Hybrid Cloud Workload Monitoring as a Service

Cloud computing and cloud-based hosting has become embedded in our daily lives. It is imperative for cloud providers to make sure all services used by both enterprises and consumers have high availability and elasticity to prevent any downtime, which impacts negatively for any business. To ensure cloud infrastructures are working reliably, cloud monitoring becomes an essential need for both businesses, the provider and the consumer. This thesis project reports on the need of efficient scalable monitoring, enumerating the necessary types of metrics of interest to be collected. Current understanding of various architectures designed to collect, store and process monitoring data to provide useful insight is surveyed. The pros and cons of each architecture and when such architecture should be used, based on deployment style and strategy, is also reported in the survey. Finally, the essential characteristics of a cloud monitoring system, primarily the features they host to operationalize an efficient monitoring framework, are provided as part of this review. While its apparent that embedded and decentralized architectures are the current favorite in the industry, service-oriented architectures are gaining traction. This project aims to build a light-weight, scalable, embedded monitoring tool which collects metrics at different layers of the cloud stack and aims at achieving correlation in resource-consumption between layers. Future research can be conducted on efficient machine learning models used on the monitoring data to predict resource usage spikes pre-emptively

Study of bit-patterned FePt media for high density magnetic recording

Ph.DDOCTOR OF PHILOSOPH

Knowledge and awareness about optometry profession among rural versus urban population in Eastern India: a survey-based study

Background: The main purpose of this study was to determine the awareness of optometry and to create awareness of optometry among rural and urban population of Kolkata.Methods: A cross-sectional descriptive study was conducted among rural and urban population. A total of 671 participants- male=378 and female=293, were enrolled in this study. An amplified self-structured questionnaire was used to collect data from the participants through a survey camp.Results: Out of 671 subjects, (328 rural and 343 urban subjects), 62 (18.9%) and 166 (48.3%) (95%, CI: 1.93-1.88) were know about optometry in rural and urban population respectively. 4.9% and 14% (95%, CI: 1.97-1.94) did knew the difference between optometrist and ophthalmologists, while in participants opinion optometrist is assistant of ophthalmologist was 3.4% and 1.5% (95%, CI: 2.69-2.61) in rural and urban participants respectively. However, 18.2% (rural) and 32% (urban) (95%, CI: 2.31-2.17) participants think that optometrist is trained in detection and recognition of eye diseases while 22.6% and 26.8% (95%, CI: 3.20-3.02) thinks they can prescribe spectacles and contact lens independently in rural and urban participants respectively. All factors mentioned were found to be statistically significant (p<0.05) with the Chi square and ANOVA test in SPSS version 21.Conclusions: These findings seem to indicate lack of awareness and knowledge about optometry profession. There is a need to increase campaign in these areas via educational programs, awareness survey camp, a poster explaining the eye care, social media regarding eye care provider’s duties and practices, exhibitions for public concerning the profession of optometry

Formulation Development to Enhance the Solubility of Metoclopramide Base Drug by Solid Dispersion and Evaluation of Transdermal Film

Aims &amp; Objectives: The present work deals with the modification of controlled release dosage form of poorly water soluble drug (Metoclopramide hydrochloride) in order to improve the bioavailability and to control drug release for a longer period of time by the aid of solid dispersion. Methods: Various binary combination of MET-solid dispersion was prepared with different carriers such as HPβCD, PVP K30 and PLX-188 by solvent evaporation technique and then the aqueous solubility, dissolution study and phase solubility study was performed. DSC analysis is performed to carry out for metoclopramide loaded solid dispersion, physical mixture &amp; also for pure drug to analyze the crystalline and amorphous nature of compounds. Results and Discussion:&nbsp; The saturation solubility of Metoclopramide with various carriers at different pH was performed and found that in pH 5.5 (solubility is 5553.2µg/ml), pH 6.8 (3363.3µ/ml), pH 7.4 (1367.3µg/ml) at 37oC. In dissolution study of solid dispersion (5:1) of different carriers in DDW, the Cumulative % dissolution is found in the order of PVP K30&gt;PLX-Met&gt;HPβCD-Met &amp; in pH 7.4, in the order of PLX-Met&gt;PVP K30&gt;HPβCD-Met. DSC thermogram of Metoclopramide base showed a sharp endothermic peak at its melting point (147oC) which exhibits in crystalline form complying with that of Metoclopramide hydrochloride form, melting point was found to be 850C.&nbsp; In the ex-vivo study of several transdermal patches, patch C [SD of MET: HPβCD (1:5)] showed the controlled release and permeation of drug. Conclusion: Poor solubility of new chemical entities being a well known problem for past few decades despite the imbalance between significant research efforts &amp; few successful marketed formulations, the solid dispersion proves to hold a key position among all the various formulation strategies to enhance the aqueous solubility &amp; dissolution rate and thereby the bioavailability of&nbsp; poorly aqueous solubility of drug. Keywords: Bioavailability,DSC, Metoclopramide hydrochloride, solid dispersion, HPβCD

