technique, without any {\em a-priori} assumptions, for
extracting the spectral density function is also presented.Comment: 24 pages, 8 figure and 7 tables. It is submitted to IEEE Transactions
on Dielectrics and Electrical Insulatio
Dose-response associations of cardiorespiratory fitness with all-cause mortality and incidence and mortality of cancer and cardiovascular and respiratory diseases: the UK Biobank cohort study
Objective:
To investigate the association of cardiorespiratory fitness with all-cause mortality, and cardiovascular, respiratory, COPD and cancer mortality and incidence.
Design:
Prospective population based study.
Setting:
UK Biobank.
Participants:
Of the 502,628 (5.5% response rate) participants recruited by UK Biobank, we included 73,259 (14.6%) participants with available data in this analysis. Of these, 1,374 participants died and 4,210 developed circulatory diseases, 1,293 respiratory diseases and 4,281 cancer, over a median of 5.0 years [IQR 4.3–5.7] follow-up.
Main outcome measures - All-cause mortality and circulatory disease, respiratory disease, chronic obstructive e pulmonary disease (COPD) and cancer (any-type, colorectal, lung, breast and prostate) mortality/incidence. Fitness was estimated with a submaximal cycle ergometer test.
Results:
The hazard ratio for all-cause mortality for each MET higher fitness was 0.96 ([95% CI 0.93–0.98]). Similar results were observed for incident circulatory (HR 0.96 [0.95–0.97]), respiratory disease (HR 0.96 [0.94–0.98]), COPD (HR 0.90 [0.86–0.95]), and colorectal cancer (HR 0.96 [0.92–1.00]). Nonlinear analysis revealed that a high level of fitness (>10 METs) was associated with a greater incidence of atrial fibrillation (HR 1.24 [1.07–1.44]) and prostate cancer (HR 1.16 [1.02–1.32]) compared with average fitness. All results were adjusted for sociodemographic, lifestyle, and dietary factors, body composition, and morbidity at baseline and excluded events in the first 2 years of follow up.
Conclusions:
Higher cardiorespiratory fitness was associated with lower risk of premature mortality and incidence of cardiovascular, respiratory disease and colorectal cancer
Silicon carbide particulates incorporated into microalloyed steel surface using TIG: microstructure and properties
Surface metal matrix composites have been developed to enhance properties such as erosion, wear and corrosion of alloys. In this study, ~5 µm or ~75 µm SiC particulates were preplaced on a microalloyed steel. Single track surface zones were melted by a tungsten inert gas torch, and the effect of two heat inputs, 420Jmm-1 and 840 Jmm-1,compared. The results showed that the samples melted using 420Jmm-1 were crack-free. Pin-on-disk wear testing under dry sliding conditions were conducted. The effects of load and sliding velocity were used to characterise the performance of the crack-free samples. Microstructural and X-ray diffraction studies of the surface showed that the SiC had dissolved, and that martensite, was the main phase influencing the hardness
The inflammatory microenvironment in colorectal neoplasia
Peer reviewedPublisher PD
Association between adiposity levels and cognitive impairment in the Chilean older adult population
Although both obesity and ageing are risk factors for cognitive impairment, there is no evidence in Chile on how obesity levels are associated with cognitive function. Therefore, the aim of the present study was to investigate the association between adiposity levels and cognitive impairment in older Chilean adults. This cross-sectional study includes 1384 participants, over 60 years of age, from the Chilean National Health Survey 2009–2010. Cognitive impairment was evaluated using the Mini-Mental State Examination. BMI and waist circumference (WC) were used as measures of adiposity. Compared with people with a normal BMI, the odds of cognitive impairment were higher in participants who were underweight (OR 4·44; 95 % CI 2·43, 6·45; P < 0·0001), overweight (OR 1·86; 95 % CI 1·06, 2·66; P = 0·031) and obese (OR 2·26; 95 % CI 1·31, 3·21; P = 0·003). The associations were robust after adjustment for confounding variables. Similar results were observed for WC. Low and high levels of adiposity are associated with an increased likelihood of cognitive impairment in older adults in Chile
Ionic liquid based EDLCs: influence of carbon porosity on electrochemical performance
Electrochemical double layer capacitors (EDLCs) are a category of supercapacitors; devices that store charge at the interface between electrodes and an electrolyte. Currently available commercial devices have a limited operating potential that restricts their energy and power densities. Ionic liquids (ILs) are a promising alternative electrolyte as they generally exhibit greater electrochemical stabilities and lower volatility. This work investigates the electrochemical performance of EDLCs using ILs that combine the bis(trifluoromethanesulfonyl)imide anion with sulfonium and ammonium based cations. Different activated carbon materials were employed to also investigate the influence of varying pore size on electrochemical performance. Electrochemical impedance spectroscopy (EIS) and constant current cycling at different rates were used to assess resistance and specific capacitance. In general, greater specific capacitances and lower resistances were found with the sulfonium based ILs studied, and this was attributed to their smaller cation volume. Comparing electrochemical stabilities indicated that significantly higher operating potentials are possible with the ammonium based ILs. The marginally smaller sulfonium cation performed better with the carbon exhibiting the largest pore width, whereas peak performance of the larger sulfonium cation was associated with a narrower pore size. Considerable differences between the performance of the ammonium based ILs were observed and attributed to differences not only in cation size but also due to the inclusion of a methoxyethyl group. The improved performance of the ether bond containing IL was ascribed to electron donation from the oxygen atom influencing the charge density of the cation and facilitating cation–cation interactions
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