The neurocognition of linguistic conflict resolution: evidence from brain oscillations, ERPs, and source modelling

The ability to express thought in language, to communicate, and to rapidly understand who did what to whom is a highly complex cognitive skill and ultimately the cognitive trait that defines us as being human. For the most part, language comprehension runs very smoothly and people perform it extremely quickly and efficiently. One might think this is nothing exceptional, were it not for the fact that everyday speech contains plenty of ambiguities, speech errors, and otherwise conflicting or interfering information. Similar to any other cognitive system, the language system is fitted out with mechanisms that detect conflicts and trigger compensating adjustments ‘on-the-fly’ in order to make sense of what has been said. Inevitably, language comprehension requires a combination of automatic and controlled processes and, depending on the context, we engage in both to varying degrees. Historically, linguistic conflict resolution has been investigated regarding to what extent linguistic modules such as ‘syntax’ and ‘semantics’ contribute to the process. In this thesis I take a step away from the traditional approach towards the question how the mechanisms underlying linguistic conflict resolution fit into domain-general cognition. It has been shown that controlled processing reliably results in activation of large-scale networks throughout the cortex. Importantly, neuroimaging studies have shown that the crucial brain region that enables us to flexibly make adjustments is the prefrontal cortex (PFC). In this thesis I present four case studies that investigated brain oscillations (as recorded in the EEG and MEG signal) in the time-frequency- (TFR), amplitude-time- (ERP), and source domain to determine how the language system relates to general executive functions. The materials employed structures that are amongst the most well-studied in psycholinguistic research: locally ambiguous garden-path sentences (e.g. “The nurse examined by the doctor was not on duty”), gender-agreement mismatches in anaphora and cataphora (e.g.“The king left London after reminding himself/herself about the letter”/ “After reminding himself/herself about the letter, the king left London.”), and syntactically complex garden-path sentences (“The receptionist realized that the nurse examined by the doctor was not on duty.”).The results in this thesis support the notion that there is indeed a connection between the language system and general executive functions during linguistic conflict resolution. Still, there are also situations where specialized ‘modules’ perform conflict resolution in a highly automatised fashion, particularly when contextual information sufficiently cues future input. However, as soon as increased uncertainty comes into play or capacity limits are reached, the brain appears to rely on extremely flexible mechanisms in prefrontal cortex regions

Can context affect gender processing? ERP differences between definitional and stereotypical gender

Previous research using Eye-Tracking and ERP has shown that readers experience processing difficulty when an anaphor (herself) refers to a gender-mismatching antecedent (minister). The mismatch-effect is due to a clash between the gender of the pronoun and the gender of the co-referential noun. We report two EEG experiments using anaphora (Experiment 1) and cataphora (Experiment 2) sen-tences, designed to investigate the processing differences between stereotypical (minister) and definitional (king) gender role nouns. Consistent with previous findings (Osterhout et al., 1997), our results reveal similar mismatching effects for these noun types in anaphora. Critically, however, in cataphora, where the pronoun precedes its co-referring noun, diverging ERP signatures are revealed. Differences in an early interval suggest fast "gender-coercing" for stereotypical nouns while effects in a later interval are likely to reflect gender mismatch pro-cessing in definitional nouns. These findings suggest that discourse constraints modulate the processing of these two noun types in different ways

Listening to limericks: a pupillometry investigation of perceivers’ expectancy

What features of a poem make it captivating, and which cognitive mechanisms are sensitive to these features? We addressed these questions experimentally by measuring pupillary responses of 40 participants who listened to a series of Limericks. The Limericks ended with either a semantic, syntactic, rhyme or metric violation. Compared to a control condition without violations, only the rhyme violation condition induced a reliable pupillary response. An anomaly-rating study on the same stimuli showed that all violations were reliably detectable relative to the control condition, but the anomaly induced by rhyme violations was perceived as most severe. Together, our data suggest that rhyme violations in Limericks may induce an emotional response beyond mere anomaly detection

What is R? A graph drawer’s perspective?

