THE PRAYER OF JACOB CHAPTER 1

The primary source that will be used in this translation is The prayer of Jacob chapter 1. The selected text is from Henrichs and Preisendanz 1974:148–149. I will also make reference to the translation of the text in Charlesworth’s Old Testament Greek pseudepigrapha with morphology (1983).1 According to Penner and Heiser (2008), the term pseudepigrapha does not mean ‘false books’ or ‘false writings’, but rather refers to writings that were not written by those whose names appear in them (falsely attributed writings). The Old Testament pseudepigrapha builds on the narratives, themes, and worldview of the canonical books of the Old Testament. This explains why books may be attributed to significant Old Testament figures. This source was selected because it demonstrates dramatically the enduring influence of the Old Testament on Jewish thinking after the exile

Chinese Women\u27s Experience Of Transition Towards Married State: A Multistate/multivariate Analysis Of China In-depth Fertility Survey Data, 1985

In the context of the growing amount of socio-demographic literature on marriage, this thesis explores a theoretical synthesis for an analysis on Chinese women\u27s experience in transition to the married state, based on the China In-Depth Fertility Survey data.;The frequently cited general theories or models of marriage are broadly categorized into mathematical models and behavioural interpretations of marriage. Of the latter, the theoretical work is conventionally divided into economic and sociological perspectives. However, there exists no theoretical consensus on marriage comparable to that achieved with regard to fertility.;The thesis examines the most familiar economic and sociological theories on marriage and puts forward an analytical framework based on some clear behavioural assumptions. It is proposed that marriage can be seen as a function of motivation to marry and probability of finding a suitable mate.;The thesis conducts a multistate/multivariate analysis. The multistate life table techniques are used to model the transition from entering marriage market to betrothal, and then to married state. The findings of differential transition probabilities to betrothed and married state by birth cohorts and by place of residence help to enhance the understanding of the change in timing of nuptiality. The multivariate models examine the interrelationship between betrothal, early marriage and a set of socio-economic control variables. The analytical results have shown significant relationships between certain socio-economic characteristics, such as place of residence, birth cohort and educational attainment, and the occurrence of events of interest, i.e. betrothal and early marriage.;In conclusion, the theoretical explanations on motivation, personal quality and mate-search effectiveness in relation to the probability of betrothal and early marriage are supported in the substantive analysis. A comprehensive understanding of Chinese women\u27s experience of transition to the married state, however, requires more in-depth analyses of better designed survey in the future

EASIX und das sinusoidale Obstruktionssyndrom nach allogener Stammzelltransplantation

