An Exploratory Evaluation of a Treatment Mall at a State Psychiatric Hospital

The Treatment Mall is a model of inpatient psychosocial treatment provided to adults with severe mental illness to deliver recovery-oriented, evidenced-based treatment and has been implemented in state mental hospitals across the United States. The present study is an exploratory evaluation of a recently implemented Treatment Mall in a state mental hospital. To evaluate this program, the experiences of clients (N=28), staff (N=32), and administrators (N=5) were compiled using a quantitative questionnaire and focused on empowerment, skill development, and satisfaction. Additionally, data from the hospital database (N=183) were extracted and analyzed by comparing frequencies of occurrence 90 days before and 90 days after Treatment Mall implementation. The findings indicate that clients reported learning skills and were satisfied with how they were treated at the Treatment Mall. Female clients and staff viewed independent living and recovery possibilities significantly more positively than male clients and staff. Hospital performance indicators showed no significant changes pre to post implementation.

A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic

Membrane traffic between the endoplasmic reticulum (ER) and Golgi apparatus and through the Golgi apparatus is a highly regulated process controlled by members of the rab GTPase family. The GTP form of rab1 regulates ER to Golgi transport by interaction with the vesicle tethering factor p115 and the cis-Golgi matrix protein GM130, also part of a complex with GRASP65 important for the organization of cis-Golgi cisternae. Here, we find that a novel coiled-coil protein golgin-45 interacts with the medial-Golgi matrix protein GRASP55 and the GTP form of rab2 but not other Golgi rab proteins. Depletion of golgin-45 disrupts the Golgi apparatus and causes a block in secretory protein transport. These results demonstrate that GRASP55 and golgin-45 form a rab2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure

Status, Trends, and Conservation of Eelgrass in Atlantic Canada and the Northeastern United States: Workshop Report

Eelgrass (Zostera marina L) is the dominant seagrass occurring in eastern Canada and the northeastern United States, where it often forms extensive meadows in coastal and estuarine areas. Eelgrass beds are extremely productive and provide many valuable ecological functions and ecosystem services. They serve as critical feeding and nursery habitat for a wide variety of commercially and recreationally important fish and shellfish and as feeding areas for waterfowl and other waterbirds. Eelgrass detritus is also transported considerable distances to fuel offshore food webs. In addition, eelgrass beds stabilize bottom sediments, dampen wave energy, absorb nutrients from surrounding waters, and retain carbon through burial

Effect of Clouds on Shuttle Imaging

This report describes the results of the AMU's task for determining the effect of clouds on optical imaging of the Space Shuttle launch vehicle during its ascent phase from lift-off to Solid Rocket Booster (SRB) Separation. This effort was motivated by Recommendation R3.4-1 from the Columbia Accident Investigation Board Report. The AMU developed a 3-dimensional (3D) model to forecast the probability that at any time from lift-off to SRB separation, at least three of the ascent imaging cameras would have a view of the Shuttle unobstructed by cloud. Because current observational and modeling capabilities do not permit accurate forecasts of cloud morphology and location, the AMU simulated obscuration of the lines-of-sight (LOS) from a network of cameras to the Shuttle by idealized cloud-fields placed randomly within the 3D domain. For each random realization of numerous cloud-field scenarios the number of simultaneous views of the Shuttle was computed from the LOS data between lift-off and SRB separation. The percent of time with 3 simultaneous views was averaged from 100 random realizations of each scenario. Analyses of the percent of time viewable were made to determine its sensitivity to cloud amount, cloud base height, cloud thickness, cloud horizontal dimensions, and an upgrade of the camera network

The XMM Cluster Survey: Evidence for energy injection at high redshift from evolution of the X-ray luminosity-temperature relation