No abstract available

Exploiting scanning surveillance data to inform future strategies for the control of endemic diseases: the example of sheep scab

Scanning surveillance facilitates the monitoring of many endemic diseases of livestock in Great Britain, including sheep scab, an ectoparasitic disease of major welfare and economic burden. There is, however, a drive to improve the cost-effectiveness of animal health surveillance, for example by thoroughly exploiting existing data sources. By analysing the Veterinary Investigation Diagnosis Analysis (VIDA) database, this study aimed to enhance the use of existing scanning surveillance data for sheep scab to identify current trends, highlighting geographical “hotspots” for targeted disease control measures, and identifying a denominator to aid the interpretation of the diagnostic count data. Furthermore, this study collated and assessed the impact of past targeted disease control initiatives using a temporal aberration detection algorithm, the Farrington algorithm, to provide an evidence base towards developing cost-effective disease control strategies. A total of 2,401 positive skin scrapes were recorded from 2003 to 2018. A statistically significant decline in the number of positive skin scrapes diagnosed (p < 0.001) occurred across the study period, and significant clustering was observed in Wales, with a maximum of 47 positive scrapes in Ceredigion in 2007. Scheduled ectoparasite tests was also identified as a potential denominator for the interpretation of positive scrapes by stakeholders. Across the study period, 11 national disease control initiatives occurred: four in Wales, three in England, and four in Scotland. The majority (n = 8) offered free diagnostic testing while the remainder involved knowledge transfer either combined with free testing or skills training and the introduction of the Sheep Scab (Scotland) Order 2010. The Farrington algorithm raised 20 alarms of which 11 occurred within a period of free testing in Wales and one following the introduction of the Sheep Scab (Scotland) Order 2010. In summary, our analysis of the VIDA database has greatly enhanced our knowledge of sheep scab in Great Britain, firstly by identifying areas for targeted action and secondly by offering a framework to measure the impact of future disease control initiatives. Importantly this framework could be applied to inform future strategies for the control of other endemic diseases

Visualization for epidemiological modelling: challenges, solutions, reflections and recommendations.

From Europe PMC via Jisc Publications RouterHistory: epub 2022-08-15, ppub 2022-10-01Publication status: PublishedFunder: UK Research and Innovation; Grant(s): ST/V006126/1, EP/V054236/1, EP/V033670/1We report on an ongoing collaboration between epidemiological modellers and visualization researchers by documenting and reflecting upon knowledge constructs-a series of ideas, approaches and methods taken from existing visualization research and practice-deployed and developed to support modelling of the COVID-19 pandemic. Structured independent commentary on these efforts is synthesized through iterative reflection to develop: evidence of the effectiveness and value of visualization in this context; open problems upon which the research communities may focus; guidance for future activity of this type and recommendations to safeguard the achievements and promote, advance, secure and prepare for future collaborations of this kind. In describing and comparing a series of related projects that were undertaken in unprecedented conditions, our hope is that this unique report, and its rich interactive supplementary materials, will guide the scientific community in embracing visualization in its observation, analysis and modelling of data as well as in disseminating findings. Equally we hope to encourage the visualization community to engage with impactful science in addressing its emerging data challenges. If we are successful, this showcase of activity may stimulate mutually beneficial engagement between communities with complementary expertise to address problems of significance in epidemiology and beyond. See https://ramp-vis.github.io/RAMPVIS-PhilTransA-Supplement/. This article is part of the theme issue 'Technical challenges of modelling real-life epidemics and examples of overcoming these'

FAIR Data Pipeline: provenance-driven data management for traceable scientific workflows