Das sinusoidale Obstruktionssyndrom/die venöse okklusive Leberkrankheit (SOS/VOD) zählt zu den frühen Komplikationen endothelialen Ursprungs nach hämatopoetischer Stammzelltransplantation (HSZT). Bei schwerem Verlauf von SOS/VOD ist die Mortalität hoch. Medikamente zur Prophylaxe sind verfügbar, weshalb die Identifizierung von Risikopatienten sinnvoll ist. Der ‚Endothelial Activation and Stress Index‘, kurz EASIX, ist ein aus den Parametern Laktatdehydrogenase, Kreatinin und Thrombozytenzahl bestehender Score, mit dem endotheliale Schädigungen erfasst werden. Wir untersuchten, ob in zwei unabhängigen Kohorten von Empfängern einer allogenen HSZT (alloHSZT) der EASIX-Score am Tag der Transplantation (EASIX-d0) signifikant mit der SOS/VOD-Inzidenz, dem Gesamtüberleben (OS) und der Nicht-Rezidiv-Mortalität (NRM) zusammenhängt. EASIX-d0 wurde mit den prädiktiven Fähigkeiten des kürzlich etablierten ‚VOD Risk Calculator‘ des CIBMTR verglichen. In einer dritten Kohorte untersuchten wir den Effekt von Pravastatin und Ursodesoxycholsäure (UDCA) auf die SOS/VOD-Inzidenz und das Überleben nach alloHSZT. Die kumulative Inzidenz von SOS/VOD innerhalb von 28 Tagen nach alloHSZT betrug 9,6% in der Trainingskohorte (Berlin, 2013-2015, n = 446) und 8,4% in der Validierungskohorte (Heidelberg, 2001-2009, n = 380). EASIX-d0 war in beiden Kohorten signifikant mit der SOS/VOD-Inzidenz, dem OS und der NRM assoziiert. Im Gegensatz dazu war in beiden Kohorten keine statistisch signifikante Assoziation des VOD Risk Scores des CIBMTR mit den Endpunkten SOS/VOD Inzidenz, OS oder NRM vorhanden. In der dritten Kohorte (Heidelberg, 2010-2015, n = 359) mit Pravastatin/UDCA-Gabe war die kumulative SOS/VOD Inzidenz mit 1,7% signifikant geringer im Vergleich zu der Trainings- und Validierungskohorte. Auch das OS und die NRM waren signifikant verbessert im Vergleich zu Patienten ohne Pravastatin/UDCA-Prophylaxe. Dieser protektive Effekt war besonders bei Patienten im höchsten EASIX-d0-Quartil ausgeprägt. EASIX-d0 stellt den ersten validierten Risikoscore dar, der Risikopatienten für SOS/VOD nach alloHSZT identifiziert. Die Gabe von Statin/UDCA scheint insbesondere bei Patienten mit erhöhtem Risiko für SOS/VOD eine präventive Wirkung zu haben.Sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is an early complication of endothelial origin after hematopoietic stem cell transplantation (HSCT). Severe SOS/VOD is associated with high mortality. Preventive medications are available, therefore the identification of patients at high risk for SOS/VOD would be beneficial. The ‚Endothelial Activation and Stress Index‘ (EASIX) is a score based on the parameters lactate dehydrogenase, creatinine and thrombocyte count that captures endothelial damage. We studied if EASIX assessed on the day of HSCT (EASIX-d0) is significantly associated with SOS/VOD incidence, overall survival (OS) and non-relapse mortality (NRM) in two independent cohorts of patients receiving allogeneic HSCT (alloHSCT). EASIX-d0 was compared to the recently established ‚VOD Risk Calculator‘ by the CIBMTR. In a third cohort, we studied the effects of pravastatin and ursodeoxycholic acid (UDCA) on SOS/VOD incidence and survival after alloHSCT. The cumulative incidence of SOS/VOD within 28 days after alloHSCT was 9.6% in the training cohort (Berlin, 2013-2015, n = 446) and 8.4% in the validation cohort (Heidelberg, 2001-2009, n = 380). EASIX-d0 was significantly associated with SOS/VOD incidence, OS and NRM in both cohorts. In comparison, the VOD Risk Score by the CIBMTR was not significantly associated with the endpoints SOS/VOD incidence, OS or NRM in either cohorts. In the third cohort (Heidelberg, 2010-2015, n = 359), the cumulative SOS/VOD incidence was significantly lower at 1.7% compared to the training and validation cohort. Also, the OS and NRM was significantly improved compared to patients not receiving pravastatin/UDCA as prophylaxis. This protective effect was especially distinct in patients within the highest EASIX-d0 quartile. EASIX-d0 constitutes the first validated risk score for identifying patients at risk for SOS/VOD after alloHSCT. Statins/UDCA seem to have a prophylactic effect especially in patients at high risk for SOS/VOD

Quantification of Free Sialic Acid in Human Plasma through a Robust Quinoxalinone Derivatization and LC–MS/MS Using Isotope-labeled Standard Calibration

We report an accurate quantification of free sialic acid (SA) in human plasma using LC–MS/MS method with isotope-labeled standard calibration (ILSC) and robust derivatization. Specifically, derivatization of SA with a stable and inexpensive 3,4-diaminotoluene (DAT) provides a stable product of SA with high MS response, proving a convenient and cost-effective LC–MS/MS analysis of free SA. In addition, the use of 13C3-SA as calibration standard ensured the accuracy for the measurement. This assay used ultra high performance liquid chromatography (UHPLC) for separation of native/labeled SA and IS from matrix interference, and employed mass spectrometry in multiple reaction monitoring (MRM) mode for sensitive and selective detection. We have achieved a lower limit of quantification (LLOQ) of 20 ng/mL and a total running time of 4.2 min, which is the most sensitive and quick measurement for free SA in biomatrices

Quantification of Free Sialic Acid in Human Plasma through a Robust Quinoxalinone Derivatization and LC–MS/MS Using Isotope-labeled Standard Calibration

