29 research outputs found
The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysis
Background2-dimensional Speckle-Tracking Echocardiography, to obtain longitudinal layer specific strain (LSS), has recently emerged as a novel and accurate non-invasive imaging technique for diagnosis as well as for prediction of adverse cardiac events. This systematic review and meta-analysis aimed to give an overview of the possible clinical implication and significance of longitudinal LSS.MethodsWe conducted a systematic review and meta-analysis with all the studies involving layer specific strain in patients with ischemic heart disease (IHD). Of 40 eligible studies, 9 met our inclusion criteria. Studies that were included either investigated the prognostic value (n = 3) or the diagnostic value (n = 6) of longitudinal LSS.ResultsThe pooled meta-analysis showed that longitudinal LSS is a significant diagnostic marker for coronary artery disease (CAD) in patients with IHD. Endocardial LSS was found to be a good diagnostic marker for CAD in IHD patients (OR: 1.28, CI95% [1.11–1.48], p < 0.001, per 1% decrease). Epicardial (OR: 1.34, CI95% [1.14–1.56], p < 0.001, per 1% decrease), Mid-Myocardial (OR: 1.24, CI95% [1.12–1.38], p < 0.001, per 1% decrease) and endocardial (OR: 1.21, CI95% [1.09–1.35], p < 0.001, per 1% decrease) LSS all entailed diagnostic information regarding CAD, with epicardial LSS emerging as the superior diagnostic marker for CAD in patients with SAP. Endocardial LSS proved to be the better diagnostic marker of CAD in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). LSS was shown to be a good prognostic maker of adverse cardiac events in IHD patients. Two studies found endocardial circumferential strain to be the good predictor of outcome in CAD patients and when added to baseline characteristics. Epicardial LSS emerged as best predictor in acute coronary syndrome (ACS) patients.ConclusionIn patients with SAP, epicardial LSS was the stronger diagnostic marker while in NSTE-ACS patients, endocardial LSS was the stronger diagnostic marker. In addition, endocardial circumferential strain is the better predictor of adverse outcome in CAD patients whilst in ACS patients, epicardial LSS was found to be a better predictor of outcome
Daksha: On Alert for High Energy Transients
We present Daksha, a proposed high energy transients mission for the study of
electromagnetic counterparts of gravitational wave sources, and gamma ray
bursts. Daksha will comprise of two satellites in low earth equatorial orbits,
on opposite sides of earth. Each satellite will carry three types of detectors
to cover the entire sky in an energy range from 1 keV to >1 MeV. Any transients
detected on-board will be announced publicly within minutes of discovery. All
photon data will be downloaded in ground station passes to obtain source
positions, spectra, and light curves. In addition, Daksha will address a wide
range of science cases including monitoring X-ray pulsars, studies of
magnetars, solar flares, searches for fast radio burst counterparts, routine
monitoring of bright persistent high energy sources, terrestrial gamma-ray
flashes, and probing primordial black hole abundances through lensing. In this
paper, we discuss the technical capabilities of Daksha, while the detailed
science case is discussed in a separate paper.Comment: 9 pages, 3 figures, 1 table. Additional information about the mission
is available at https://www.dakshasat.in
Science with the Daksha High Energy Transients Mission
We present the science case for the proposed Daksha high energy transients
mission. Daksha will comprise of two satellites covering the entire sky from
1~keV to ~MeV. The primary objectives of the mission are to discover and
characterize electromagnetic counterparts to gravitational wave source; and to
study Gamma Ray Bursts (GRBs). Daksha is a versatile all-sky monitor that can
address a wide variety of science cases. With its broadband spectral response,
high sensitivity, and continuous all-sky coverage, it will discover fainter and
rarer sources than any other existing or proposed mission. Daksha can make key
strides in GRB research with polarization studies, prompt soft spectroscopy,
and fine time-resolved spectral studies. Daksha will provide continuous
monitoring of X-ray pulsars. It will detect magnetar outbursts and high energy
counterparts to Fast Radio Bursts. Using Earth occultation to measure source
fluxes, the two satellites together will obtain daily flux measurements of
bright hard X-ray sources including active galactic nuclei, X-ray binaries, and
slow transients like Novae. Correlation studies between the two satellites can
be used to probe primordial black holes through lensing. Daksha will have a set
of detectors continuously pointing towards the Sun, providing excellent hard
X-ray monitoring data. Closer to home, the high sensitivity and time resolution
of Daksha can be leveraged for the characterization of Terrestrial Gamma-ray
Flashes.Comment: 19 pages, 7 figures. Submitted to ApJ. More details about the mission
at https://www.dakshasat.in
Synthesis, characterization and antimicrobial studies of some novel 3-arylazo-7 -hydroxy-4-methylcoumarins
1139-1142A series of 3-arylazo-7-hydroxy-4-methylcoumarins have been
synthesized in excellent yields (80-90%) and their structures established on
the basis of IR, 1H NMR, mass spectral data and elemental analyses.
