Lifshitz spacetimes, solitons, and generalized BTZ black holes in quantum gravity at a Lifshitz point

In this paper, we study static vacuum solutions of quantum gravity at a fixed Lifshitz point in (2+1) dimensions, and present all the diagonal solutions in closed forms in the infrared limit. The exact solutions represent spacetimes with very rich structures: they can represent generalized BTZ black holes, Lifshitz space-times or Lifshitz solitons, in which the spacetimes are free of any kind of space-time singularities, depending on the choices of the free parameters of the solutions. We also find several classes of exact static non-diagonal solutions, which represent similar space-time structures as those given in the diagonal case. The relevance of these solutions to the non-relativistic Lifshitz-type gauge/gravity duality is discussed.Comment: revtex4, 5 figures. Typos are correcte

Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C.

VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that contains a large extracellular N terminus with 35 calcium-binding domains. A truncating mutation in the Mass1 gene causes autosomal recessive, sound-induced seizures in the Frings mouse. However, the function of MASS1 and the mechanism underlying Frings mouse epilepsy are not known. Here, we found that MASS1 protein is enriched in the myelinated regions of the superior and inferior colliculi, critical areas for the initiation and propagation of audiogenic seizures. Using a panel of myelin antibodies, we discovered that myelin-associated glycoprotein (MAG) expression is dramatically decreased in Frings mice. MASS1 inhibits the ubiquitylation of MAG, thus enhancing the stability of this protein, and the calcium-binding domains of MASS1 are essential for this regulation. Furthermore, MASS1 interacts with Gαs/Gαq and activates PKA and PKC in response to extracellular calcium. Suppression of signaling by MASS1 RNAi or a specific inhibitor abrogates MAG up-regulation. We postulate that MASS1 senses extracellular calcium and activates cytosolic PKA/PKC pathways to regulate myelination by means of MAG protein stability in myelin-forming cells of the auditory pathway. Further work is required to determine whether MAG dysregulation is a cause or consequence of audiogenic epilepsy and whether there are other pathways regulated by MASS1

Time-frequency feature extraction from multiple impulse source signal of reciprocating compressor based on local frequency

Vibration signals generated by reciprocating compressor present a multiple impulse source property, which is typical non-stationary. For this kind of signal, time-frequency analysis techniques, such as STFT, WVT, WT and HHT, represent some limitations. To alleviate this problem, a novel concept of local frequency (LF) is proposed in the paper. Based on the concept, a time-frequency distribution algorithm is established. Some non-stationary simulation signals, including multi-harmonic signal, FM signal and multiple impulse source signal, are investigated to identify the feasibility and effectiveness of the novel time-frequency analysis technique. Compared with WVT, WT and HHT, time-frequency analysis based on LF represents a higher resolution and more useful information. Moreover, the proposed approach is applied to the fault feature extraction of reciprocating compressor gas valve vibration signal in normal valve state and gap valve state. The results indicate the superiority of proposed approach in extracting time-frequency features from multiple impulse source signal of reciprocating compressor, which obtains a more precise result than WVT, WT and HHT. So it can provide an effective basis to fault diagnosis of reciprocating compressor

MicroRNA-23a promotes myelination in the central nervous system.

Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment. Overexpression of lamin B1 leads to leukodystrophy characterized by demyelination of the central nervous system, and microRNA-23 (miR-23) was found to suppress lamin B1 and enhance oligodendrocyte differentiation in vitro. Here, we demonstrated that miR-23a-overexpressing mice have increased myelin thickness, providing in vivo evidence that miR-23a enhances both oligodendrocyte differentiation and myelin synthesis. Using this mouse model, we explored possible miR-23a targets and revealed that the phosphatase and tensin homologue/phosphatidylinositol trisphosphate kinase/Akt/mammalian target of rapamycin pathway is modulated by miR-23a. Additionally, a long noncoding RNA, 2700046G09Rik, was identified as a miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dependent manner. The data presented here imply a unique role for miR-23a in the coordination of proteins and noncoding RNAs in generating and maintaining healthy myelin

4,5,6,7-Tetra­chloro-N-(2-fluoro­phen­yl)phthalimide

In the title compound, C14H4Cl4FNO2, the benzene ring and the phthalimide plane are nearly planar, the maximum deviations being 0.005 (2) and 0.010 (2) Å, respectively, but the mol­ecule as a whole is not planar: the dihedral angle between the two planar ring systems is 68.06 (10)°. A short Cl⋯O contact of 2.914 (2) Å exists in the crystal structure