We report an accurate quantification of free sialic acid (SA) in human plasma using LC–MS/MS method with isotope-labeled standard calibration (ILSC) and robust derivatization. Specifically, derivatization of SA with a stable and inexpensive 3,4-diaminotoluene (DAT) provides a stable product of SA with high MS response, proving a convenient and cost-effective LC–MS/MS analysis of free SA. In addition, the use of 13C3-SA as calibration standard ensured the accuracy for the measurement. This assay used ultra high performance liquid chromatography (UHPLC) for separation of native/labeled SA and IS from matrix interference, and employed mass spectrometry in multiple reaction monitoring (MRM) mode for sensitive and selective detection. We have achieved a lower limit of quantification (LLOQ) of 20 ng/mL and a total running time of 4.2 min, which is the most sensitive and quick measurement for free SA in biomatrices

DE A BELA ADORMECIDA À MALÉVOLA: O PAPEL DA MULHER NA SOCIEDADE

Este artigo teve por objetivo analisar o papel da mulher na sociedade,através da animação A Bela Adormecida e sua releitura, o filme Malévola,discutindo a concepção de feminino exposta neles. Utilizando o método deanálise de conteúdo, realizando a transcrição e análise de algumas falas ecenas. Fez-se uma reflexão histórica, psicológica e filosófica acerca do papelfeminino. Dessa forma, foi possível verificar modificações ao longo das releiturasdo próprio conto, como forma de reescrever a sociedade e seus papéis,identificando-se assim, as mudanças do papel da mulher na sociedade

Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel

No biomarker panel is established for prediction of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD), a major complication of allogeneic stem cell transplantation (alloSCT). We compared the potential of the Endothelial Activation and Stress Index (EASIX), based on lactate dehydrogenase, creatinine, and thrombocytes, with that of the SOS/VOD CIBMTR clinical risk score to predict SOS/VOD in two independent cohorts. In a third cohort, we studied the impact of endothelium-active prophylaxis with pravastatin and ursodeoxycholic acid (UDA) on SOS/VOD risk. The cumulative incidence of SOS/VOD within 28 days after alloSCT in the training cohort (Berlin, 2013-2015, n=446) and in the validation cohort (Heidelberg, 2002-2009, n=380) was 9.6% and 8.4%, respectively. In both cohorts, EASIX assessed at the day of alloSCT (EASIX-d0) was significantly associated with SOS/VOD incidence (p<0.0001), overall survival (OS) and non-relapse mortality (NRM). In contrast, the CIBMTR score showed no statistically significant association with SOS/VOD incidence, and did not predict OS and NRM. In patients receiving pravastatin/UDA, the cumulative incidence of SOS/VOD was significantly lower at 1.7% (p<0.0001, Heidelberg, 2010-2015, n=359) than in the two cohorts not receiving pravastatin/UDA. The protective effect was most pronounced in patients with high EASIX-d0. The cumulative SOS/VOD incidence in the highest EASIX-d0 quartiles were 18.1% and 16.8% in both cohorts without endothelial prophylaxis as compared to 2.2% in patients with pravastatin/UDA prophylaxis (p<0.0001). EASIX-d0 is the first validated biomarker for defining a subpopulation of alloSCT recipients at high risk for SOS/VOD. Statin/UDA endothelial prophylaxis could constitute a prophylactic measure for patients at increased SOS/VOD risk

Global climate model occultation lightcurves tested by August 2018 ground-based stellar occultation

Pluto's atmospheric profiles (temperature and pressure) have been studied for decades from stellar occultation lightcurves. In this paper, we look at recent Pluto Global Climate Model (GCM) results (3D temperature, pressure, and density fields) from Bertrand et al. (2020) and use the results to generate model observer's plane intensity fields (OPIF) and lightcurves by using a Fourier optics scheme to model light passing through Pluto's atmosphere (Young, 2012). This approach can accommodate arbitrary atmospheric structures and 3D distributions of haze. We compared the GCM model lightcurves with the lightcurves observed during the 15-AUG-2018 Pluto stellar occultation. We find that the climate scenario which best reproduces the observed data includes a N2 ice mid latitude band in the southern hemisphere. We have also studied different haze and P/T ratio profiles: the haze effectively reduces the central flash strength, and a lower P/T ratio both reduces the central flash strength and incurs anomalies in the shoulders of the central flash