Board 141: Engineering Identity as a Predictor of Undergraduate Students\u27 Persistence in Engineering

Improving graduation rates of students who have selected and been admitted to engineering majors is a pivotal strategy in supporting national initiatives to increase the number of engineering graduates. Research suggests that the degree to which a student is attached to or belongs to engineering as a discipline better explains persistence-related outcomes than lack of interest and ability. As a result, identity frameworks have proven useful for furthering the understanding of engineering persistence. In this paper, we examine the relationship between undergraduate students’ engineering identity and persistence as an engineering major. As part of an ongoing NSF IUSE project, a concise five-item measure of engineering identity was developed and validated. That measure was administered to a large sample of engineering freshmen at a southwestern engineering school. Engineering identity was assessed twice, once prior to the beginning of fall semester when students had not yet taken an engineering course (Time 1) and once at the end of fall semester after completing introductory engineering courses (Time 2). Persistence as an engineering major was assessed prior to the beginning of the sophomore year (Time 3). Results showed that engineering identity measured at both Time 1 (r = .09) and Time 2 (r = .22) was significantly related to persistence as an engineering major at Time 3. The paper describes the implications of these longitudinal findings, future data analyses, and the importance of engineering identity. Having a concise, validated measure of identity will be valuable for quick assessment of student engineering identity and gaining further understanding of the relationship between identity and persistence in engineering

A Cavalcade of Field Botanists in Oklahoma - Contributors to Our Knowledge of the Flora of Oklahoma

As members of the Oklahoma Native Plant Society (ONPS) well know, Oklahoma has a tremendous diversity of vascular plants—174 families, 854 genera, and approximately 2,600 species—that reflects the ecogeographic diversity present within the state’s borders (Tyrl et al. 2008). Our knowledge of this flora is the result of contributions by numerous individuals for more than 450 years. Some simply recorded their observations of the state’s flora as they passed through; whereas, others made systematic surveys and documented their work by actually collecting plants for voucher specimens to be deposited in herbaria. These individuals and the contributions that they have made to our knowledge of the plants and vegetation of Oklahoma are the subject of this essay. Its title and concept are rooted in a presidential address given by H.I. Featherly in 1942 to the Oklahoma Academy of Science and a master’s thesis by Wanona Henson, one of his graduate students (Henson 1941; Featherly 1943). We have unabashedly adopted their approach and excerpted some of their thoughts about the state’s first field botanists in our synopses. As they did, we present our individuals more or less chronologically. Each synopsis comprises a brief biographical sketch and the botanical contribution(s) they made. When specific plants are cited, currently accepted scientific names are used unless otherwise noted. Common names are taken from Taylor and Taylor (1994), Tyrl and coworkers (2008), Folley (2011), and USDA, NRCS (2013)

Selecting the Number and Labels of Topics in Topic Modeling: A Tutorial

13 pagesTopic modeling is a type of text analysis that identifies clusters of co-occurring words, or latent topics. A challenging step of topic modeling is determining the number of topics to extract. This tutorial describes tools researchers can use to identify the number and labels of topics in topic modeling. First, we outline the procedure for narrowing down a large range of models to a select number of candidate models. This procedure involves comparing the large set on fit metrics, including exclusivity, residuals, variational lower bound, and semantic coherence. Next, we describe the comparison of a small number of models using project goals as a guide and information about topic representative and solution congruence. Finally, we describe tools for labeling topics, including frequent and exclusive words, key examples, and correlations among topics

A Rodent Model for Dirofilaria Immitis, Canine Heartworm: Parasite Growth, Development, and Drug Sensitivity in NSG Mice

Heartworm disease, caused by Dirofilaria immitis, remains a significant threat to canines and felines. The development of parasites resistant to macrocyclic lactones (ML) has created a significant challenge to the control of the infection. The goal of this study was to determine if mice lacking a functional immune response would be susceptible to D. immitis. Immunodeficient NSG mice were susceptible to the infection, sustaining parasites for at least 15 weeks, with infective third-stage larvae molting and developing into the late fourth-stage larvae. Proteomic analysis of host responses to the infection revealed a complex pattern of changes after infection, with at least some of the responses directed at reducing immune control mechanisms that remain in NSG mice. NSG mice were infected with isolates of D. immitis that were either susceptible or resistant to MLs, as a population. The susceptible isolate was killed by ivermectin whereas the resistant isolate had improved survivability, while both isolates were affected by moxidectin. It was concluded that D. immitis survives in NSG mice for at least 15 weeks. NSG mice provide an ideal model for monitoring host responses to the infection and for testing parasites in vivo for susceptibility to direct chemotherapeutic activity of new agents

‘How can I be post-Soviet if I was never Soviet?’ Rethinking categories of time and social change – a perspective from Kulob, southern Tajikistan

Based on anthropological fieldwork conducted in the Kulob region of southern Tajikistan, this paper examines the extent to which the existing periodization ‘Soviet/post-Soviet’ is still valid to frame scholarly works concerning Central Asia. It does so through an analysis of ‘alternative temporalities’ conveyed by Kulob residents to the author. These alternative temporalities are fashioned in especially clear ways in a relationship to the physical transformations occurring to two types of housing, namely flats in building blocks and detached houses. Without arguing that the categories ‘Soviet’ and ‘post-Soviet’ have become futile, the author advocates that the uncritically use of Soviet/post-Soviet has the unwanted effect of shaping the Central Asian region as a temporalized and specialized ‘other’

