Pragmatic language disorder in Parkinson's disease and the potential effect of cognitive reserve

It is known that patients with Parkinson\u2019s Disease (PD) may show deficits in several areas of cognition, including speech and language abilities. One domain of particular interest is pragmatics, which refers to the capacity of using language in context for a successful communication. Several studies showed that some specific aspects of pragmatics \u2013 both in production and in comprehension \u2013 might be impaired in patients with PD. However, a clear picture of pragmatic abilities in PD is still missing, as most of the existing studies focused on specific aspects of the pragmatic competence rather than on sketching a complete pragmatic profile. Moreover, little is known on the potential role of protective factors in compensating the decline of communicative skills as the disease progresses. The present study has two aims: (1) to provide a complete picture of pragmatic abilities in patients with PD, by using a comprehensive battery (Assessment of Pragmatic Abilities and Cognitive Substrates, APACS) and by investigating the relationship with other aspects of cognitive functioning (e.g., working memory and Theory of Mind) and (2) to investigate whether Cognitive Reserve, i.e., the resilience to cognitive impairment provided by life experiences and activities, may compensate for the progressive pragmatic deficits in PD. We found that patients with PD, compared to healthy matched controls, had worse performance in discourse production and in the description of scenes, and that these impairments were tightly correlated with the severity of motor impairment, suggesting reduced intentionality of engaging in a communicative exchange. Patients with PD showed also an impairment in comprehending texts and humor, suggesting a problem in inferring from stories, which was related to general cognitive impairment. Notably, we did not find any significant difference between patients and controls in figurative language comprehension, a domain that is commonly impaired in other neurodegenerative diseases. This might be indicative of a specific profile of pragmatic impairment in patients with PD, worth of further investigation. Finally, Cognitive Reserve measures showed a high degree of association with pragmatic comprehension abilities, suggesting that the modification of life-styles could be a good candidate for compensating the possible problems in understanding the pragmatic aspects of language experienced by patients with PD

steam turbine control valve and actuation system modeling for dynamics analysis

Abstract The paper describes a study conducted on Steam Turbine control valve and actuation systems, which rule the machine final power production and rotational speed. A dynamic model developed in the Matlab/Simulink environment is proposed to support the analysis of the operational stability of the hydro-mechanical system as well as the failure modes that it may face during operation. The model was validated through specific field tests conducted on the actuation system at a cogeneration plant in Nuovo Pignone, Florence. The proposed work also underlines the requirements that new actuation technologies should fulfil in order to meet control valve system performance criteria

Antiplane Stoneley waves propagating at the interface between two couple stress elastic materials

We investigate antiplane Stoneley waves, localized at the discontinuity surface between two perfectly bonded half-spaces. Both half-spaces are elastic linear isotropic and possess a microstructure that is described within the theory of couple stress materials with micro-inertia. We show that the microstructure deeply affects wave propagation, which is permitted under broad conditions. This outcome stands in marked contrast to classical elasticity, where antiplane Stoneley waves are not supported and in-plane Stoneley waves exist only under very severe conditions on the material properties of the bonded half-spaces. Besides, Stoneley waves may propagate only beyond a threshold frequency (cuton), for which an explicit expression is provided. For a given frequency above cuton, this expression lends the admissible range of material parameters that allows propagation (passband). In particular, significant contrast between the adjoining materials is possible, provided that Stoneley waves propagate at high enough frequency. Therefore, micro-inertia plays an important role in determining the features of propagation. Considerations concerning existence and uniqueness of antiplane Stoneley waves are given: it is found that evanescent and decaying/exploding modes are also admitted. Results may be especially useful when accounting for the microstructure in non-destructive testing (NDT) and seismic propagation

A Fuzzy Logic-based Tuning Approach of PID Control for Steam Turbines for Solar Applications

Abstract This work aims at improving the control concept based on PID controller by jointly exploiting experience and knowledge on the system behaviour and artificial intelligence. A Concentrated Solar Power Plant (CSPP) system has been modelled and a stability and performance analysis has been carried out, focusing on power control loop, which is normally based on standard PID. A hybrid fuzzy PID approach is proposed to improve the steam turbine governor action and its performance are compared to the classical PID tuned according to three different approaches. Compared to the classic PID, the PID fuzzy logic controller extends the simplicity of PID and adapts the control action at actual operating condition by providing the system with a sort of "decision-making skill". The possibility to design implementable algorithms on PLC, which have stringent computational speed and memory requirements, has been explicitly taken into account in the developed work

analysis of a simplified steam turbine governor model for power system stability studies

Abstract The present study describes an analysis performed on a simplified Steam Turbine governor model, which is useful for pre-tuning the machine regulation system. A dynamic model has been implemented in two different simulation tools, namely DigSILENT PowerFactory and Matlab/Simulink, to the aim of verifying the suitability of the latter one for power system stability studies. The proposed work paves the way to the wide range of possibilities connected to the integration of the machine governor model with other simulation blocks of a Combined Cycle Plant, by enabling the opportunity for pre-commissioning of the regulation system together with the analysis of the fulfillment of grid code regulations

Influence of severe thermal preconditioning on the bond between carbon FRCM and masonry substrate: Effect of textile pre-impregnation

