Putting T cells to sleep: a new paradigm for immune evasion by persistent viruses

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REDUCING COST OF POWER CONSUMPTION USING GOAL PROGRAMMING OPTIMIZATION AND RENEWABLE ENERGY SOURCE

The demand of cloud computing grows rapidly with the rapid increase in IT infrastructure. Cloud computing now a day, are widely used by industry, organization and society to deliver IT services. This rapid growth leads to the creation of large data centers. These data centers requires enormous amount of electrical power for its operation and thus, result in high operational cost and carbon-dioxide emission. In this work the key idea is to reduce the requirement of power consumption by efficient task allocation and its cost. Datacenters are connected to conventional power grid as well as to renewable energy source. We performed this work in two phases: first used goal programming optimization for energy efficient task allocation to reduce power consumption and then analyzed the reduction in cost if we use RES for power supply. We used solar power panel as renewable energy source and analyzed the significant reduction in cost

Optimization of Different Objective Function in Risk Assessment System

This paper proposes a new definition and conceptual framework for Risk assessment system. Risk assessment is the first process in the risk management methodology Organizations use risk system to determine the extent of the potential threat and the risk associated with an IT system throughout its SDLC. The output of this process helps to identify appropriate controls for eliminating risk and to determine the likelihood of a future adverse event. In this paper we will also discuss the Quantitative versus Qualitative Assessment, their advantage and disadvantages, while conducting the impact analysis. Once all the objective function have be optimized and completed, the results should be documented in an official report. This expanded view of Risk assessment emphasis the double role of risk management instruments, protecting basic livelihood as well as promoting risk taking and protecting basic livelihood. Keywords - Risk assessment, Risk Management, SDLC (System Development life cycle optimization

Herbal Remedies Used in the Treatment of Scorpion Sting and Snake Bite from the Malwa Region of Madhya Pradesh, India

Traditional medicine has a long history of serving people all over the world. Medicinal plants are an important element of indigenous medical systems in India as well as elsewhere. The enthnobotany and ubiquitous plants provide a rich resource for natural drug research and development. In recent years, the use of traditional medicine information on plant research has again received considerable interest. The circumstances under which the people lived- object poverty, disease and hunger combined with their curiosity towards their closed neighbour, the forest in which they lived and sought help in mitigating their woves and sorrows, must have been the essential factor in preserving their knowledge of herbs and usefulness to mankind. The present paper deals with the survey of 8 medicinal plant used in scorpion sting and snake bite by the aboriginal, tribal and non-tribal people of the Malwa region of India

Thyroid abnormality in abnormal uterine bleeding: an observational study from Medical College in Western UP, India

Background: Abnormal Uterine Bleeding (AUB) is one of the commonest gynecological complain in reproductive age group. Menstrual abnormalities are commonly seen when there is any alteration in thyroid function. Objective of present study was to investigate the prevalence of AUB and to determine the menstrual pattern in cases with thyroid dysfunction.Methods: The present cross sectional observational study was conducted Teerthankar Mahaveer Medical College and Research Center Moradabad. Total 400 cases presenting with AUB were included in the study. Routine blood test, ultrasonography and thyroid function tests were done in these cases.Results: Among all the cases presenting with menstrual abnormalities 26% had hypothyroidism and 9% have hyperthyroidism and rest had euthyroid status. Menorrhagia (45.2%) and polymenorrhoea (37.5%) were commonest menstrual abnormality seen in cases with hypothyroidism. Most cases with hyperthyroidism presented with hypomenorrhoea (27.8%).Conclusions: Thyroid function abnormality is common in cases presenting with AUB and it gets relieved in correcting hormonal imbalance

Assessment of the safety and efficacy of intravenous versus topical tranexamic acid in patients undergoing primary total hip and knee arthroplasty surgeries with respect to decreasing peri-operative blood loss and blood transfusion rates: a prospective and comparative study

Background: Synthetic antifibrinolytic agent like tranexamic acid has been increasingly used in Arthroplasty surgeries to decrease the peri-operative blood loss. The current study was undertaken to compare the efficacy between the intravenous and Topical route of TXA in deceasing the blood loss and transfusion rate in patients undergoing primary total hip and knee arthroplasty (THR and TKR) surgeries. Methods: A total of 120 patients were enrolled in the study with 60 each undergoing THR and TKR surgeries with 30 each given TXA in IV and Topical routes. Outcomes were assessed in terms of mean 24 hours drain output, mean blood loss, mean drop in hemoglobin blood transfusion rate. Results: The mean drain output was more in the IV group in both THR and TKR patients (p>0.05). The mean blood loss was more in the Topical group in both THR and TKR patients (p>0.05). The mean drop in hemoglobin was more in the Topical group, with the difference being significant in the THR patients (p<0.05) and being insignificant in TKR patients (p>0.05). In IV group 9 patients (15%) and in Topical group 25 patients (41.67%) needed blood transfusions, the difference being statistically significant. Conclusions: Both IV and Topical routes of TXA are equally effective in decreasing the peri-operative blood loss and transfusion rates in patients undergoing primary arthroplasty surgeries, with IV route having slightly upper hand as compared to the Topical route.

