982 research outputs found
The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice.
The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis. We examined the effect of roflumilast, a selective PDE4 inhibitor marketed for severe COPD, and the investigational compound pumafentrine, a dual PDE3/PDE4 inhibitor, in the preventive dextran sodium sulfate (DSS)-induced colitis model. The clinical score, colon length, histologic score and colon cytokine production from mice with DSS-induced colitis (3.5% DSS in drinking water for 11 days) receiving either roflumilast (1 or 5 mg/kg body weight/d p.o.) or pumafentrine (1.5 or 5 mg/kg/d p.o.) were determined and compared to vehicle treated control mice. In the pumafentrine-treated animals, splenocytes were analyzed for interferon-γ (IFNγ) production and CD69 expression. Roflumilast treatment resulted in dose-dependent improvements of clinical score (weight loss, stool consistency and bleeding), colon length, and local tumor necrosis factor-α (TNFα) production in the colonic tissue. These findings, however, were not associated with an improvement of the histologic score. Administration of pumafentrine at 5 mg/kg/d alleviated the clinical score, the colon length shortening, and local TNFα production. In vitro stimulated splenocytes after in vivo treatment with pumafentrine showed a significantly lower state of activation and production of IFNγ compared to no treatment in vivo. These series of experiments document the ameliorating effect of roflumilast and pumafentrine on the clinical score and TNF expression of experimental colitis in mice
Random walks - a sequential approach
In this paper sequential monitoring schemes to detect nonparametric drifts
are studied for the random walk case. The procedure is based on a kernel
smoother. As a by-product we obtain the asymptotics of the Nadaraya-Watson
estimator and its as- sociated sequential partial sum process under
non-standard sampling. The asymptotic behavior differs substantially from the
stationary situation, if there is a unit root (random walk component). To
obtain meaningful asymptotic results we consider local nonpara- metric
alternatives for the drift component. It turns out that the rate of convergence
at which the drift vanishes determines whether the asymptotic properties of the
monitoring procedure are determined by a deterministic or random function.
Further, we provide a theoretical result about the optimal kernel for a given
alternative
Early N-terminal pro-B-type natriuretic peptide is associated with cardiac complications and function during pregnancy in congenital heart disease
Background: Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels at 20 weeks’ gestation predict adverse cardiovascular (CV) complications during pregnancy in women with congenital heart disease (CHD). To improve early risk assessment in these women, we investigated the predictive value of first-trimester NT-proBNP for CV complications and its association with ventricular function during pregnancy. Methods: Pregnant women with CHD, previously enrolled in a prospective national study or evaluated by an identical protocol, were included. Clinical data, echocardiographic evaluation and NT-proBNP measurements were obtained at 12, 20 and 32 weeks’ gestation. Elevated NT-proBNP was defined as > 235 pg/ml (95th percentile reference value of healthy pregnant women in the literature). Results: We examined 126 females (mean age 29 years). Elevated NT-proBNP at 12 weeks was associated with CV complications (n = 7, 5.6%, odds ratio 10.9, p = 0.004). Arrhythmias were the most common complication (71%). The negative predictive value of low NT-proBNP to exclude CV complications was 97.2%. In women with CV complications, NT-proBNP levels remained high throughout pregnancy, while a decrease was seen in women without CV complications (p < 0.001 for interaction between group and time). At 12 weeks, higher NT-proBNP levels were associated with impaired subpulmonary ventricular function (p < 0.001) and also with a decline in subpulmonary ventricular function later in pregnancy (p = 0.012). Conclusions: In this study, first-trimester NT-proBNP levels were associated with adverse CV complications and a decline in subpulmonary ventricular function later in pregnancy in women with CHD. Early NT-proBNP evaluation is useful for tailored care in pregnant women with CHD
Large-Amplitude Ultraviolet Variations in the RR Lyrae Star ROTSE-I J143753.84+345924.8
The NASA Galaxy Evolution Explorer (GALEX) satellite has obtained
simultaneous near and far ultraviolet light curves of the ROTSE-I Catalog RR
Lyrae ab-type variable star J143753.84+345924.8. A series of 38 GALEX Deep
Imaging Survey observations well distributed in phase within the star's
0.56432d period shows an AB=4.9mag variation in the far UV (1350-1750A) band
