Local Voids as the Origin of Large-angle Cosmic Microwave Background Anomalies: The Effect of a Cosmological Constant

We explore the large angular scale temperature anisotropies in the cosmic microwave background (CMB) due to homogeneous local dust-filled voids in a flat Friedmann-Robertson-Walker universe with a cosmological constant. In comparison with the equivalent dust-filled void model in the Einstein-de Sitter background, we find that the anisotropy for compensated asymptotically expanding local voids can be larger because second-order effects enhance the linear integrated Sachs-Wolfe (ISW) effect. However, for local voids that expand sufficiently faster than the asymptotic velocity of the wall, the second-order effect can suppress the fluctuation due to the linear ISW effect. A pair of quasi-linear compensated asymptotic local voids with radius (2-3)*10^2 ~h^{-1} Mpc and a matter density contrast ~-0.3 can be observed as cold spots with a temperature anisotropy Delta T/T~O(10^{-5}) that might help explain the observed large-angle CMB anomalies. We predict that the associated anisotropy in the local Hubble constant in the direction of the voids could be as large as a few percent.Comment: 23 pages, 5 figures, version accepted for publication in ApJ with minor revisio

Delayed Recombination and Standard Rulers

Measurements of Baryonic Acoustic Oscillations in galaxy surveys have been recognized as a powerful tool for constraining dark energy. However, this method relies on the knowledge of the size of the acoustic horizon at recombination derived from Cosmic Microwave Background Anisotropy measurements. This estimate is typically derived assuming a standard recombination scheme; additional radiation sources can delay recombination altering the cosmic ionization history and the cosmological inferences drawn from CMB and BAO data. In this paper we quantify the effect of delayed recombination on the determination of dark energy parameters from future BAO surveys such as BOSS and WFMOS. We find the impact to be small but still not negligible. In particular, if recombination is non-standard (to a level still allowed by CMB data), but this is ignored, future surveys may incorrectly suggest the presence of a redshift dependent dark energy component. On the other hand, in the case of delayed recombination, adding to the analysis one extra parameter describing deviations from standard recombination, does not significantly degrade the error-bars on dark energy parameters and yields unbiased estimates.Comment: 8 pages, 5 figure

Relativistic jet feedback - III. Feedback on gas discs

We study the interactions of a relativistic jet with a dense turbulent gaseous disc of radius ~2 kpc. We have performed a suite of simulations with different mean density, jet power, and orientation. Our results show that: (A) The relativistic jet couples strongly with the gas in the inner kpc, creating a cavity and launching outflows. (B) The high pressure bubble inflated by the jet and its back-flow compresses the disc at the outer edges, driving inflows within the disc. (C) Jets inclined towards the disc affect the disc more and launch sub-relativistic, wide-angled outflows along the minor axis. (D) Shocks driven directly by the jet and the jet-driven energy bubble raise the velocity dispersion throughout the disc by several times its initial value. (E) Compression by the jet-driven shocks can enhance the star formation rate in the disc, especially in a ring-like geometry close to the axis. However, enhanced turbulent dispersion in the disc also leads to quenching of star formation. Whether positive or negative feedback dominates depends on jet power, ISM density, jet orientation with respect to the disc, and the time-scale under consideration. Qualitatively, our simulations compare favourably with kinematic and morphological signatures of several observed galaxies such as NGC 1052, NGC 3079, 3C 326, and 3C 293.DM’s visit to JHU was supported by a Balzan grant from New College, Oxford. AYW has been supported in part by ERC Project No. 267117 (DARK) hosted by Universite Pierre ´ et Marie Curie (UPMC) – Paris 6, PI: J. Silk

Cosmic Star Formation, Reionization, and Constraints on Global Chemical Evolution

Motivated by the WMAP results indicating an early epoch of reionization, we consider alternative cosmic star formation models which are capable of reionizing the early intergalactic medium. We develop models which include an early burst of massive stars (with several possible mass ranges) combined with standard star formation. We compute the stellar ionizing flux of photons and we track the nucleosynthetic yields for several elements: D, He4, C, N, O, Si, S, Fe, Zn. We compute the subsequent chemical evolution as a function of redshift, both in the intergalactic medium and in the interstellar medium of forming galaxies, starting with the primordial objects which are responsible for the reionization. We apply constraints from the observed abundances in the Lyman alpha forest and in Damped Lyman alpha clouds in conjunction with the ability of the models to produce the required degree of reionization. We also consider possible constraints associated with the observations of the two extremely metal-poor stars HE 0107-5240 and CS22949-037. We confirm that an early top-heavy stellar component is required, as a standard star formation model is unable to reionize the early Universe and reproduce the abundances of the very metal-poor halo stars. A bimodal (or top-heavy) IMF (40 - 100 M_\odot) is our preferred scenario compared to the extreme mass range (\ga 100 M_\odot) often assumed to be responsible for the early stages of reionization. A mode of even more extreme stellar masses in the range (\ge 270 M_\odot) has also been considered. All massive stars in this mode collapse entirely into black holes, and as a consequence, chemical evolution and reionization are de-correlated. [Abstract abbreviated.]Comment: 45 pages, 18 eps figures, as accepted in Ap

