1,238 research outputs found
Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances
Recovering the CMB Signal with Machine Learning
The cosmic microwave background (CMB), carrying the inhomogeneous information
of the very early universe, is of great significance for understanding the
origin and evolution of our universe. However, observational CMB maps contain
serious foreground contaminations from several sources, such as galactic
synchrotron and thermal dust emissions. Here, we build a deep convolutional
neural network (CNN) to recover the tiny CMB signal from various huge
foreground contaminations. Focusing on the CMB temperature fluctuations, we
find that the CNN model can successfully recover the CMB temperature maps with
high accuracy, and that the deviation of the recovered power spectrum
is smaller than the cosmic variance at . We then apply this method to
the current Planck observation, and find that the recovered CMB is quite
consistent with that disclosed by the Planck collaboration, which indicates
that the CNN method can provide a promising approach to the component
separation of CMB observations. Furthermore, we test the CNN method with
simulated CMB polarization maps based on the CMB-S4 experiment. The result
shows that both the EE and BB power spectra can be recovered with high
accuracy. Therefore, this method will be helpful for the detection of
primordial gravitational waves in current and future CMB experiments. The CNN
is designed to analyze two-dimensional images, thus this method is not only
able to process full-sky maps, but also partial-sky maps. Therefore, it can
also be used for other similar experiments, such as radio surveys like the
Square Kilometer Array.Comment: 19 pages, 25 figures, and 3 tables, ApJS, in press. The code
repository is available at https://github.com/Guo-Jian-Wang/cmbNNC
A saúde mental é o fator mais importante que influencia a qualidade de vida de idosos deixados para trás quando as famílias emigram da China rural
OBJECTIVES: to investigate the quality of life and the associated factors on left behind elderly in rural China. METHOD: the research was conducted cluster sampling to select 456 elderly left behind when family members migrated out of rural China to participate in a cross-sectional study by completing a general data questionnaire and Quality of Life questionnaire. RESULTS: 91.5% of the elderly requested psychological counseling and education. For the elderly, scores for mental health (39.56±13.73) were significantly lower compared with Chinese standard data (61.6±13.7) (POBJETIVOS: investigar la calidad de vida y los factores asociados a los adultos mayores que se quedan en las zonas rurales de China. MÉTODO: la investigación se realizó por medio de muestreo por conglomerados para seleccionar 456 adultos mayores que se quedaron cuando los miembros de la familia emigraron de zonas rurales de China, para participar en un estudio de corte transversal, completando un cuestionario de datos generales y cuestionario de calidad de vida. RESULTADOS: el 91.5% de los adultos mayores solicitó asistencia psicológica y educación. Para los adultos mayores, las puntuaciones de salud mental (39.56±13.73) fueron significativamente más bajos en comparación con los datos estándar de China (61.6±13.7) (pOBJETIVOS: investigar a qualidade de vida e fatores associados de idosos deixados para trás na China rural. MÉTODO: foi realizada amostragem por conglomerado para selecionar 456 idosos deixados para trás quando os membros da família emigram da China rural. Este é um estudo transversal com preenchimento de um questionário de dados gerais e de qualidade de vida. RESULTADOS: 91,5% dos idosos convidados solicitaram aconselhamento e educação psicológicos. Para os idosos, os escores de saúde mental (39,56±13,73) foram significativamente menores em comparação aos dados padrões chineses (61,6±13,7) (
The association of a single nucleotide polymorphism in the promoter region of the LAMA1 gene with susceptibility to Chinese high myopia
