Quantum Hall Effects in a Non-Abelian Honeycomb Lattice

We study the tunable quantum Hall effects in a non-Abelian honeycomb optical lattice which is a many-Dirac-points system. We find that the quantum Hall effects present different features as change as relative strengths of several perturbations. Namely, a gauge-field-dressed next-nearest-neighbor hopping can induce the quantum spin Hall effect and a Zeeman field can induce a so-called quantum anomalous valley Hall effect which includes two copies of quantum Hall states with opposite Chern numbers and counter-propagating edge states. Our study extends the borders of the field of quantum Hall effects in honeycomb optical lattice when the internal valley degrees of freedom enlarge.Comment: 7 pages, 6 figure

Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.

BACKGROUND: Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines in TBEV-mediated neurological disease are poorly understood. METHODS: BALB/c mice were intracerebrally injected with TBEV, followed by evaluation of chemokine and cytokine profiles using protein array analysis. The virus-infected mice were treated with the CC chemokine antagonist Met-RANTES or anti-RANTES mAb to determine the role of RANTES in affecting TBEV-induced neurological disease. The underlying signaling mechanisms were delineated using RANTES promoter luciferase reporter assay, siRNA-mediated knockdown, and pharmacological inhibitors in human brain-derived cell culture models. RESULTS: In a mouse model, pathological features including marked inflammatory cell infiltrates were observed in brain sections, which correlated with a robust up-regulation of RANTES within the brain but not in peripheral tissues and sera. Antagonizing RANTES within CNS extended the survival of mice and reduced accumulation of infiltrating cells in the brain after TBEV infection. Through in vitro studies, we show that virus infection up-regulated RANTES production at both mRNA and protein levels in human brain-derived cell lines and primary progenitor-derived astrocytes. Furthermore, IRF-3 pathway appeared to be essential for TBEV-induced RANTES production. Site mutation of an IRF-3-binding motif abrogated the RANTES promoter activity in virus-infected brain cells. Moreover, IRF-3 was activated upon TBEV infection as evidenced by phosphorylation of TBK1 and IRF-3, while blockade of IRF-3 activation drastically reduced virus-induced RANTES expression. CONCLUSIONS: Our findings together provide insights into the molecular mechanism underlying RANTES production induced by TBEV, highlighting its potential importance in the process of neuroinflammatory responses to TBEV infection

Improving Vision Transformers by Revisiting High-frequency Components

The transformer models have shown promising effectiveness in dealing with various vision tasks. However, compared with training Convolutional Neural Network (CNN) models, training Vision Transformer (ViT) models is more difficult and relies on the large-scale training set. To explain this observation we make a hypothesis that ViT models are less effective in capturing the high-frequency components of images than CNN models, and verify it by a frequency analysis. Inspired by this finding, we first investigate the effects of existing techniques for improving ViT models from a new frequency perspective, and find that the success of some techniques (e.g., RandAugment) can be attributed to the better usage of the high-frequency components. Then, to compensate for this insufficient ability of ViT models, we propose HAT, which directly augments high-frequency components of images via adversarial training. We show that HAT can consistently boost the performance of various ViT models (e.g., +1.2% for ViT-B, +0.5% for Swin-B), and especially enhance the advanced model VOLO-D5 to 87.3% that only uses ImageNet-1K data, and the superiority can also be maintained on out-of-distribution data and transferred to downstream tasks.Comment: 18 pages, 7 figure

Compatibility Issues With Irregular Current Injection Islanding Detection Methods in Multi-DG Units Equipped With Grid-Connected Transformers

Compatibility issues with irregular current injection islanding detection methods are actually the problem that some irregular currents at the same frequency injected into the same line may cancel each other out and then the islanding detection may be impaired, which have been discussed under direct couple conditions (i.e., conditions without grid-connected transformers) in the literature. This article analyzes the issues under the opposite conditions where distributed generation (DG) units are equipped with grid-connected transformers, and is aimed at finding a solution. The analysis derives the setting formulas of key parameters for both three-phase and single-phase DG units, and shows that considering fault tolerance and practicability, only specific frequencies can be used for irregular currents. The usable frequencies are different under different cases. These conclusions are different from those based on direct couple conditions. By summarizing the conclusions based on conditions with grid-connected transformers achieved in this article and those based on direct couple conditions in the literature, a complete solution to compatibility issues is obtained. The conclusions in this article have been verified by the experiments and simulations at the end of this article

Historical Review about Research on “Bonghan System” in China

The meridian-collateral theory is the theoretical basis of acupuncture-moxibustion therapy. Professor Bonghan Kim, a professor of the Pyongyang Medical University of the Democratic People’s Republic of Korea, claimed that he found the anatomical structure of meridian-collaterals, named Bonghan corpuscles (BHCs) and Bonghan ducts (BHDs) system or primo vascular system (PVS), in 1962. From 1963 to 1965, researchers from our institute conducted a series of comparative anatomical experiments, trying to reproduce the so-called BHC- and BHD-like structures in different strains of animals. In the present paper, the authors introduced their research findings about BHC- and BHD-like structures in the young rabbit’s umbilicus including its external appearance, ectoplasm and endoplasm, and about strip-like and node-like objects in the blood vessels and lymph vessels near the larger abdominal and cervical blood vessels and chromaffin tissue in the back wall of the rabbit’s abdominal cavity and between the bilateral kidneys. In spite of existence of the BHC- and BHD-like structures in the rabbit, there has been no proved evidence for their association with the meridian-collateral system described in acupuncture medicine. In the present historical review, the authors also make a discussion about the significance of those findings

MCP-1, ICAM-1 and VCAM-1 are present in early aneurysmal dilatation in experimental rats.