and an AB=1.8mag variation in the near UV (1750-2750A) band, compared with only
a 0.8mag variation in the broad, unfiltered ROTSE-I (4500-10000A) band. These
GALEX UV observations are the first to reveal a large RR Lyrae amplitude
variation at wavelengths below 1800A. We compare the GALEX and ROTSE-I
observations to predictions made by recent Kurucz stellar atmosphere models. We
use published physical parameters for the comparable period (0.57433d),
well-observed RR Lyrae star WY Antliae to compute predicted FUV, NUV, and
ROTSE-I light curves for J143753.84+345924.8. The observed light curves agree
with the Kurucz predictions for [Fe/H]=-1.25 to within AB=0.2mag in the GALEX
NUV and ROTSE-I bands, and within 0.5mag in the FUV. At all metallicities
between solar and one hundredth solar, the Kurucz models predict 6-8mag of
variation at wavelengths between 1000-1700A. Other variable stars with similar
temperature variations, such as Cepheids, should also have large-amplitude FUV
light curves, observable during the ongoing GALEX imaging surveys.Comment: This paper will be published as part of the Galaxy Evolution Explorer
(GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of
papers will be available at http:/www.galex.caltech.edu/PUBLICATIONS after
November 22, 200
The GALEX UV luminosity function of the cluster of galaxies Abell 1367
We present the GALEX NUV (2310 A) and FUV (1530 A) galaxy luminosity
functions of the nearby cluster of galaxies A1367 in the magnitude range -20.3<
M_AB < -13.3. The luminosity functions are consistent with previous (~ 2 mag
shallower) estimates based on the FOCA and FAUST experiments, but display a
steeper faint-end slope than the GALEX luminosity function for local field
galaxies. Using spectro-photometric optical data we select out star-forming
systems from quiescent galaxies and study their separate contributions to the
cluster luminosity function. We find that the UV luminosity function of cluster
star-forming galaxies is consistent with the field. The difference between the
cluster and field LF is entirely due to the contribution at low luminosities
(M_AB >-16 mag) of non star-forming, early-type galaxies that are significantly
over dense in clusters.Comment: 4 pages, 4 figures, 1 table. Accepted for publication in
Astrophysical Journal Letter
GALEX UV Spectroscopy and Deep Imaging of LIRGs in the ELAIS S1 field
The ELAIS S1 field was observed by GALEX in both its Wide Spectroscopic and
Deep Imaging Survey modes. This field was previously observed by the Infrared
Space Observatory and we made use of the catalogue of multi-wavelength data
published by the ELAIS consortium to select galaxies common to the two samples.
Among the 959 objects with GALEX spectroscopy, 88 are present in the ELAIS
catalog and 19 are galaxies with an optical spectroscopic redshift. The
distribution of redshifts covers the range . The selected galaxies
have bolometric IR luminosities (deduced from the flux using ISOCAM) which means that we cover a wide range of galaxies from
normal to Ultra Luminous IR Galaxies. The mean () UV luminosity (not
corrected for extinction) amounts to
L_\sun for the low-z () sample. The UV slope (assuming
) correlates with the GALEX FUV-NUV color if
the sample is restricted to galaxies below . Taking advantage of the
UV and IR data, we estimate the dust attenuation from the IR/UV ratio and
compare it to the UV slope . We find that it is not possible to uniquely
estimate the dust attenuation from for our sample of galaxies. These
galaxies are highly extinguished with a median value .
Once the dust correction applied, the UV- and IR-based SFRs correlate. For the
closest galaxy with the best quality spectrum, we see a feature consistent with
being produced by a bump near 220nm in the attenuation curve.Comment: This paper has been published as part of the GALEX ApJL Special Issue
(ApJ 619, L63
Tema Con Variazioni: Quantum Channel Capacity
Channel capacity describes the size of the nearly ideal channels, which can
be obtained from many uses of a given channel, using an optimal error
correcting code. In this paper we collect and compare minor and major
variations in the mathematically precise statements of this idea which have
been put forward in the literature. We show that all the variations considered
lead to equivalent capacity definitions. In particular, it makes no difference
whether one requires mean or maximal errors to go to zero, and it makes no
difference whether errors are required to vanish for any sequence of block
sizes compatible with the rate, or only for one infinite sequence.Comment: 32 pages, uses iopart.cl
Star formation in the nearby universe: the ultraviolet and infrared points of view
This work presents the main ultraviolet (UV) and far-infrared (FIR)
properties of two samples of nearby galaxies selected from the GALEX (\AA, hereafter NUV) and IRAS (m) surveys respectively.
