High-Dimensional Dependency Structure Learning for Physical Processes

In this paper, we consider the use of structure learning methods for probabilistic graphical models to identify statistical dependencies in high-dimensional physical processes. Such processes are often synthetically characterized using PDEs (partial differential equations) and are observed in a variety of natural phenomena, including geoscience data capturing atmospheric and hydrological phenomena. Classical structure learning approaches such as the PC algorithm and variants are challenging to apply due to their high computational and sample requirements. Modern approaches, often based on sparse regression and variants, do come with finite sample guarantees, but are usually highly sensitive to the choice of hyper-parameters, e.g., parameter $\lambda$ for sparsity inducing constraint or regularization. In this paper, we present ACLIME-ADMM, an efficient two-step algorithm for adaptive structure learning, which estimates an edge specific parameter $\lambda_{ij}$ in the first step, and uses these parameters to learn the structure in the second step. Both steps of our algorithm use (inexact) ADMM to solve suitable linear programs, and all iterations can be done in closed form in an efficient block parallel manner. We compare ACLIME-ADMM with baselines on both synthetic data simulated by partial differential equations (PDEs) that model advection-diffusion processes, and real data (50 years) of daily global geopotential heights to study information flow in the atmosphere. ACLIME-ADMM is shown to be efficient, stable, and competitive, usually better than the baselines especially on difficult problems. On real data, ACLIME-ADMM recovers the underlying structure of global atmospheric circulation, including switches in wind directions at the equator and tropics entirely from the data.Comment: 21 pages, 8 figures, International Conference on Data Mining 201

Postpartum hemorrhage as a result of acquired uterine arteriovenous fistula post-vaginal delivery

Objective: A 24-year-old woman with secondary postpartum hemorrhages stemming from a Acquired uterine arteriovenous fistula (UAVF) induced after spontaneous vaginal delivery without a history of artificial removal of the placenta during childbirth. The initial diagnosis using conventional ultrasonography resulted in the suspicion of a UAVF, digital subtraction arteriography confirmed the lesion of typical UAVF. Hysteroscopy detected a false passage in the uterus. An acquired UAVF generally results from trauma, which can often be confused with retained products of conception. Results: Pelvic DSA was promptly performed, proving the earlier suspicion of the lesion of typical UAVF over the left uterine artery. UAE of the bilateral uterine arteries was immediately carried out with microspheres for embolization, occluding active bleeders. Conclusions: UAVF, induced after spontaneous vaginal delivery without artificial removal of the placenta, is a rare cause of postpartum vaginal bleeding. Timely diagnosis is of utmost importance. The few published case series and single case report of UAVF may represent the tip of the iceberg. By sharing this case report, we hope our experience will add to obstetricians and gynecologists an increasing awareness that UAVFs may be more common than previously thought and more attention to UAVF in clinical work, so patients can undergone appropriate diagnostic and treatment

The diagnostic performance of machine learning based on resting-state functional magnetic resonance imaging data for major depressive disorders: a systematic review and meta-analysis

ObjectiveMachine learning (ML) has been widely used to detect and evaluate major depressive disorder (MDD) using neuroimaging data, i.e., resting-state functional magnetic resonance imaging (rs-fMRI). However, the diagnostic efficiency is unknown. The aim of the study is to conduct an updated meta-analysis to evaluate the diagnostic performance of ML based on rs-fMRI data for MDD.MethodsEnglish databases were searched for relevant studies. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used to assess the methodological quality of the included studies. A random-effects meta-analytic model was implemented to investigate the diagnostic efficiency, including sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC). Regression meta-analysis and subgroup analysis were performed to investigate the cause of heterogeneity.ResultsThirty-one studies were included in this meta-analysis. The pooled sensitivity, specificity, DOR, and AUC with 95% confidence intervals were 0.80 (0.75, 0.83), 0.83 (0.74, 0.82), 14.00 (9, 22.00), and 0.86 (0.83, 0.89), respectively. Substantial heterogeneity was observed among the studies included. The meta-regression showed that the leave-one-out cross-validation (loocv) (sensitivity: p < 0.01, specificity: p < 0.001), graph theory (sensitivity: p < 0.05, specificity: p < 0.01), n > 100 (sensitivity: p < 0.001, specificity: p < 0.001), simens equipment (sensitivity: p < 0.01, specificity: p < 0.001), 3.0T field strength (Sensitivity: p < 0.001, specificity: p = 0.04), and Beck Depression Inventory (BDI) (sensitivity: p = 0.04, specificity: p = 0.06) might be the sources of heterogeneity. Furthermore, the subgroup analysis showed that the sample size (n > 100: sensitivity: 0.71, specificity: 0.72, n < 100: sensitivity: 0.81, specificity: 0.79), the different levels of disease evaluated by the Hamilton Depression Rating Scale (HDRS/HAMD) (mild vs. moderate vs. severe: sensitivity: 0.52 vs. 0.86 vs. 0.89, specificity: 0.62 vs. 0.78 vs. 0.82, respectively), the depression scales in patients with comparable levels of severity. (BDI vs. HDRS/HAMD: sensitivity: 0.86 vs. 0.87, specificity: 0.78 vs. 0.80, respectively), and the features (graph vs. functional connectivity: sensitivity: 0.84 vs. 0.86, specificity: 0.76 vs. 0.78, respectively) selected might be the causes of heterogeneity.ConclusionML showed high accuracy for the automatic diagnosis of MDD. Future studies are warranted to promote the potential use of these classification algorithms in clinical settings

Differential expression of cyclins CCNB1 and CCNG1 is involved in the chondrocyte damage of kashin-beck disease