Purpose: High myopia is a severe hereditary ocular disease leading to blindness. LAMA1 (alpha subunit of laminin) is a promising candidate gene for high myopia present in the MYP2 (myopia 2) region. The purpose of this study was to determine if high myopia is associated with single nucleotide polymorphism (SNP) variants in LAMA1 in Chinese subjects. Methods: Ninety-seven Chinese subjects with high myopia and ethnically and sexually matched 103 normal controls were enrolled. Genomic DNA was prepared from peripheral blood. The 5 SNPs of LAMA1 were analyzed using PCR and SNaPshot. Allele frequencies were tested for Hardy-Weinberg disequilibrium. The genotype and allele frequencies were evaluated using the χ2 tests or the Fisher exact tests. Results: One of the 5 SNPs showed a significant difference between patients and control subjects (rs2089760: pgenotype=0.005, pallel=0.003). There were no statistically significant differences between patients and control subjects for the other four SNPs: rs566655, rs11664063, rs607230, and rs3810046. Conclusions: Our results indicate that the polymorphism of rs2089760, located in the promoter region of LAMA1, may be associated with high myopia in the Chinese population and should be investigated further. © 2011 Molecular Vision.link_to_subscribed_fulltex
The influence of net-quarks on the yields and rapidity spectra of identified hadrons
Within a quark combination model, we study systematically the yields and
rapidity spectra of various hadrons in central Au+Au collisions at
GeV. We find that considering the difference in rapidity
between net-quarks and newborn quarks, the data of multiplicities, rapidity
distributions for , , and, in particular the
ratios of charged antihadron to hadron as a function of rapidity, can be well
described. The effect of net-quarks on various hadrons is analysed, and the
rapidity distributions for , ,
, ()
and are predicted. We discuss
the rapidity distribution of net-baryon, and find that it reflects exactly the
energy loss of colliding nuclei.Comment: 8 pages, 7 figure
Centrality dependence of spectra for identified hadrons in Au+Au and Cu+Cu collisions at GeV
The centrality dependence of transverse momentum spectra for identified
hadrons at midrapidity in Au+Au collisions at GeV is
systematically studied in a quark combination model. The
spectra of , , and in
different centrality bins and the nuclear modification factors () for
these hadrons are calculated. The centrality dependence of the average
collective transverse velocity for the hot and dense quark matter
is obtained in Au+Au collisions, and it is applied to a relative smaller Cu+Cu
collision system. The centrality dependence of spectra and
the for , and in Cu+Cu collisions at
GeV are well described. The results show that is only a function of the number of participants and it is
independent of the collision system.Comment: 7 pages, 6 figure
The Basic Differential Equations of Self-Anchored Cable-Stayed Suspension Bridge
The static behavior of self-anchored cable-stayed suspension bridge under vertical load is described with the continuum method. Based on the partition generalized variation principle, considering the compression-bending coupling effect of the main girder and the tower, the large displacement incomplete generalized potential energy functional of three-span self-anchored cable-stayed suspension bridge is established. Then, the basic differential equations of self-anchored cable-stayed suspension bridge are derived through constraint variation. Taking a self-anchored cable-stayed suspension bridge with main span 100 m, for example, the results by the proposed analytic method agree with that of numerical analysis. Therefore, the basic differential equations proposed in this paper could be applied to the preliminary analysis of self-anchored cable-stayed suspension bridge. The equations also provide a theoretical basis to describe the static behavior of this type of bridge
Selenium‐doping induced two antiferromagnetic transitions in thiospinel compounds CuCo₂S_(4‐x)Se_x (0 ≤ x ≤ 0.8)
A series of copper thiospinels compounds, CuCo₂S_(4‐x)Se_x (x = 0, 0.2, 0.4, 0.6, 0.8), have been successfully synthesized by solid state reaction and their structure and magnetic properties have been studied. The Rietveld refinements of X‐Ray diffractions indicate that both the lattice constants and the nearest neighbor Cu‐Cu distances increase with increasing selenium doping. A weakly antiferromagnetic transition occurring at about 4 K is observed in CuCo₂S₄. Two antiferromagnetic transitions at about 3.5 K and 6 K are observed in selenium‐doped samples, which suggest that the exchange couplings associated with Cu‐S(Se)‐Cu and Cu‐Se(S)‐Cu, respectively, are responsible for the two antiferromagnetic transitions. Detailed analysis of the experimental results further indicate that the nearest‐neighbor molecular field coefficient is comparable to the next‐neighbor molecular field coefficient. We propose a reasonable model to explain this phenomenon
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