They are built in order to get detection at both wavelengths for most of the
galaxies. Star formation rate (SFR) estimators based on the UV and FIR
emissions are compared. Systematic differences are found between the SFR
estimators for individual galaxies based on the NUV fluxes corrected for dust
attenuation and on the total IR luminosity. A combined estimator based on NUV
and IR luminosities seems to be the best proxy over the whole range of values
of SFR. Although both samples present similar average values of the birthrate
parameter b, their star-formation-related properties are substantially
different: NUV-selected galaxies tend to show larger values of for lower
masses, SFRs and dust attenuations, supporting previous scenarios for the star
formation history (SFH). Conversely, about 20% of the FIR-selected galaxies
show high values of , SFR and NUV attenuation. These galaxies, most of them
being LIRGs and ULIRGs, break down the downsizing picture for the SFH, however
their relative contribution per unit volume is small in the local Universe.
Finally, the cosmic SFR density of the local Universe is estimated in a
consistent way from the NUV and IR luminosities.Comment: 43 pages, 13 figures, accepted for publication in Astrophysical
Journal Supplement Serie
The SCOUT-O3 Darwin Aircraft Campaign: rationale and mateorology
An aircraft measurement campaign involving the Russian high-altitude aircraft M55 Geophysica and the German DLR Falcon was conducted in Darwin, Australia in November and December 2005 as part of the European integrated
project SCOUT-O3. The overall objectives of the campaign were to study the transport of trace gases through the tropical tropopause layer (TTL), mechanisms of dehydration close to the tropopause, and the role of deep convection in these processes. In this paper a detailed roadmap of the
campaign is presented, including rationales for each flight, and an analysis of the local and large-scale meteorological context in which they were embedded. The campaign took place during the pre-monsoon season which is characterized by a pronounced diurnal evolution of deep convection including a mesoscale system over the Tiwi Islands north of Darwin known as �\x83¢Â�Â�HectorâÂ�Â�. This allowed studying in detail the role of deep convection in structuring the tropical tropopause region, in situ sampling convective overshoots above storm anvils, and probing the structure of anvils and cirrus clouds by Lidar and a suite of in situ instruments onboard the two aircraft. The large-scale flow during the first half of the campaign was such that local flights, away from convection, sampled air masses downstream of the âÂ�Â�cold trapâÂ�Â� region over Indonesia.
Abundant cirrus clouds enabled the study of active dehydration, in particular during two TTL survey flights. The campaign period also encompassed a Rossby wave breaking event transporting stratospheric air to the tropical middle
troposphere and an equatorial Kelvin wave modulating tropopause temperatures and hence the conditions for dehydration
GALEX UV Color-Magnitude Relations and Evidence for Recent Star Formation in Early-type Galaxies
We have used the GALEX UV photometric data to construct a first
near-ultraviolet (NUV) color-magnitude relation (CMR) for the galaxies
pre-classified as early-type by SDSS studies. The NUV CMR is a powerful tool
for tracking the recent star formation history in early-type galaxies, owing to
its high sensitivity to the presence of young stellar populations. Our NUV CMR
for UV-weak galaxies shows a well-defined slope and thus will be useful for
interpreting the restframe NUV data of distant galaxies and studying their star
formation history. Compared to optical CMRs, the NUV CMR shows a substantially
larger scatter, which we interpret as evidence of recent star formation
activities. Roughly 15% of the recent epoch (z < 0.13) bright (M[r] < -22)
early-type galaxies show a sign of recent (< 1Gyr) star formation at the 1-2%
level (lower limit) in mass compared to the total stellar mass. This implies
that low level residual star formation was common during the last few billion
years even in bright early-type galaxies.Comment: This paper will be published as part of the Galaxy Evolution Explorer
(GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of
papers will be available at http://www.galex.caltech.edu/PUBLICATIONS/ after
November 22, 200
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