NEED AND IMPORTANCE OF VYAYAMA IN PRESENT ERA: A CRITICAL REVIEW

Ayurveda dealing as a science of life speaks about physical, mental and social health. In Ayurvedic science Vyayama is included in daily regimen for the purpose of staying healthy. As per World Health Organization data, lack of physical activity is responsible for 6% deaths globally. Exercise helps in metabolism of free fatty acids and plays an important role to overcome obesity and obesity related disorders like type 2 diabetes and cardiac disease like CVD (cardiovascular disease) and many more other disorders like breast cancer, colon cancer, dementia and depression. In Ayurvedic aspect Vyayama stimulate Agni which prevents formation of Ama so it is helpful in prevention of many disorder. In this review it is described that Vyayama or physical activity is necessary for an individual in today’s life and Vyayama or physical activity works for staying healthy and longevity

Role of Toll-Like Receptor (TLR)-Signaling in Cancer Progression and Treatment

Toll-like receptors (TLRs) are the most essential pattern recognition receptors in mediating the effects of innate immunity. It plays a pivotal role in inducing immune response against a number of pathogens, various diseases conditions including pathogenesis of cancer. Inflammation is often associated with the development and progression of most of cancer, where TLRs interplay very crucial roles. Moreover, TLRs activation can impact the initiation, progression and treatment of cancer by modulating the inflammatory microenvironment. Rapidly growing number of evidences related to TLRs function and expression in cancer cells, suggests its critical association with chemoresistance and tumourigenesis. The current chapter describes the development of various agonist and antagosist for TLRs and their application in cancer therapeutics. The aim of this book chapter is to highlights basic features of TLRs, and its role in cancer progression. It also addresses, how a defect in the TLRs signaling pathway can contributes towards carcinogenesis and recent development of cancer therapeutics that target TLR signaling pathways

Towards a New Era in the Management of Large Periapical Lesion in Permanent Tooth Using Stemcells: A 2-Year Clinical Application Report

Stem cells are considered as the principal source of differentiated cells. In the past few years, the research on the stem cell in various fields had shown success, but the stem cell-based therapies in the dentistry had confined to a particular extent. The present case report was aimed to evaluate the efficacy of stem cells from human exfoliated deciduous teeth (SHED) in the management of a large periapical lesion. A 12-year-old girl reported with a chief complaint of pain in the lower right back tooth region since 5 days. Intraoral examination revealed a deep occlusal cavity in relation to tooth#46 with tenderness on percussion. Radiograph examination revealed periapical radiolucency measuring 1.8×1.0cm in size with perforation at the floor of the pulp chamber in relation to 46. A deciduous tooth from the same child was collected to isolate stem cells. After access opening for tooth #46, pulp was extirpated and a thick mucoperiosteal flap was raised. This was followed by homing of SHED into the periapical area through the window created in the buccal cortical plate and into the root canals of tooth #46 until the orifice. The access cavity was sealed with glass ionomer cement. The patient was subjected to evaluation at regular intervals i.e., two weeks, four months, twelve months, and twenty-four months. The case treated demonstrated complete resolution of periapical radiolucency in the fourth-month review with a positive response to electric pulp testing. This clinical application report concludes that SHED can be effective in treating the periapical lesions in permanent teeth

A bibliography of parasites and diseases of marine and freshwater fishes of India

With the increasing demand for fish as human food, aquaculture both in freshwater and salt water is rapidly developing over the world. In the developing countries, fishes are being raised as food. In many countries fish farming is a very important economic activity. The most recent branch, mariculture, has shown advances in raising fishes in brackish, estuarine and bay waters, in which marine, anadromous and catadromous fishes have successfully been grown and maintained

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

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