Exploring the Human Microbiome: The Potential Future Role of Next-Generation Sequencing in Disease Diagnosis and Treatment

The interaction between the human microbiome and immune system has an effect on several human metabolic functions and impacts our well-being. Additionally, the interaction between humans and microbes can also play a key role in determining the wellness or disease status of the human body. Dysbiosis is related to a plethora of diseases, including skin, inflammatory, metabolic, and neurological disorders. A better understanding of the host-microbe interaction is essential for determining the diagnosis and appropriate treatment of these ailments. The significance of the microbiome on host health has led to the emergence of new therapeutic approaches focused on the prescribed manipulation of the host microbiome, either by removing harmful taxa or reinstating missing beneficial taxa and the functional roles they perform. Culturing large numbers of microbial taxa in the laboratory is problematic at best, if not impossible. Consequently, this makes it very difficult to comprehensively catalog the individual members comprising a specific microbiome, as well as understanding how microbial communities function and influence host-pathogen interactions. Recent advances in sequencing technologies and computational tools have allowed an increasing number of metagenomic studies to be performed. These studies have provided key insights into the human microbiome and a host of other microbial communities in other environments. In the present review, the role of the microbiome as a therapeutic agent and its significance in human health and disease is discussed. Advances in high-throughput sequencing technologies for surveying host-microbe interactions are also discussed. Additionally, the correlation between the composition of the microbiome and infectious diseases as described in previously reported studies is covered as well. Lastly, recent advances in state-of-the-art bioinformatics software, workflows, and applications for analysing metagenomic data are summarized

Development and Evaluation of Active Case Detection Methods to Support Visceral Leishmaniasis Elimination in India.

As India moves toward the elimination of visceral leishmaniasis (VL) as a public health problem, comprehensive timely case detection has become increasingly important, in order to reduce the period of infectivity and control outbreaks. During the 2000s, localized research studies suggested that a large percentage of VL cases were never reported in government data. However, assessments conducted from 2013 to 2015 indicated that 85% or more of confirmed cases were eventually captured and reported in surveillance data, albeit with significant delays before diagnosis. Based on methods developed during these assessments, the CARE India team evolved new strategies for active case detection (ACD), applicable at large scale while being sufficiently effective in reducing time to diagnosis. Active case searches are triggered by the report of a confirmed VL case, and comprise two major search mechanisms: 1) case identification based on the index case's knowledge of other known VL cases and searches in nearby houses (snowballing); and 2) sustained contact over time with a range of private providers, both formal and informal. Simultaneously, house-to-house searches were conducted in 142 villages of 47 blocks during this period. We analyzed data from 5030 VL patients reported in Bihar from January 2018 through July 2019. Of these 3033 were detected passively and 1997 via ACD (15 (0.8%) via house-to-house and 1982 (99.2%) by light touch ACD methods). We constructed multinomial logistic regression models comparing time intervals to diagnosis (30-59, 60-89 and ≥90 days with =90 days compared to the referent of <30 days for ACD vs PCD were 0.88, 0.56 and 0.42 respectively. These ACD strategies not only reduce time to diagnosis, and thus risk of transmission, but also ensure that there is a double check on the proportion of cases actually getting captured. Such a process can supplement passive case detection efforts that must go on, possibly perpetually, even after elimination as a public health problem is achieved

Web Engineering Security: Essential Elements

Abstract Web Engineering has become one of the core disciplines for building Web-oriented applications. This paper proposes to reposition Web engineering to be more specific to what the Web is, by which we mean not only an interface technology, but an information system, into which Web-oriented applications have to be embedded. More traditional Web applications often are just user interfaces to data silos, whereas the last years have shown that welldesigned Web-oriented applications can essentially start with no data, and derive all their value from being open and attracting users on a large scale. The paper reaches a conclusion that Web Engineering at this stage is a moving target since Web technologies are constantly evolving, making new types of applications possible, which in turn may require innovations in how they are built, deployed and maintained