Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS

Background: Patients with irritable bowel syndrome with diarrhoea (IBS-D) experience restriction in daily activities and decreased health-related quality of life (QOL). Aim To investigate effects of alosetron on patient-reported health-related QOL, satisfaction and productivity in women with severe IBS-D. Methods: A total of 705 women (severe IBS-D, Rome II criteria) randomised to alosetron 0.5 mg QD, 1 mg QD, 1 mg BID, or placebo for 12 weeks were studied. IBSQOL, treatment satisfaction, daily activities, and lost workplace productivity (LWP) were evaluated at randomisation and Week 12. Results: One or more doses of alosetron significantly improved all IBSQOL domains except for sexual function from baseline vs. placebo. The magnitude of IBSQOL changes was consistent with a clinically meaningful effect. Alosetron 0.5 mg QD and 1 mg BID significantly reduced IBS interference with social/leisure activities and LWP from baseline vs. placebo [social/leisure (mean ±S.E.) days lost: −6.7 ± 0.8, −7.0 ± 0.9, P < 0.01; LWP (mean ± S.E.) h lost: −11.0 ± 3.3, −21.1 ± 4.1, P < 0.05 respectively]. Significantly more patients treated with alosetron reported satisfaction vs. placebo. Improvements in IBSQOL, LWP, and treatment satisfaction significantly correlated with global improvement of IBS symptoms. The incidence of adverse events with alosetron was low with constipation being the most commonly reported event. A single case of ischaemic colitis occurred, in a patient receiving alosetron 0.5 mg QD. Conclusions: In women with severe IBS-D, alosetron treatment, including 0.5 mg QD, resulted in statistically significant and clinically relevant improvements in health-related QOL, restriction of daily activities and treatment satisfaction over placebo. IBS symptom improvement corresponded with positive changes in IBSQOL, LWP and treatment satisfaction

The Afterlives of Frantz Fanon and the Reconstruction of Postcolonial Studies

This essay mobilizes Fanon as a point of entry into mapping the current state of postcolonial studies, and within that, reflects on what constitutes the postcolonial canon. Over a gradual course of the eighties and nineties, there has come about a transition from the field’s founding moments in which anti-imperialism, tricontinentalism, Third World nationalism and aesthetics of realism and resistance thrived, to the current trends that show a slant toward postmodernist fragmentation, multiculturalism, issues of diaspora, metropolitan narratives as well as a proclivity toward theorizing the field itself. There are many reasons for this: the specific dynamics of the post-Cold War American culture within which these works were received; the compromised relationship between academic and commercial publishing culture, which made a jump from narratives of decolonization and neocolonialism to metropolitan multiculturalism; and the sway of postmodernism over academia as a whole, which led to a disregard for Marxist theories and, more importantly, to a neglect of realism as a mode and aesthetic in postcolonial theory. These factors have worked together to shape how the genealogy of postcolonial studies and its theory have come to be accepted as “obvious.” This has, in turn, had strong repercussions for the kind of literature and theory that have come to be celebrated and canonized within the field. The essay draws on Anthony Alessandrini's Frantz Fanon and the Future of Cultural Politics: Finding Something Different (2014) and Neil Lazarus' The Postcolonial Unconscious (2011) to offer a reconstructed genealogy of the field of postcolonial studies.

The study of a model for via transition and the multi-layer via transition tool GUI design

One of the many challenges faced by engineers working with the present design scenario is to estimate the extent to which a signal, with significant high frequency content, is affected when it is routed on a printed circuit board. The printed circuit board routing will include the transition through the geometries like micro-strip or strip-line transmission lines, via transitions, and irregularities or asymmetries in the aforementioned geometries. One of these discontinuities, the via transition, results in the interaction of the signal on the via and the cavity (plane-pair) through which it passes. The via transition modeling will help characterize a block in the signal path. Section 1 explains the cavity model, and derives an expression for the impedance at a port in a rectangular cavity. The via to cavity connection, and the via capacitance calculation is explained. Then, five practical examples are used to show the model assembly in a circuit fashion, and the results are compared to the measurements. This modeling approach has been automated and integrated into the Multilayer Via Transition Tool, a tool that models all the common PCB geometries and provides the results as network parameters for the user defined ports. This tool is used for performance analysis and design optimization for the high speed PCBs. The tool includes a basic graphic user interface and an engine. Section 2 explains the design methodology for the provided graphic user interface. It explains interface design from the basic set of user inputs required by the engine to run. This section also talks about the difficulties in implementing the interface, and the required improvements for a professional tool --Abstract, page iii

Continuing mortality of vultures in India associated with illegal veterinary use of diclofenac and a potential threat from nimesulide