Recent studies have suggested that inflammation actively participates in ascending aortic aneurysm formation. The aim of the present study was to evaluate the expression changes of adhesion molecules and MMPs in an experimental model of ascending aortic aneurysm induced by ascending aorta banding in Wistar rats. Twelve rats developed aortic dilation after ascending aorta banding treatment, while nine normal animals underwent surgery without banding were used as controls. Light microscope and scanning electron microscope showed that the wall of the ascending aorta became disorganized as well as infiltration by inflammatory cells in aneurysmal rats. By using immunohistochemical techniques, a significant increase in the immunostaining of MCP-1 was observed in the aneurysmal wall as compared to the normal aortic wall. Under similar experimental conditions, we also found that the immunostaining of ICAM-1 and VCAM-1 was markedly increased in the aneurysmal wall. In addition, gelatin zymographic analysis showed that the expression and activities of MMP-2 and MMP-9 were remarkably enhanced in the ascending aorta of ascending aortic aneurysmal rats as compared to normal rats. These results demonstrate that MCP-1, ICAM-1 and VCAM-1 are involved in the pathogenesis of ascending aortic aneurysm and an increase in the immunostaining and activity of MMP-2 and MMP-9 may promote the progression of ascending aortic aneurysm

Epidemiological and virological characteristics of pandemic influenza A (H1N1) 2009 in school outbreaks in China

Background: During the 2009 pandemic influenza H1N1 (2009) virus (pH1N1) outbreak, school students were at an increased risk of infection by the pH1N1 virus. However, the estimation of the attack rate showed significant variability. Methods: Two school outbreaks were investigated in this study. A questionnaire was designed to collect information by interview. Throat samples were collected from all the subjects in this study 6 times and sero samples 3 times to confirm the infection and to determine viral shedding. Data analysis was performed using the software STATA 9.0. Findings: The attack rate of the pH1N1 outbreak was 58.3% for the primary school, and 52.9% for the middle school. The asymptomatic infection rates of the two schools were 35.8% and 37.6% respectively. Peak virus shedding occurred on the day of ARI symptoms onset, followed by a steady decrease over subsequent days (p = 0.026). No difference was found either in viral shedding or HI titer between the symptomatic and the asymptomatic infectious groups. Conclusions: School children were found to be at a high risk of infection by the novel virus. This may be because of a heightened risk of transmission owing to increased mixing at boarding school, or a lack of immunity owing to socioeconomic status. We conclude that asymptomatically infectious cases may play an important role in transmission of the pH1N1 virus

Dietary inclusion of fermented ginger straw effect on the growth performance, gastrointestinal tract development and caecal fermentation of fattening rabbits

[EN] This experiment was conducted to evaluate the effects of dietary inclusion of fermented ginger straw on the growth performance, gastrointestinal tract development and caecal fermentation of fattening rabbits. A total of 160 45-d-old Laiwu black rabbits were randomly divided into 4 groups and fed 0% (Control), 5, 10 or 15% fermented ginger straw in their diet as a replacement for peanut straw powder. The trial lasted for 7 d of adaptation and 43 d for testing. Growth performance was recorded from 52 to 95 d of age (n=5 per treatment with 30 rabbits, 3 males and 3 females per replicate), TTAD of nutrients from 91 to 95 d of age, and gastrointestinal tract development, caecum fermentation and carcass traits were determined at 95 d of age (n=5 per treatment with 10 rabbits, 1 males and 1 females in per replicate).The results showed that the average daily gain and final body weight in the experimental groups (5, 10 and 15% fermented ginger straw) were higher than in the control group (P<0.05). However, the average daily feed intake in the 15% group was higher than in the other groups, while the total tract apparent digestibility of crude protein, ether extract, neutral detergent fibre and acid detergent fibre were lower than in the control group (P<0.05), and the relative weights of the stomach, small intestine and caecum content in the 15% substitution group were higher than those in the control group (P<0.05). In addition, the thickness of the muscle layer in the 15% substitution group was higher than that in the other groups (P<0.05). Moreover, pH and total volatile fatty acids concentration in the caecal content were similar among the 4 groups (P>0.05). The current work shows that fermented ginger straw could be used as roughage material in fattening rabbit production up to a dietary dose of 10%.This study was supported by Earmarked Fund for Modern Agro-industry Technology Research System (CARS-43-G-7); Shandong Province Modern Agricultural Industry Technology System (SDAIT-21); Scientific and Technological Problems Project Unveiled by Shandong Academy of Agricultural Sciences (SHJB2021-43).Sun, HT.; Wang, Y.; Bai, LY.; Liu, C.; Xu, YH.; Gao, SX.; Jiang, WX.... (2022). Dietary inclusion of fermented ginger straw effect on the growth performance, gastrointestinal tract development and caecal fermentation of fattening rabbits. World Rabbit Science. 30(4):267-276. https://doi.org/10.4995/wrs.2022.1609326727630