The purpose of this study was clarify the relationship between the differential expression of cyclins CCNB1 and CCNG1 and chondrocyte damage in Kashin-Beck disease. Systematic review and high-throughput sequencing of chondrocytes derived from Kashin-Beck disease patients were combined to identify the differentially expressed cyclins and cyclin-dependent kinase genes. In parallel, weaned SD rats were treated with low selenium for 4 weeks and then T-2 toxin for 4 weeks. Knee cartilage was collected to harvest chondrocytes for gene expression profiling. Finally, the protein expression levels of CCNB1 and CCNG1 were verified in knee cartilage tissue of Kashin-Beck disease patients and normal controls by immunohistochemical staining. The systematic review found 52 cartilage disease-related cyclins and cyclin-dependent kinase genes, 23 of which were coexpressed in Kashin-Beck disease, including 15 upregulated and 8 downregulated genes. Under the intervention of a low selenium diet and T-2 toxin exposure, CCNB1 (FC = 0.36) and CCNG1 (FC = 0.73) showed a downward expression trend in rat articular cartilage. Furthermore, compared to normal controls, CCNB1 protein in Kashin-Beck disease articular cartilage was 71.98% and 66.27% downregulated in the superficial and middle zones, respectively, and 12.06% upregulated in the deep zone. CCNG1 protein was 45.66% downregulated in the superficial zone and 12.19% and 9.13% upregulated in the middle and deep zones, respectively. The differential expression of cyclins CCNB1 and CCNG1 may be related to articular cartilage damage in Kashin-Beck disease

Aggregation-Induced Emission (AIE), Life and Health

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health

Newly formed dust within the circumstellar environment of SN Ia-CSM 2018evt

Dust associated with various stellar sources in galaxies at all cosmic epochs remains a controversial topic, particularly whether supernovae play an important role in dust production. We report evidence of dust formation in the cold, dense shell behind the ejecta–circumstellar medium (CSM) interaction in the Type Ia-CSM supernova (SN) 2018evt three years after the explosion, characterized by a rise in mid-infrared emission accompanied by an accelerated decline in the optical radiation of the SN. Such a dust-formation picture is also corroborated by the concurrent evolution of the profiles of the Hα emission line. Our model suggests enhanced CSM dust concentration at increasing distances from the SN as compared to what can be expected from the density profile of the mass loss from a steady stellar wind. By the time of the last mid-infrared observations at day +1,041, a total amount of 1.2 ± 0.2 × 10−2 M⊙ of new dust has been formed by SN 2018evt, making SN 2018evt one of the most prolific dust factories among supernovae with evidence of dust formation. The unprecedented witness of the intense production procedure of dust may shed light on the perceptions of dust formation in cosmic history

Female early-career scientists have conducted less interdisciplinary research in the past six decades: evidence from doctoral theses

Abstract Interdisciplinary research is a driving force of transformative and innovative science, yet it remains unclear how early-career scientists pursue interdisciplinary research paths. Analyzing data from 675,135 doctoral theses of U.S. Ph.D. graduates who graduated from 1950 to 2016, we study the development of interdisciplinary doctoral theses in the five scientific domains of behavioral sciences, biological sciences, engineering, health and medical sciences, and mathematical and physical sciences. We propose an indicator to measure the degree of interdisciplinarity embedded in the doctoral research by employing co-occurrence matrices of subjects assigned to doctoral theses in the ProQuest Dissertations & Theses Database. This study finds that interdisciplinary doctoral theses have exhibited a growing trend across different scientific domains, and universities of varying research intensity. Since the 1990s, interdisciplinary research has played a dominant role in doctoral theses within the five scientific domains. The results of multivariate regression models suggest persistent gender disparities in the interdisciplinarity level of doctoral theses. Specifically, male-authored doctoral theses demonstrate a higher level of interdisciplinarity than female-authored doctoral theses. In addition, this study suggests that being supervised by female advisors may amplify gender disparities in the interdisciplinarity level of their students’ doctoral theses. The findings indicate the potential underrepresentation of female scientists in pursuing interdisciplinary research at the early stages of their careers. Given that funding agencies have promoted interdisciplinary research and its potential benefits, the lower level of interdisciplinarity in the doctoral theses of female students may hinder their career advancement. Furthermore, our findings indicate that offering increased support to female faculty members may not only directly benefit their career development but also hold considerable significance in promoting future generations of female scientists. The findings of this study have important policy implications for advancing the careers of female scientists

Resource Allocation and 3D Deployment of UAVs-Assisted MEC Network with Air-Ground Cooperation

Equipping an unmanned aerial vehicle (UAV) with a mobile edge computing (MEC) server is an interesting technique for assisting terminal devices (TDs) to complete their delay sensitive computing tasks. In this paper, we investigate a UAV-assisted MEC network with air–ground cooperation, where both UAV and ground access point (GAP) have a direct link with TDs and undertake computing tasks cooperatively. We set out to minimize the maximum delay among TDs by optimizing the resource allocation of the system and by three-dimensional (3D) deployment of UAVs. Specifically, we propose an iterative algorithm by jointly optimizing UAV–TD association, UAV horizontal location, UAV vertical location, bandwidth allocation, and task split ratio. However, the overall optimization problem will be a mixed-integer nonlinear programming (MINLP) problem, which is hard to deal with. Thus, we adopt successive convex approximation (SCA) and block coordinate descent (BCD) methods to obtain a solution. The simulation results have shown that our proposed algorithm is efficient and has a great performance compared to other benchmark schemes