Ovonic threshold-switching GexSey chalcogenide materials : stoichiometry, trap nature, and material relaxation from first principles

Density functional theory simulations are used to identify the structural factors that define the material properties of ovonic threshold switches (OTS). They show that the nature of mobility-gap trap states in amorphous Ge-rich Ge50Se50 is related to Ge-Ge bonds, whereas in Se-rich Ge30Se70 the Ge valence-alternating-pairs and Se lone-pairs dominate. To obtain a faithful description of the electronic structure and delocalization of states, it is required to combine hybrid exchange-correlation functionals with large unit-cell models. The extent of localization of electronic states depends on the applied external electric field. Hence, OTS materials undergo structural changes during electrical cycling of the device, with a decrease in the population of less exothermic Ge-Ge bonds in favor of more exothermic Ge-Se. This reduces the amount of charge traps, which translates into coordination changes, an increase in mobility-gap, and subsequently changes in the selector-device electrical parameters. The threshold voltage drift process can be explained by natural evolution of the nonpreferred Ge-Ge bonds (or "chains"/clusters thereof) in Ge-rich GexSe1-x. The effect of extrinsic doping is shown for Si and N, which introduce strong covalent bonds into the system, increase both mobility-gap and crystallization temperature, and decrease the leakage current

Two-step temperature deposited FePt bilayer for tunable magnetic properties

Tuning the magnetic properties of FePt media is of great interest in the bid to achieve high areal densities. In this work, we demonstrate that properties of FePt media can be tuned using a two-step temperature deposited FePt bilayer. In this bilayer scheme, the first layer of FePt was deposited at a high nominal temperature (600 °C), whilst the second layer was deposited at a lower temperature over the first layer. This resulted in tunable magnetic and improved topographical properties, and was due to the interplay of a number of temperature-dependent factors such as epitaxial growth, new grain nucleation, surface mobility, and difference in the thermal expansion coefficients. Transmission electron microscopy imaging was used to understand the growth dynamics of the second FePt layer in the two-step temperature deposited structures.Accepted versio

Probing the role of C+ ion energy, thickness and graded structure on the functional and microstructural characteristics of ultrathin carbon films (&lt;2 nm)

10.1016/j.triboint.2014.08.001Tribology International8173-8

A Systematic Assessment of W-Doped CoFeB Single Free Layers for Low Power STT-MRAM Applications

Spin-transfer torque magnetoresistive random access memory (STT-MRAM) technology is considered to be the most promising nonvolatile memory (NVM) solution for high-speed and low power applications. Dual MgO-based composite free layers (FL) have driven the development of STT-MRAMs over the past decade, achieving data retention of 10 years at the cost of higher write power consumption. In addition, the need for tunnel magnetoresistance (TMR)-based read schemes limits the flexibility in materials beyond the typical CoFeB/MgO interfaces. In this study, we propose a novel spacerless FL stack comprised of CoFeB alloyed with heavy metals such as tungsten (W) which allows effective modulation of the magnet properties (Ms, Hk) while retaining compatibility with MgO layers. The addition of W results favours a delayed crystallization process, in turn enabling higher thermal budgets up to 180 min at 400 °C. The presence of tungsten reduces the total FL magnetization (Ms) but simultaneously increasing its temperature dependence, thus, enabling a dynamic write current reduction of ~15% at 2 ns pulse widths. Reliable operation is demonstrated with a WER of 1 ppm and endurance &gt;1010 cycles. These results pave the way for alternative designs of STT-MRAMs for low power electronics

Unveiling the Interaction between Fatty-Acid-Modified Membrane and Hydrophilic Imidazolium-Based Ionic Liquid: Understanding the Mechanism of Ionic Liquid Cytotoxicity

Ionic liquids (ILs) are considered as “green solvents” for more than 2 decades. However, recent studies suggest that some ILs exhibit greater toxicity compared to common solvents. As a proactive effort to better understand the molecular origin of the cytotoxicity, the work herein presents the systemic characterization of the interaction between model membrane composed of fatty acids and popular imidazolium-based hydrophilic IL. The fusion kinetics between the vesicles demonstrates the swelling of the vesicle. Further, membrane fluidity is determined using the isomerization kinetics of a lipophilic dye, merocyanine-540, and in the presence of IL, the fluidity of the inner water pool of the vesicle is increased. The results can be directly correlated to the cytotoxicity generated by IL in K562 cell, a human erythroleukemic cell line. High-concentration IL ruptures the cell membrane and causes membrane permeabilization. Thus, the results would help to facilitate the rational design of nontoxic ILs