Modern epidemiological analyses to understand and combat the spread of disease depend critically on access to, and use of, data. Rapidly evolving data, such as data streams changing during a disease outbreak, are particularly challenging. Data management is further complicated by data being imprecisely identified when used. Public trust in policy decisions resulting from such analyses is easily damaged and is often low, with cynicism arising where claims of "following the science" are made without accompanying evidence. Tracing the provenance of such decisions back through open software to primary data would clarify this evidence, enhancing the transparency of the decision-making process. Here, we demonstrate a Findable, Accessible, Interoperable and Reusable (FAIR) data pipeline developed during the COVID-19 pandemic that allows easy annotation of data as they are consumed by analyses, while tracing the provenance of scientific outputs back through the analytical source code to data sources. Such a tool provides a mechanism for the public, and fellow scientists, to better assess the trust that should be placed in scientific evidence, while allowing scientists to support policy-makers in openly justifying their decisions. We believe that tools such as this should be promoted for use across all areas of policy-facing research

Manipulation of contact network structure and the impact on foot-and-mouth disease transmission

As evidenced by the 2001 foot-and-mouth disease (FMD) epidemic in the UK, this can involve transmission over large geographical distances and can result in major economic loss. One consequence of the FMD epidemic was the introduction of mandatory livestock movement restrictions: a 13-day standstill in Scotland for cattle and sheep after moving livestock onto a farm (allowing many exemptions) and a 6-day standstill for cattle and sheep in England and Wales (with minor exemptions, e.g. direct movements to slaughter). Such standstills are known to be effective but commercial considerations result in pressures to relax them. When contemplating legislative changes such as a change in length of movement restrictions we need to consider the consequent effect these could have on the emergent properties of the system, i.e. the network structure itself. In this study, we investigate how disease dynamics change when the local contact structure of the recorded livestock movement network in Scotland is altered through rewiring movements between premises. The network rewiring used here changes the structure of the recorded trade network through a combination of altered movement restrictions and redirection of movements between holdings and markets to avoid nonsensical activity (e.g. movements to markets on days when they are inactive) while conserving other characteristics (e.g. movement date as closely as possible and market sales of the correct animal production type). Rewiring results in networks with higher clustering coefficients and lower network density. The impact of rewiring on a hypothetical foot-and-mouth disease outbreak in Scotland was assessed by stochastic simulation, considering scenarios with and without exemptions to the standstill rules. As expected, rewiring leads to a decrease in outbreak size and - if standstill exemptions are prohibited – higher probability of smaller outbreaks. Without exemptions, a shorter movement standstill is almost as effective as a longer standstill period, indicating that a simpler biosecurity system would offer minimal additional risk for FMD. These results suggest that explicitly manipulating the contact network structure in a sensible way has the potential to significantly impact disease control

Visualization for epidemiological modelling: challenges, solutions, reflections and recommendations

From The Royal Society via Jisc Publications RouterHistory: received 2021-10-14, accepted 2022-03-18, pub-electronic 2022-08-15, pub-print 2022-10-03Article version: VoRPublication status: PublishedFunder: UK Research and Innovation; Id: http://dx.doi.org/10.13039/100014013; Grant(s): EP/V033670/1, EP/V054236/1, ST/V006126/1We report on an ongoing collaboration between epidemiological modellers and visualization researchers by documenting and reflecting upon knowledge constructs—a series of ideas, approaches and methods taken from existing visualization research and practice—deployed and developed to support modelling of the COVID-19 pandemic. Structured independent commentary on these efforts is synthesized through iterative reflection to develop: evidence of the effectiveness and value of visualization in this context; open problems upon which the research communities may focus; guidance for future activity of this type and recommendations to safeguard the achievements and promote, advance, secure and prepare for future collaborations of this kind. In describing and comparing a series of related projects that were undertaken in unprecedented conditions, our hope is that this unique report, and its rich interactive supplementary materials, will guide the scientific community in embracing visualization in its observation, analysis and modelling of data as well as in disseminating findings. Equally we hope to encourage the visualization community to engage with impactful science in addressing its emerging data challenges. If we are successful, this showcase of activity may stimulate mutually beneficial engagement between communities with complementary expertise to address problems of significance in epidemiology and beyond. See https://ramp-vis.github.io/RAMPVIS-PhilTransA-Supplement/. This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’