Probing the evolution of early-type cluster galaxies through chemical enrichment

A simple chemical enrichment model for cluster early-type galaxies is described in which the mechanisms considered in the evolutionary model are infall of primordial gas, outflows and a possible variation in the star formation efficiency. We find that - within the framework of our models - only outflows can generate a suitable range of metallicities. The chemical enrichment tracks can be combined with the latest population synthesis models to simulate clusters over a wide redshift range, for a set of toy models. The color-magnitude relation of local clusters is used as a constraint, fixing the correlation between absolute luminosity and ejected fraction of gas from outflows. It is found that the correlations between color or mass-to-light ratios and absolute luminosity are degenerate with respect to most of the input parameters. However, a significant change between monolithic and hierarchical models is predicted for redshifts z\simgt 1. The comparison between predicted and observed mass-to-light ratios yield an approximate linear bias between total and stellar masses: $M_{\rm Tot}\propto M_{\rm St}^{1.15\pm 0.08}$ in early-type galaxies. If we assume that outflows constitute the driving mechanism for the colors observed in cluster early type galaxies, the metallicity of the intracluster medium (ICM) can be linked to outflows. The color-magnitude constraint requires faint $M_V\sim -16$ galaxies to eject 85% of their gas, which means that most of the metals in the ICM may have originated in these dwarf galaxies.Comment: Accepted for publication in ApJ. Uses emulateapj.sty. 12 pages with 10 embedded EPS figure

Cumulants as non-Gaussian qualifiers

We discuss the requirements of good statistics for quantifying non-Gaussianity in the Cosmic Microwave Background. The importance of rotational invariance and statistical independence is stressed, but we show that these are sometimes incompatible. It is shown that the first of these requirements prefers a real space (or wavelet) formulation, whereas the latter favours quantities defined in Fourier space. Bearing this in mind we decide to be eclectic and define two new sets of statistics to quantify the level of non-Gaussianity. Both sets make use of the concept of cumulants of a distribution. However, one set is defined in real space, with reference to the wavelet transform, whereas the other is defined in Fourier space. We derive a series of properties concerning these statistics for a Gaussian random field and show how one can relate these quantities to the higher order moments of temperature maps. Although our frameworks lead to an infinite hierarchy of quantities we show how cosmic variance and experimental constraints give a natural truncation of this hierarchy. We then focus on the real space statistics and analyse the non-Gaussian signal generated by points sources obscured by large scale Gaussian fluctuations. We conclude by discussing the practical implementations of these techniques

Star formation in 30 Doradus

Using observations obtained with the Wide Field Camera 3 (WFC3) on board the Hubble Space Telescope (HST), we have studied the properties of the stellar populations in the central regions of 30 Dor, in the Large Magellanic Cloud. The observations clearly reveal the presence of considerable differential extinction across the field. We characterise and quantify this effect using young massive main sequence stars to derive a statistical reddening correction for most objects in the field. We then search for pre-main sequence (PMS) stars by looking for objects with a strong (> 4 sigma) Halpha excess emission and find about 1150 of them over the entire field. Comparison of their location in the Hertzsprung-Russell diagram with theoretical PMS evolutionary tracks for the appropriate metallicity reveals that about one third of these objects are younger than ~4Myr, compatible with the age of the massive stars in the central ionising cluster R136, whereas the rest have ages up to ~30Myr, with a median age of ~12Myr. This indicates that star formation has proceeded over an extended period of time, although we cannot discriminate between an extended episode and a series of short and frequent bursts that are not resolved in time. While the younger PMS population preferentially occupies the central regions of the cluster, older PMS objects are more uniformly distributed across the field and are remarkably few at the very centre of the cluster. We attribute this latter effect to photoevaporation of the older circumstellar discs caused by the massive ionising members of R136.Comment: 15 pages, 12 figures. Accepted for publication in The Astrophysical Journa

Therapy with high-dose Interleukin-2 (HD IL-2) in metastatic melanoma and renal cell carcinoma following PD1 or PDL1 inhibition