Their purity has been ascertained by
chromatographic analysis using ethyl acetate-xylene (4:6, v/v) as irrigant. All the compounds have been tested
for their antimicrobial activity against a number of microorganisms (Agrobacterium tumefaciens, Azatobacter
spp., B. megatherium,,
B. subtilis and RhodococcuIs rhodochorus).
</span
<span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-IN;mso-fareast-language:EN-IN;mso-bidi-language:AR-SA" lang="EN-IN">Synthesis of new 2-(substituted benzothiazolylcarbamoyl)benzimidazoles as potential CNS depressants</span>
1289-1294The synthesis of a series of 2-(substituted benzothiazolyl-carbamoyl/
benzothiazolylamino-carbamoyl)benzimidazoles <b style="mso-bidi-font-weight:
normal">41-60 is reported. Their synthesis has been achieved by chloroacetylating
the substituted 2-aminobenzothiazoles and 2-
hydrazinobenzothiazoles. The N-chloroacetyl derivatives thus formed
have been reacted with o-phenylenediamine
in the presence of sulphur to afford the final products. Extension of this sequence
of reaction by incorporating certain sulphonamide-hydrazines is also described.</span
Intervention Strategies to Control <i>Campylobacter</i> at Different Stages of the Food Chain
Campylobacter is one of the most common bacterial pathogens of food safety concern. Campylobacter jejuni infects chickens by 2–3 weeks of age and colonized chickens carry a high C. jejuni load in their gut without developing clinical disease. Contamination of meat products by gut contents is difficult to prevent because of the high numbers of C. jejuni in the gut, and the large percentage of birds infected. Therefore, effective intervention strategies to limit human infections of C. jejuni should prioritize the control of pathogen transmission along the food supply chain. To this end, there have been ongoing efforts to develop innovative ways to control foodborne pathogens in poultry to meet the growing customers’ demand for poultry meat that is free of foodborne pathogens. In this review, we discuss various approaches that are being undertaken to reduce Campylobacter load in live chickens (pre-harvest) and in carcasses (post-harvest). We also provide some insights into optimization of these approaches, which could potentially help improve the pre- and post-harvest practices for better control of Campylobacter
Chromium Bioaccumulation and Its Impacts on Plants: An Overview
Chromium (Cr) is an element naturally occurring in rocky soils and volcanic dust. It has been classified as a carcinogen agent according to the International Agency for Research on Cancer. Therefore, this metal needs an accurate understanding and thorough investigation in soil–plant systems. Due to its high solubility, Cr (VI) is regarded as a hazardous ion, which contaminates groundwater and can be transferred through the food chain. Cr also negatively impacts the growth of plants by impairing their essential metabolic processes. The toxic effects of Cr are correlated with the generation of reactive oxygen species (ROS), which cause oxidative stress in plants. The current review summarizes the understanding of Cr toxicity in plants via discussing the possible mechanisms involved in its uptake, translocation and sub-cellular distribution, along with its interference with the other plant metabolic processes such as chlorophyll biosynthesis, photosynthesis and plant defensive system
The Role of Salicylic Acid in Plants Exposed to Heavy Metals
Salicylic acid (SA) is a very simple phenolic compound (a C7H6O3 compound composed of an aromatic ring, one carboxylic and a hydroxyl group) and this simplicity contrasts with its high versatility and the involvement of SA in several plant processes either in optimal conditions or in plants facing environmental cues, including heavy metal (HM) stress. Nowadays, a huge body of evidence has unveiled that SA plays a pivotal role as plant growth regulator and influences intra- and inter-plant communication attributable to its methyl ester form, methyl salicylate, which is highly volatile. Under stress, including HM stress, SA interacts with other plant hormones (e.g., auxins, abscisic acid, gibberellin) and promotes the stimulation of antioxidant compounds and enzymes thereby alerting HM-treated plants and helping in counteracting HM stress. The present literature survey reviews recent literature concerning the roles of SA in plants suffering from HM stress with the aim of providing a comprehensive picture about SA and HM, in order to orientate the direction of future research on this topic
(IAV): Influenza A Virus (IAV) detected in poultry farms of Ramechhap District.
The four farms were numbered from R1 to R4. Each sample represents pooled oral and cloacal samples. The gel was run with ladder in the first well and positive and negative controls in the last two well respectively. (TIF)</p