2,946 research outputs found
Bostonia Magazine. Volume 56
Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs
Simultaneous IUE, EXOSAT and optical observations of the unusual AM Her type variable H058+608
Simultaneous observations of the AM Her type variable H0538+608 made with IUE, EXOSAT, and a 1.3 m ground based telescope, and subsequent optical spectrophotometry at high and low resolution are discussed. The X-ray and optical data show clear evidence of a 3.30 + or - 0.03 hr period. Three SWP spectra were taken outside of eclipse and during overlapping phase intervals. The UV spectra contain strong emission lines characteristic of this class of objects and a flat continuum which appears to be deficient, given the brightness of source at optical and X-ray wavelengths. There is evidence for intensity variations in emission lines, particularly C IV. The X-ray light curves for H0538+608 reveal behavior which may be related to irregularities in its accretion flow
Study protocol: Delayed intervention randomised controlled trial within the Medical Research Council (MRC) Framework to assess the effectiveness of a new palliative care service
Background: Palliative care has been proposed to help meet the needs of patients who suffer
progressive non-cancer conditions but there have been few evaluations of service development
initiatives. We report here a novel protocol for the evaluation of a new palliative care service in
this context.
Methods/Design: Using the MRC Framework for the Evaluation of Complex Interventions we
modelled a new palliative care and neurology service for patients severely affected by Multiple
Sclerosis (MS). We conducted qualitative interviews with patients, families and staff, plus a
literature review to model and pilot the service. Then we designed a delayed intervention
randomised controlled trial to test its effectiveness as part of phase II of the MRC framework.
Inclusion criteria for the trial were patients identified by referring clinicians as having unresolved
symptoms or psychological concerns. Referrers were advised to use a score of greater than 8 on
the Expanded Disability Scale was a benchmark. Consenting patients newly referred to the new
service were randomised to either receive the palliative care service immediately (fast-track) or
after a 12-week wait (standard best practice). Face to face interviews were conducted at baseline
(before intervention), and at 4–6, 10–12 (before intervention for the standard-practice group), 16–
18 and 22–24 weeks with patients and their carers using standard questionnaires to assess
symptoms, palliative care outcomes, function, service use and open comments. Ethics committee
approval was granted separately for the qualitative phase and then for the trial.
Discussion: We publish the protocol trial here, to allow methods to be reviewed in advance of
publication of the results. The MRC Framework for the Evaluation of Complex Interventions was
helpful in both the design of the service, methods for evaluation in convincing staff and the ethics
committee to accept the trial. The research will provide valuable information on the effects of
palliative care among non-cancer patients and a method to evaluate palliative care in this context
Stabilizing unstable periodic orbits in the Lorenz equations using time-delayed feedback control
For many years it was believed that an unstable periodic orbit with an odd
number of real Floquet multipliers greater than unity cannot be stabilized by
the time-delayed feedback control mechanism of Pyragus. A recent paper by
Fiedler et al uses the normal form of a subcritical Hopf bifurcation to give a
counterexample to this theorem. Using the Lorenz equations as an example, we
demonstrate that the stabilization mechanism identified by Fiedler et al for
the Hopf normal form can also apply to unstable periodic orbits created by
subcritical Hopf bifurcations in higher-dimensional dynamical systems. Our
analysis focuses on a particular codimension-two bifurcation that captures the
stabilization mechanism in the Hopf normal form example, and we show that the
same codimension-two bifurcation is present in the Lorenz equations with
appropriately chosen Pyragus-type time-delayed feedback. This example suggests
a possible strategy for choosing the feedback gain matrix in Pyragus control of
unstable periodic orbits that arise from a subcritical Hopf bifurcation of a
stable equilibrium. In particular, our choice of feedback gain matrix is
informed by the Fiedler et al example, and it works over a broad range of
parameters, despite the fact that a center-manifold reduction of the
higher-dimensional problem does not lead to their model problem.Comment: 21 pages, 8 figures, to appear in PR
Application of magnetically induced hyperthermia on the model protozoan Crithidia fasciculata as a potential therapy against parasitic infections
Magnetic hyperthermia is currently an EU-approved clinical therapy against
tumor cells that uses magnetic nanoparticles under a time varying magnetic
field (TVMF). The same basic principle seems promising against trypanosomatids
causing Chagas disease and sleeping sickness, since therapeutic drugs available
display severe side effects and drug-resistant strains. However, no
applications of this strategy against protozoan-induced diseases have been
reported so far. In the present study, Crithidia fasciculata, a widely used
model for therapeutic strategies against pathogenic trypanosomatids, was
targeted with Fe_{3}O_{4} magnetic nanoparticles (MNPs) in order to remotely
provoke cell death using TVMFs. The MNPs with average sizes of d approx. 30 nm
were synthesized using a precipitation of FeSO_{4}4 in basic medium. The MNPs