Features of adenosine metabolism of mouse heart

Adenosine metabolism and transport were evaluated in the isolated perfused mouse heart and compared with the well-established model of isolated perfused guinea pig heart. Coronary venous release of adenosine under well-oxygenated conditions in the mouse exceeds that in the guinea pig threefold when related to tissue mass. Total myocardial adenosine production rate under this condition was approximately 2 nmol/min per gramme and similar in both species. Coronary resistance vessels of mice are highly sensitive to exogenous adenosine, and the threshold for adenosine-induced vasodilation is approximately 30 nmol/l. Adenosine membrane transport was largely insensitive to nitrobenzyl-thioinosine (NBTI) in mouse heart, which is in contrast to guinea pig and several other species. This indicates the dominance of NBTI-insensitive transporters in mouse heart. For future studies, the assessment of cytosolic and extracellular adenosine metabolism and its relationship with coronary flow will require the use of more effective membrane transport blockers

Chromosomal disorders:estimating baseline birth prevalence and pregnancy outcomes worldwide

Chromosomal disorders, of which Down syndrome is the most common, can cause multi-domain disability. In addition, compared to the general population, there is a higher frequency of death before the age of five. In many settings, large gaps in data availability have hampered policy-making, programme priorities and resource allocation for these important conditions. We have developed methods, which overcome this lack of data and allow estimation of the burden of affected pregnancies and their outcomes in different settings worldwide. For example, the methods include a simple equation relating the percentage of mothers 35 and over to Down syndrome birth prevalence. The results obtained provide a starting point for consideration of services that can be implemented for the care and prevention of these disorders

Internal migration and inclusive development: Insights from the field

Migration is a universal phenomenon. From time immemorial women and men have travelled in search of better living. There are two separate streams of migration. The first one is at the upper end of human capital hierarchy, to fill in existing surplus demand in the labour market of destination regions. Consequently, this process is highly selective in nature – in terms of skill & training, age, and gender. The second stream emerges due to ‘Push factors’ or distress conditions in the source regions (relative to the destination) – economic hardships in the form of low wages, high unemployment, heavy population pressure, etc. in the native places, and the lure of better earning opportunities in the economically vibrant destination region. This process is a coping mechanism of poor families and helps them come out of poverty. Thus migration can be both discriminatory and egalitarian. Another issue is the emerging pattern of identity and conflict between natives and migrants in several parts of the country. Social inclusion of migrants is sometimes at jeopardy and goes against the ethos and economics of one nation-one labour market principle. This issue needs to be examined also. Using field data, this paper seeks to understand the following issues:(a) Who migrates – what are the social, economic and institutional factors that determine migration decisions? (b) Are there any disparities between migrants/natives and various socio-religious groups regarding – Educational Attainment, Availability of employment, Nature of employment (casual/regular), Occupational distribution, and Earnings?; (c) What are the migration patterns of lagging socio-religious groups? Whether migration does form a route out of poverty for them, and whether specific policies for these groups exist or should be recommended; (d) Understand whether the process of migration is leading to better human capital standards for the subsequent generation or stifling it; and, (e) Examine the perception of natives in receiving regions about migrant workers and how migrants assimilate. The paper uses primary data from 3 districts of Bengal to explore the issues highlighted. It would also explore the impact on the migrants, the receiving regions and the sending regions through case studies to help us in understanding the issue of social inclusion of migrants. Several processes/local systems of migration have also been examined to highlight the vulnerability of the migrants. Inferences from the paper would help in devising a broadbased and inclusive migration policy

SOCS2-Induced Proteasome-Dependent TRAF6 Degradation: A Common Anti-Inflammatory Pathway for Control of Innate Immune Responses

Pattern recognition receptors and receptors for pro-inflammatory cytokines provide critical signals to drive the development of protective immunity to infection. Therefore, counter-regulatory pathways are required to ensure that overwhelming inflammation harm host tissues. Previously, we showed that lipoxins modulate immune response during infection, restraining inflammation during infectious diseases in an Aryl hydrocarbon receptor (AhR)/suppressors of cytokine signaling (SOCS)2-dependent-manner. Recently, Indoleamine-pyrrole 2,3- dioxygenase (IDO)-derived tryptophan metabolites, including L-kynurenine, were also shown to be involved in several counter-regulatory mechanisms. Herein, we addressed whether the intracellular molecular events induced by lipoxins mediating control of innate immune signaling are part of a common regulatory pathway also shared by L-kynurenine exposure. We demonstrate that Tumor necrosis factor receptor-associated factor (TRAF)6 – member of a family of adapter molecules that couple the TNF receptor and interleukin-1 receptor/Toll-like receptor families to intracellular signaling events essential for the development of immune responses – is targeted by both lipoxins and L-kynurenine via an AhR/SOCS2-dependent pathway. Furthermore, we show that LXA4- and L-kynurenine-induced AhR activation, its subsequent nuclear translocation, leading SOCS2 expression and TRAF6 Lys47-linked poly-ubiquitination and proteosome-mediated degradation of the adapter proteins. The in vitro consequences of such molecular interactions included inhibition of TLR- and cytokine receptor-driven signal transduction and cytokine production. Subsequently, in vivo proteosome inhibition led to unresponsiveness to lipoxins, as well as to uncontrolled pro-inflammatory reactions and elevated mortality during toxoplasmosis. In summary, our results establish proteasome degradation of TRAF6 as a key molecular target for the anti-inflammatory pathway triggered by lipoxins and L-kynurenine, critical counter-regulatory mediators in the innate and adaptive immune systems