We measure the evolution of the X-ray luminosity-temperature (L_X-T) relation since z~1.5 using a sample of 211 serendipitously detected galaxy clusters with spectroscopic redshifts drawn from the XMM Cluster Survey first data release (XCS-DR1). This is the first study spanning this redshift range using a single, large, homogeneous cluster sample. Using an orthogonal regression technique, we find no evidence for evolution in the slope or intrinsic scatter of the relation since z~1.5, finding both to be consistent with previous measurements at z~0.1. However, the normalisation is seen to evolve negatively with respect to the self-similar expectation: we find E(z)^{-1} L_X = 10^{44.67 +/- 0.09} (T/5)^{3.04 +/- 0.16} (1+z)^{-1.5 +/- 0.5}, which is within 2 sigma of the zero evolution case. We see milder, but still negative, evolution with respect to self-similar when using a bisector regression technique. We compare our results to numerical simulations, where we fit simulated cluster samples using the same methods used on the XCS data. Our data favour models in which the majority of the excess entropy required to explain the slope of the L_X-T relation is injected at high redshift. Simulations in which AGN feedback is implemented using prescriptions from current semi-analytic galaxy formation models predict positive evolution of the normalisation, and differ from our data at more than 5 sigma. This suggests that more efficient feedback at high redshift may be needed in these models.Comment: Accepted for publication in MNRAS; 12 pages, 6 figures; added references to match published versio

The neonatal adverse event severity scale:current status, a stakeholders' assessment, and future perspectives

To support informed decisions on drug registration and prescription, clinical trials need tools to assess the efficacy and safety signals related to a given therapeutic intervention. Standardized assessment facilitates reproducibility of results. Furthermore, it enables weighted comparison between different interventions, instrumental to facilitate shared decisions. When focused on adverse events in clinical trials, tools are needed to assess seriousness, causality and severity. As part of such a toolbox, the international Neonatal Consortium (INC) developed a first version of the neonatal adverse event severity scale (NAESS). This version underwent subsequent validation in retro-and prospective trials to assess its applicability and impact on the inter-observer variability. Regulators, sponsors and academic researchers also reported on the use of the NAESS in regulatory documents, trial protocols and study reports. In this paper, we aim to report on the trajectory, current status and impact of the NAESS score, on how stakeholders within INC assess its relevance, and on perspectives to further develop this tool.</p

Principles of logic design

This study involves logic design and switching theory, in particular their practical application to the logic design and understanding of digital machines. Digital machines, of course, play an extremely important role in that large class of machines known as digital computers. But they also play an important role in many other kinds of practical devices important in the design of communications systems, digital control systems, counters, registers, digital meters, and so on. The basic content of switching theory is very simple. It embodies that body of machines and machine behavior that can be realized with "switches", things that are either "on" or "off", and nothing, really, could be much simpler than that. Of course the world is really comprised of very many complex structures which are really composed of exceedingly simple lesser structures, so that we really shouldn't be too surprised that even though the elements of switching theory are quite simple, their consequences are not necessarily so. The goals of our study are several, and include at least the following: 1) to develop some understanding and capability in using the techniques, design procedures, and models that have been developed for understanding and designing digital networks; 2) to explore in some modest detail the kinds of questions with which logic designers and practitioners concern themselves; 3) to develop an appreciation for the tremendous variation possible in digital design requirements and specifications, i. e,, for the complexity of the 'finite' digital problem, and hence an understanding of the need for systematic design techniques by which to attack such problems; 4) to gain some practice with the fundamental tools and techniques of logic design I so that the reader can adapt the techniques to the "new" problem presented by his own particular design constraints; and 5) to provide an introduction to the literature so that the discerning student can, in the future, dip into the ever growing literature in the field, and find it to some degree comprehensible, and advantageous to use

Limiting Pseudomonas aeruginosa Biofilm Formation Using Cold Atmospheric Pressure Plasma

We investigate the ability to disrupt and limit growth biofilms of Pseudomonas aeruginosa using application of cold atmospheric pressure (CAP) plasma. The effect of the bio-film's exposure to a helium (CAP) jet was assessed at varying time points during biofilm maturation. Results showed that the amount of time during biofilm growth that CAP pressure was applied has a crucial role on the ability of biofilms to mature and recover after CAP exposure. Intervention during the early stages of biofilm formation (0-8 h) results in a 4-5-log reduction in viable bacterial cells (measured at 24 h of incubation) relative to untreated biofilms. However, CAP treatment of biofilm at 12 h and above only results in a 2-log reduction in viable cells. This has potentially important implications for future clinical application of CAP to treat infected wounds