Abstract Background Metastatic melanoma (mM) and renal cell carcinoma (mRCC) are often treated with anti-PD-1 based therapy, however not all patients respond and further therapies are needed. High dose interleukin-2 (HD IL-2) can lead to durable responses in a subset of mM and mRCC patients. The efficacy and toxicity of HD IL-2 therapy following anti-PD-1 or anti-PD-L1 therapy have not yet been explored. Methods Reports on mM and mRCC patients who had received HD IL-2 after PD-1 or PD-L1 inhibition were queried from the PROCLAIMSM database. Patient characteristics, toxicity and efficacy were analyzed. Results A total of 57 patients (40 mM, 17 mRCC) were treated with high dose IL-2 after PD-1 or PD-L1 inhibition and had data recorded in the PROCLAIM database. The best overall response rate to HD IL-2 was 22.5% for mM (4 complete response (CR), 5 partial responses (PRs)) and 24% for mRCC (2 CRs, 2 PRs). The toxicity related to HD IL-2 observed in these patients was similar to that observed in patients treated with HD IL-2 without prior checkpoint blockade. One patient who had received prior PD-L1 blockade developed drug induced pneumonitis with HD IL-2 requiring steroid therapy. Conclusion In this retrospective analysis, HD IL-2 therapy displayed durable antitumor activity in mM and mRCC patients who progressed following treatment with PD-1 and PD-L1 inhibition. The toxicities were generally manageable and consistent with expectations from HD IL-2 but physicians should watch for immune related toxicities such as pneumonitis. This analysis supports the development of randomized prospective trials to assess the proper sequencing and combination of immune checkpoint blockade and cytokine therapy.https://deepblue.lib.umich.edu/bitstream/2027.42/148134/1/40425_2019_Article_522.pd

Using H-alpha Morphology and Surface Brightness Fluctuations to Age-Date Star Clusters in M83

We use new WFC3 observations of the nearby grand design spiral galaxy M83 to develop two independent methods for estimating the ages of young star clusters. The first method uses the physical extent and morphology of Halpha emission to estimate the ages of clusters younger than tau ~10 Myr. It is based on the simple premise that the gas in very young (tau < few Myr) clusters is largely coincident with the cluster stars, is in a small, ring-like structure surrounding the stars in slightly older clusters (e.g., tau ~5 Myr), and is in a larger ring-like bubble for still older clusters (i.e., ~5-10 Myr). The second method is based on an observed relation between pixel-to-pixel flux variations within clusters and their ages. This method relies on the fact that the brightest individual stars in a cluster are most prominent at ages around 10 Myr, and fall below the detection limit (i.e., M_V < -3.5) for ages older than about 100 Myr. These two methods are the basis for a new morphological classification system which can be used to estimate the ages of star clusters based on their appearance. We compare previous age estimates of clusters in M83 determined from fitting UBVI Halpha measurements using predictions from stellar evolutionary models with our new morphological categories and find good agreement at the ~95% level. The scatter within categories is ~0.1 dex in log tau for young clusters (10 Myr) clusters. A by-product of this study is the identification of 22 "single-star" HII regions in M83, with central stars having ages ~4 Myr.Comment: 33 pages, 10 figures, 3 tables; published in March Ap

The HST Survey of BL Lacertae Objects. II. Host Galaxies

We have used the HST WFPC2 camera to survey 132 BL Lac objects comprising seven complete radio-, X-ray-, and optically-selected samples. We obtained useful images for 110 targets spanning the redshift range 0 < z < 1.3. In two thirds of the BL Lac images, host galaxies are detected, including nearly all for z < 0.5 (58 of 63). The highest redshift host galaxy detected is in a BL Lac object at z=0.664. In 58 of the 72 resolved host galaxies, a de Vaucouleurs profile is significantly preferred, at >99% confidence, over a pure exponential disk; the two fits are comparable in the remaining 14 cases. These results limit the number of disk systems to at most 8% of BL Lacs (at 99% confidence), and are consistent with all BL~Lac host galaxies being ellipticals. The detected host galaxies are luminous ellipticals with a median absolute K-corrected magnitude of M_R= -23.7 +- 0.6 mag, at least one magnitude brighter than M* and comparable to brightest cluster galaxies. The galaxy morphologies are generally smooth and undisturbed, with small or negligible ellipticities (<0.2). There is no correlation between host galaxy and observed nuclear magnitude or estimated jet power corrected for beaming. If black hole mass is correlated linearly with bulge mass in general, this implies a large range in Eddington ratio. Present data strongly support the unification picture with FR I galaxies constituting the bulk of the parent population of BL Lac objects.Comment: Accepted for publication on ApJ. 38 pages, 8 figure