AbstractThe collapse of South Asia's Gyps vulture populations is attributable to the veterinary use of the non-steroidal anti-inflammatory drug (NSAID) diclofenac. Vultures died after feeding on carcasses of recently-medicated animals. The governments of India, Nepal and Pakistan banned the veterinary use of diclofenac in 2006. We analysed results of 62 necropsies and 48 NSAID assays of liver and/or kidney for vultures of five species found dead in India between 2000 and 2012. Visceral gout and diclofenac were detected in vultures from nine states and three species: Gyps bengalensis, Gyps indicus and Gyps himalayensis. Visceral gout was found in every vulture carcass in which a measurable level of diclofenac was detected. Meloxicam, an NSAID of low toxicity to vultures, was found in two vultures and nimesulide in five vultures. Nimesulide at elevated tissue concentrations was associated with visceral gout in four of these cases, always without diclofenac, suggesting that nimesulide may have similar toxic effects to those of diclofenac. Residues of meloxicam on its own were never associated with visceral gout. The proportion of Gyps vultures found dead in the wild in India with measurable levels of diclofenac in their tissues showed a modest and non-significant decline since the ban on the veterinary use of diclofenac. The prevalence of visceral gout declined less, probably because some cases of visceral gout from 2008 onwards were associated with nimesulide rather than diclofenac. Veterinary use of nimesulide is a potential threat to the recovery of vulture populations.Financial support and assistance for the project from the Director, Indian Veterinary Research Institute (IVRI), the UK Government’s Darwin Initiative and the Royal Society for the Protection of Birds is gratefully acknowledged.This is the accepted manuscript. The final version is available from Cambridge University Press via http://dx.doi.org/10.1017/S003060531500037

Printed circuit board power distribution network modeling, analysis and design, and, statistical crosstalk analysis for high speed digital links

High-speed digital systems are moving to higher data rates and smaller supply voltages as the scale of integration goes smaller. With the smaller bit periods and the smaller operating voltages, the tolerable timing and noise margins are reducing. There are many sources of disturbances contributing to the tolerance margins. These margins have to account for inter symbol interference (ISI), reflections, jitter, noise from power distribution networks (PDN) and crosstalk. An important task during the design phase of the system is to find and mitigate the noise from such sources. This thesis proposes modeling and analysis methodology to resolve some of the problems while proposing relevant design methodologies to reduce the system design cycles. PDN design forms a critical part of a high-speed digital design to provide a low-noise power supply to the integrated circuits (ICs) within some peak voltage ripple for normal functioning. Switching of transistors in the IC leads to a high-frequency current draw and generates the simultaneous switching noise (SSN), which propagates along the PDN from the chip to the PCB and causes several EMI and SI problems. A physics-based modeling approach for PCB PDN is proposed which is used for analysis and design guideline development. A design methodology is developed which guides the designer to make better design decisions, knowing the impact on PDN performance without the use of full-wave tools. Crosstalk forms a critical part of the budget, and if ignored, can lead to design failures. A statistical method to find the distribution of crosstalk at the victim using the single bit response principle is proposed. The methodology is extended to multiple-aggressor system, and, can be used to identify worst case crosstalk and find dominant crosstalk contributors in a system. --Abstract, page iii

Age, retirement and health as factors in volunteering in later life

Volunteering in later life attracts attention because its benefits older volunteers, voluntary associations, and society. Unfortunately, researchers and practitioners struggle with the complexity of predicting who volunteers. The authors ask whether a rough identification of older volunteers solely based on age is possible. The authors answer this question by means of structural equation modeling, analyzing international survey data. The findings show that the direct effect of age on the time older people spend volunteering is negligible. Moreover, the age patterns in volunteering created by retirement and declining health are weak. Those findings make age an unsuitable indicator for volunteering in later life. The authors recommend that voluntary organizations and policy makers use personal characteristics, such as health status, when defining their target groups for programs that encourage volunteering. In addition, researchers should not use an age group when referring to the third age, meaning the active and productive part of old age

Towards a universal criteria for turbulence suppression in dilute turbidity currents with non-cohesive sediments

Turbidity currents exhibit fascinating physics as their sustained propagation depends on a tight interplay between the suspended sediments and turbulence. If resuspension dominates over deposition the intensity of the flow will increase, while if deposition dominates the flow turbulence can be completely damped inducing rapid settling of sediments and, eventually, flow extinction. This work explores the phenomenon whereby turbulence in a dilute turbidity current with non-cohesive sediments is abruptly extinguished owing to increasedsuspended sediment stratification.  Three parameters control the flow dynamics: Reynolds number (Re_t), Richardson number (Ri_t) and sediment settling velocity (V_z). The condition for complete turbulence suppression can be expressed as a critical value for Ri_t V_z. Based on simulations, limited experiments and limited field data, the critical value appears to have a logarithmic dependence on Re_t.Fil: Cantero, Mariano Ignacio. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Shringarpure, Mrugesh. University of Florida; Estados UnidosFil: Balachandar, S.. University of Florida; Estados Unido

Direct N-body Kernels for Multicore Platforms

Abstract—We present an inter-architectural comparison of single- and double-precision direct n-body implementations on modern multicore platforms, including those based on the Intel Nehalem and AMD Barcelona systems, the Sony-Toshiba-IBM PowerXCell/8i processor, and NVIDIA Tesla C870 and C1060 GPU systems. We compare our implementations across platforms on a variety of proxy measures, including performance, coding complexity, and energy efficiency. I