Negative Emotions in Fieldwork: A Narrative Inquiry of Three EFL Researchers’ Lived Experiences

Through narrative inquiry this research depicts and interprets the negative emotions that three English as Foreign Language (EFL) researchers experienced in different research sites during their fieldwork. Narrative inquiry informs the design of this investigation as the approach is particularly useful for understanding lived experiences. The study draws on autobiographical as well as narrative data to report the negative emotions that evolve during English language education fieldwork, an aspect absent in the existing literature. Findings suggest that the researchers experienced a wide range of negative emotions namely ethical dilemma, anger, anxiety, guilt, and shame. These results carry implications for language education research methodology, teaching, and fieldwork related ethical requirements of Institutional Review Board (IRB), and language education researchers’ necessary psychological support

Secure Physical Design

An integrated circuit is subject to a number of attacks including information leakage, side-channel attacks, fault-injection, malicious change, reverse engineering, and piracy. Majority of these attacks take advantage of physical placement and routing of cells and interconnects. Several measures have already been proposed to deal with security issues of the high level functional design and logic synthesis. However, to ensure end-to-end trustworthy IC design flow, it is necessary to have security sign-off during physical design flow. This paper presents a secure physical design roadmap to enable end-to-end trustworthy IC design flow. The paper also discusses utilization of AI/ML to establish security at the layout level. Major research challenges in obtaining a secure physical design are also discussed

Nanogels Based Drug Delivery System: A Promising Therapeutic Strategy

<p>Through particular structural designs and unique preparation techniques, nanogels can encapsulate drugs within three-dimensional crosslinked polymeric networks. This allows for the controlled and sustained delivery of loaded drugs, improving patient compliance and therapeutic efficacy. Furthermore, compared to other nanocarriers, nanogels offer a better drug loading capacity and biocompatibility. The science of therapeutic biology has undergone a revolution with the use of nanoparticles in drug delivery. Drug nanocarriers are being used to extend the drug's circulation time, regulate its release and stability, and shield it from cell clearance or premature breakdown in order to increase medicinal efficacy. For more secure and reliable delivery to the intended locations, the hydrogel nanoparticle dispersions are crosslinked using a crosslinked polymeric framework. The last two decades have seen the development of nanogels as promising biomaterials with a broad range of uses. Drug accumulation in disease areas can be improved and active targeting can be accomplished with the modification of nanogels. They can be made to respond to both internal and external stimuli, including pH, temperature, light, and redox, allowing the loaded medicine to release gradually. On the other hand, there has been new research on the use of nanogels for purposes unrelated to biomedicine. Since nanogels can be used for a wide range of purposes, we have thoroughly examined the state of the art for all practical uses and production techniques of nanogels. The purpose of this note is to understand why and how nanogels are regarded as such a novel approach to drugs delivery.</p&gt

Multi-scaling analysis of turbulent boundary layers over an isothermally heated flat plate with zero pressure gradient

A meticulous investigation into turbulent boundary layers over an isothermally heated flat plate with zero pressure gradient has been conducted. Eight distinct turbulence models, including algebraic yPlus, standard k-ω, standard k-ε, length-velocity, Spalart-Allmaras, low Reynolds number k-ε, shear stress transport, and v2-f turbulence models, are carefully chosen for numerical simulation alongside thermal energy and Reynolds-Averaged Navier-Stokes equations. A comparative analysis has determined that the Spalart-Allmaras model exhibits remarkable agreement with the results from direct numerical simulation, making it a reliable tool for predicting turbulent heat transfer and fluid flow, particularly at higher Prandtl and Reynolds numbers. Subsequently, a multi-scale investigation employs a comprehensive four-layer structure scheme and encompasses various momentum thickness Reynolds numbers of 1432, 2522, and 4000, and Prandtl numbers of 0.71, 2, and 5. The subsequent investigation reveals the governing non-dimensional numbers' substantial impact on the distribution and magnitude of mean thermal and flow characteristics. Notably, the scaling of mean thermal and momentum fields discloses the existence of a meso or intermediate layer characterized by a logarithmic nature unique to itself. The multi-scaling analysis of the flow field demonstrates greater conformity with the selected scaling variables primarily relying on the Reynolds number. Furthermore, the scaling of the energy field yields compelling outcomes within the inner and intermediate layers. However, according to the four-layer theory, minor discrepancies are observed in the outer layer when using the current scaling

Older adults with non-communicable chronic conditions and their health care access amid COVID-19 pandemic in Bangladesh:Findings from a cross-sectional study

