68 research outputs found
The role of dendritic cells in the immunopathogenesis of psoriasis
Psoriasis vulgaris is a chronic inflammatory skin disease that is marked by a complex interplay of dendritic cells (DCs), T-cells, cytokines, and downstream transcription factors as part of a self-sustaining type 1 cytokine network. As integral players of the immune system, DCs represent antigen-presenting cells that are crucial for efficient activation of T-cells and B-cells. DCs have also been linked to distinct chronic inflammatory conditions, including psoriasis. In the setting of psoriasis therapy, DC/T cell interactions serve as a potential target for biologic response modifiers. Here we describe the major DC subsets as well as the immunologic involvement of DCs within the context of psoriatic lesions
Ultrastructural and phenotypic changes in Langerhans cells induced in vitro by contact allergens
Alterations of Clinically Normal Skin in Early Eruptive Guttate Psoriasis. A Light- and Electron-Microscopic Study
Indomethacin inhibits the chemical carcinogen benzo(a)pyrene but not dimethylbenz(a)anthracene from altering Langerhans cell distribution and morphology
Dynamic changes in epidermal Ia-positive cells in allergic contact sensitivity reactions in mice
Keratinocytes Function as Accessory Cells for Presentation of Endogenous Antigen Expressed in the Epidermis
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