Emerging therapeutic agents for lung cancer

Abstract Lung cancer continues to be the most common cause of cancer-related mortality worldwide. Recent advances in molecular diagnostics and immunotherapeutics have propelled the rapid development of novel treatment agents across all cancer subtypes, including lung cancer. Additionally, more pharmaceutical therapies for lung cancer have been approved by the US Food and Drug Administration in the last 5 years than in previous two decades. These drugs have ushered in a new era of lung cancer managements that have promising efficacy and safety and also provide treatment opportunities to patients who otherwise would have no conventional chemotherapy available. In this review, we summarize recent advances in lung cancer therapeutics with a specific focus on first in-human or early-phase I/II clinical trials. These drugs either offer better alternatives to drugs in their class or are a completely new class of drugs with novel mechanisms of action. We have divided our discussion into targeted agents, immunotherapies, and antibody drug conjugates for small cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). We briefly review the emerging agents and ongoing clinical studies. We have attempted to provide the most current review on emerging therapeutic agents on horizon for lung cancer

Inventorying and pinpoint mapping of woody plants in the European and North American sectors of arboretum of the PetrSU Botanic Garden

Modern information technologies allow us to combine different types of data into a unified system and to determine a transformation of species under the new conditions of introduction (Prokhorov et al., 2013, Annenkovа, 2014). In Karelia, arboretum of the PetrSU Botanic Garden has an exceptional importance due to the species diversity and organization of planting. Regardless of the various long-term studies conducted in the arboretum, no dot distribution map of plants is available today. The article represents mapping results of more than 500 woody plants on the territory of the arboretum’s European and North American sectors. Each object has complete information about its dendrometric characteristics, phytosanitary status, and presence of epiphytic organisms found on it (fungi, lichens, mosses)

Components of the information space of Botanic Gardens. Geoinformational system of the Botanic Garden PetrSU.

Scientific and educational electronic resource "Geographic information system Botanical Garden PSU" is designed to provide social activities of the Botanical Garden, support educational and industrial practice and research students, as well as fundamental and applied research. The structure consists from base and thematic information layers. Base layers include complex topographic data in sections: land, topography, hydrography, roads, infrastructure facilities. Thematic layers represented by the following complexes: property, geological structure, the forest fund, landscapes, and special collections of plants, materials of remote sensing data

Analytical opportunities of information-analytical system on collection funds of botanical gardens

Recently, the accents in the field of application of information technologies for needs of biological collections are displaced from registration and account in area of the analysis of the data. If to determine a biodiversity, as the genetic resources, distributed in space, it is easy to make a conclusion, that one of the most powerful tools of the invesigation of biodiversity are the geoinformation systems. The estimation of taxonomy representation of col- lections of botanical gardens of Russia for different taxonomic ranks is carried out in view of influence of the ecological factors