BackgroundBurgeoning burden of non-communicable disease among older adults is one of the emerging public health problems. In the COVID-19 pandemic, health services in low- and middle-income countries, including Bangladesh, have been disrupted. This may have posed challenges for older adults with non-communicable chronic conditions in accessing essential health care services in the current pandemic. The present study aimed at exploring the challenges experienced by older Bangladeshi adults with non-communicable chronic conditions in receiving regular health care services during the COVID-19 pandemic.Materials and methodsThe study followed a cross-sectional design and was conducted among 1032 Bangladeshi older adults aged 60 years and above during October 2020 through telephone interviews. Self-reported information on nine non-communicable chronic conditions (osteoarthritis, hypertension, heart disease, stroke, hypercholesterolemia, diabetes, chronic respiratory diseases, chronic kidney disease, cancer) was collected. Participants were asked if they faced any difficulties in accessing medicine and receiving routine medical care for their medical conditions during the COVID-19 pandemic. The association between non-communicable chronic conditions and accessing medication and health care was analysed using binary logic regression model.ResultsMost of the participants aged 60-69 years (77.8%), male (65.5%), married (81.4%), had no formal schooling (58.3%) and resided in rural areas (73.9%). Although more than half of the participants (58.9%) reported having a single condition, nearly one-quarter (22.9%) had multimorbidity. About a quarter of the participants reported difficulties accessing medicine (23%) and receiving routine medical care (27%) during the pandemic, and this was significantly higher among those suffering from multimorbidity. In the adjusted analyses, participants with at least one condition (AOR: 1.95, 95% CI: 1.33-2.85) and with multimorbidity (AOR: 4.75, 95% CI: 3.17-7.10) had a higher likelihood of experiencing difficulties accessing medicine. Similarly, participants with at least one condition (AOR: 3.08, 95% CI: 2.11-4.89) and with multimorbidity (AOR: 6.34, 95% CI: 4.03-9.05) were significantly more likely to face difficulties receiving routine medical care during the COVID-19 pandemic.ConclusionsOur study found that a sizeable proportion of the older adults had difficulties in accessing medicine and receiving routine medical care during the pandemic. The study findings highlight the need to develop an appropriate health care delivery pathway and strategies to maintain essential health services during any emergencies and beyond. We also argue the need to prioritise the health of older adults with non-communicable chronic conditions in the centre of any emergency response plan and policies of Bangladesh

A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells

Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations, activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation, survival, and apoptosis. When compared to normal cells, cancer cells have higher levels of ROS, and they are responsible for the maintenance of the cancer phenotype; this unique feature in cancer cells may, therefore, be exploited for targeted therapy. Quercetin (QC), a plant-derived bioflavonoid, is known for its ROS scavenging properties and was recently discovered to have various antitumor properties in a variety of solid tumors. Adaptive stress responses may be induced by persistent ROS stress, allowing cancer cells to survive with high levels of ROS while maintaining cellular viability. However, large amounts of ROS make cancer cells extremely susceptible to quercetin, one of the most available dietary flavonoids. Because of the molecular and metabolic distinctions between malignant and normal cells, targeting ROS metabolism might help overcome medication resistance and achieve therapeutic selectivity while having little or no effect on normal cells. The powerful bioactivity and modulatory role of quercetin has prompted extensive research into the chemical, which has identified a number of pathways that potentially work together to prevent cancer, alongside, QC has a great number of evidences to use as a therapeutic agent in cancer stem cells. This current study has broadly demonstrated the function-mechanistic relationship of quercetin and how it regulates ROS generation to kill cancer and cancer stem cells. Here, we have revealed the regulation and production of ROS in normal cells and cancer cells with a certain signaling mechanism. We demonstrated the specific molecular mechanisms of quercetin including MAPK/ERK1/2, p53, JAK/STAT and TRAIL, AMPKα1/ASK1/p38, RAGE/PI3K/AKT/mTOR axis, HMGB1 and NF-κB, Nrf2-induced signaling pathways and certain cell cycle arrest in cancer cell death, and how they regulate the specific cancer signaling pathways as long-searched cancer therapeutics

Promotion of livelihood opportunities to address food insecurity in Rohingya refugee camps of Bangladesh

ABSTRACTThe world is facing a tremendous problem in the form of food insecurity that is posing a great challenge to achieving sustainable development goal 2 of creating a hunger-free world. Refugees and displaced populations are particularly vulnerable to food insecurity and malnutrition, who lack any productive assets and depend on aid. Rohingya refugees, displaced from Myanmar and took refuge in Cox’s Bazar, Bangladesh, live in a crowded unhealthy environment and are severely vulnerable to food insecurity and malnutrition. In our recent study, we found that only 21.6% of the households in Rohingya refugee camps had acceptable food security status. Interestingly, this study further revealed that acceptable food security status was significantly higher among the households that had some additional income aside from aid, compared to those relying on aid alone. This shows the importance of promoting livelihood opportunities to improve food security status among the camp dwellers. In this paper, we presented our views on promoting livelihood opportunities to address the overwhelming food insecurity crisis among the Rohingya refugees in Bangladesh

Integration of Rice Husk Ash as Supplementary Cementitious Material in the Production of Sustainable High-Strength Concrete

The incorporation of waste materials generated in many industries has been actively advocated for in the construction industry, since they have the capacity to lessen the pollution on dumpsites, mitigate environmental resource consumption, and establish a sustainable environment. This research has been conducted to determine the influence of different rice husk ash (RHA) concentrations on the fresh and mechanical properties of high-strength concrete. RHA was employed to partially replace the cement at 5%, 10%, 15%, and 20% by weight. Fresh properties, such as slump, compacting factor, density, and surface absorption, were determined. In contrast, its mechanical properties, such as compressive strength, splitting tensile strength and flexural strength, were assessed after 7, 28, and 60 days. In addition, the microstructural evaluation, initial surface absorption test, = environmental impact, and cost–benefit analysis were evaluated. The results show that the incorporation of RHA reduces the workability of fresh mixes, while enhancing their compressive, splitting, and flexural strength up to 7.16%, 7.03%, and 3.82%, respectively. Moreover, incorporating 10% of RHA provides the highest compressive strength, splitting tensile, and flexural strength, with an improved initial surface absorption and microstructural evaluation and greater eco-strength efficiencies. Finally, a relatively lower CO2-eq (equivalent to kg CO2) per MPa for RHA concrete indicates the significant positive impact due to the reduced Global Warming Potential (GWP). Thus, the current findings demonstrated that RHA can be used in the concrete industry as a possible revenue source for developing sustainable concretes with high performance