were added to Crithidia fasciculata choanomastigotes in exponential phase and
incubated overnight. The amount of uploaded MNPs per cell was determined by
magnetic measurements. Cell viability using the MTT colorimetric assay and flow
cytometry showed that the MNPs were incorporated by the cells with no
noticeable cell-toxicity effects. When a TVMF (f = 249 kHz, H = 13 kA/m) was
applied to MNP-bearing cells, massive cell death was induced via a
non-apoptotic mechanism. No effects were observed by applying a TVMF on control
(without loaded MNPs) cells. No macroscopic rise in temperature was observed in
the extracellular medium during the experiments. Scanning Electron Microscopy
showed morphological changes after TVMF experiments. These data indicate (as a
proof of principle) that intracellular hyperthermia is a suitable technology to
induce the specific death of protozoan parasites bearing MNPs. These findings
expand the possibilities for new therapeutic strategies that combat parasitic
infections.Comment: 9 pages, four supplementary video file
The Political Consequences of Racialized Ethnic Identities
Racial classifications are a social construct with no basis in biology; yet, race is an omnipresent and powerful factor in U.S. politics, shaping electoral boundaries, disbursement of resources, and political alliances (Omi and Winant 1994, Haney López 1994). Race, then, is a malleable construct wielded by varying interests, with racial definitions changing in response to social and political battles. Some new immigrant groups initially classified as not white have been reclassified as white over time, thereby benefitting from associated legal, economic, and sociopolitical privileges. More recently, however, some Latinos have sought recognition as a distinct non-white racial group, in acknowledgment of the racialization of their identities over time. We seek to better understand who is most likely to support a racialized Latino identity, and the political consequences of this choice. Using data from the 2020 Collaborative Multiracial Post-election Survey, we test whether individuals who believe that a Latino identity is a racial identity are also more likely to be interested in and engaged in politics. We also examine the extent to which support for a racialized Latino identity is associated with progressive attitudes on racial issues. © The Author(s) 2023
Contrasting Evidence Within and Between Institutions that Provide Treatment in an Observational Study of Alternate Forms of Anesthesia
In a randomized trial, subjects are assigned to treatment or control by the flip of a fair coin. In many nonrandomized or observational studies, subjects find their way to treatment or control in two steps, either or both of which may lead to biased comparisons. By a vague process, perhaps affected by proximity or sociodemographic issues, subjects find their way to institutions that provide treatment. Once at such an institution, a second process, perhaps thoughtful and deliberate, assigns individuals to treatment or control. In the current article, the institutions are hospitals, and the treatment under study is the use of general anesthesia alone versus some use of regional anesthesia during surgery. For a specific operation, the use of regional anesthesia may be typical in one hospital and atypical in another. A new matched design is proposed for studies of this sort, one that creates two types of nonoverlapping matched pairs. Using a new extension of optimal matching with fine balance, pairs of the first type exactly balance treatment assignment across institutions, so each institution appears in the treated group with the same frequency that it appears in the control group; hence, differences between institutions that affect everyone in the same way cannot bias this comparison. Pairs of the second type compare institutions that assign most subjects to treatment and other institutions that assign most subjects to control, so each institution is represented in the treated group if it typically assigns subjects to treatment or, alternatively, in the control group if it typically assigns subjects to control, and no institution appears in both groups. By and large, in the second type of matched pair, subjects became treated subjects or controls by choosing an institution, not by a thoughtful and deliberate process of selecting subjects for treatment within institutions. The design provides two evidence factors, that is, two tests of the null hypothesis of no treatment effect that are independent when the null hypothesis is true, where each factor is largely unaffected by certain unmeasured biases that could readily invalidate the other factor. The two factors permit separate and combined sensitivity analyses, where the magnitude of bias affecting the two factors may differ. The case of knee surgery in the study of regional versus general anesthesia is considered in detail
Super-lattice, rhombus, square, and hexagonal standing waves in magnetically driven ferrofluid surface
Standing wave patterns that arise on the surface of ferrofluids by (single
frequency) parametric forcing with an ac magnetic field are investigated
experimentally. Depending on the frequency and amplitude of the forcing, the
system exhibits various patterns including a superlattice and subharmonic
rhombuses as well as conventional harmonic hexagons and subharmonic squares.
The superlattice arises in a bicritical situation where harmonic and
subharmonic modes collide. The rhombic pattern arises due to the non-monotonic
dispersion relation of a ferrofluid
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