Fabric-reinforced cementitious matrix (FRCM) composites often include polymer-impregnated bundles to improve the exploitation of the textile mechanical properties. However, organic components may degrade when exposed to elevated temperature. In this paper, the bond behavior of a carbon FRCM applied to a masonry substrate and exposed to a thermal preconditioning up to 300 °C for 250 min is investigated. Tensile tests on the textile and flexural and compression tests on the mortar matrix, as well as single-lap direct shear tests of FRCM-masonry joints with bare and impregnated textiles, are performed. Results show that the polymeric impregnation improves the mechanical properties of the FRCM even after thermal preconditioning

Permeation of Ternary Mixture Containing H2S, CO2 and CH4 in Aquivion® Perfluorosulfonic Acid (PFSA) Ionomer Membranes

Aquivion (R) E87-12S Perfluorosulfonated acid ionomer material (PFSA) has been studied as a membrane technology for natural gas sweetening from CO2 , H2S due to its interesting chemical and mechanical stability and good separation performance for polar compounds in humid environments. In the present work, permeation of the H2S/CO2/CH4 ternary mixture in this short-side PFSA chain was investigated at pressures up to 10 bar, temperatures up to 50 degrees C, and in a range of relative humidity (RH) from 20% to 90%. The results obtain confirm the strong dependence of Aquivion (R) on water activity and temperature, and its ability to separate gases based on their water solubility without substantial differences between pure and mixed gas experiments. Indeed, even when tested in ternary mixture, the permeation behavior remains similar to that observed for pure components and binary mixtures. In particular, the permeability of H2S is higher than that of CO(2 )and methane CH4, reaching values of 500 Barrer at 50 degrees C and 80% RH, against 450 and 23 Barrer for the other two gases respectively. Additionally, when tested at higher pressures of up to 10 bar under humid conditions, the membrane properties remained largely unchanged, thus confirming the overall stability and durability of Aquivion (R) E87-12S in acid environments

Analytical Approach for Modelling the Pull-Out Mechanism of Recycled Synthetic Fibres in Fibre-Reinforced Concrete (FRC)

This study presents a simple one-dimensional analytical model describing the pull-out process of an elastic fibre embedded in a cement matrix, which captures the ductile behaviour of Fibre Reinforced Concrete (FRC) elements. The shear stress arising at the frictional interface between fibre and matrix during the pull-out is assumed to increase with the slippage distance, as a consequence of the growing abrasion of the fibre surface. The equilibrium conditions between the external axial load and the interfacial shear stress are imposed with reference to the undeformed configuration. The model is validated through comparison with both experimental data obtained by testing partially recycled polymeric fibres embedded in a cement matrix, and several datasets available in the literature comprising polypropylene fibres with and without silica coatings. The proposed model can properly describe the response of synthetic fibres that exhibit considerable axial elongation and slip-hardening interface behaviour. However, it may also predict the non-linear relation between the tensile load and the fibre displacement for different kinds of fibre, by setting adequately the constitutive parameters

Employing limestone and calcined clay for preserving the strain-hardening response of PET fiber-reinforced cementitious composites

The degradation of polyethylene terephthalate (PET) fibers in alkaline environments limits their use in strain-hardening cementitious composites (SHCC). Prolonged PET exposure to alkaline environments has a detrimental effect on its mechanical performance, mainly due to the physicochemical transformation caused by alkaline hydrolysis. This study presents a tailored cementitious matrix design containing high amounts of limestone and calcined clay, replacing 75 wt% of Portland cement, to attain and maintain the strain-hardening response of composites incorporating PET fibers as dispersed reinforcement. Analytical and mechanical tests were carried out at different curing ages, ranging from 7 to 60 days, to study the effects of aging on virgin PET fibers, both within the matrix and outside it (in the pore solution). The results showed a pronounced degradation of the PET fibers in the test pore solution at pH 12.5, manifested by a progressive reduction in the load-bearing capacity of the individual fibers with prolonged immersion. Conversely, when the PET fibers were aged in-matrix under laboratory conditions and tested under tension, the performance of the corresponding composites showed resilience to aging, exhibiting reasonable tensile strength and remarkable strain capacities that exceeded 4 %

Experimental and analytical analysis of the bond alteration of impregnated carbon fibre reinforcements embedded in alkali-activated concrete at elevated temperatures

The restricted operating temperature range of fibre-reinforced polymer (FRP) systems for upgrading and retrofitting reinforced concrete structures is among the key limiting factors of this technology. Indeed, an alternative reinforcing system, known as Mineral-impregnated Carbon-Fibre (MCF), has recently emerged to address this issue. This paper presents an experimental investigation of the performance of MCF systems embedded in fine-grained, Alkali-Activated Concrete (AAC), which have been pre-heated at 100 °C (or 200 °C) and then tested in pull-out at the target temperature. For the purpose of assessing the bond quality against thermal exposure, results are compared with the control group (ambient temperature 20 °C), as well as with an epoxy-impregnated commercial roving. In addition, specimens are characterised at the fibre-to-matrix interface by microscopy and by physical–chemical analytical techniques. Experimental data are fitted onto a one-dimensional stress-and-friction analytical model to determine the characteristic properties of the temperature-dependent bond–slip behaviour of MCFs. Findings suggest enhanced chemical compatibility and reinforcing capabilities at elevated temperature for MCFs, primarily ascribed to the impregnation quality and to the AAC capacity to withstand thermal strain