Role of KIT-Positive Interstitial Cells of Cajal in the Urinary Bladder and Possible Therapeutic Target for Overactive Bladder

In the gastrointestinal tract, interstitial cells of Cajal (ICCs) act as pacemaker cells to generate slow wave activity. Interstitial cells that resemble ICCs in the gastrointestinal tract have been identified by their morphological characteristics in the bladder. KIT is used as an identification marker of ICCs. ICCs in the bladder may be involved in signal transmission between smooth muscle bundles, from efferent nerves to smooth muscles, and from the urothelium to afferent nerves. Recent research has suggested that not only the disturbance of spontaneous contractility caused by altered detrusor ICC signal transduction between nerves and smooth muscle cells but also the disturbance of signal transduction between urothelial cells and sensory nerves via suburothelial ICC may induce overactive bladder (OAB). Recent reports have suggested that KIT is not only a detection marker of these cells, but also may play a crucial role in the control of bladder function. Research into the effect of a c-kit receptor inhibitor, imatinib mesylate, on bladder function implies that KIT-positive ICCs may be therapeutic target cells to reduce bladder overactivity and that the blockage of c-kit receptor may offer a new therapeutic strategy for OAB treatment, although further study will be needed

Isotopic evidence of plutonium release into the environment from the Fukushima DNPP accident

The Fukushima Daiichi nuclear power plant (DNPP) accident caused massive releases of radioactivity into the environment. The released highly volatile fission products, such as 129mTe, 131I, 134Cs, 136Cs and 137Cs were found to be widely distributed in Fukushima and its adjacent prefectures in eastern Japan. However, the release of non-volatile actinides, in particular, Pu isotopes remains uncertain almost one year after the accident. Here we report the isotopic evidence for the release of Pu into the atmosphere and deposition on the ground in northwest and south of the Fukushima DNPP in the 20–30 km zones. The high activity ratio of 241Pu/239+240Pu (> 100) from the Fukushima DNPP accident highlights the need for long-term 241Pu dose assessment, and the ingrowth of 241Am. The results are important for the estimation of reactor damage and have significant implication in the strategy of decontamination

The GSMaP Precipitation Retrieval Algorithm for Microwave Sounders-Part I: Over-Ocean Algorithm

Abstract-We develop an over-ocean rainfall retrieval algorithm for the Advanced Microwave Sounding Unit (AMSU) based on the Global Satellite Mapping of Precipitation (GSMaP) microwave radiometer algorithm. This algorithm combines an emissionbased estimate from brightness temperature (Tb) at 23 GHz and a scattering-based estimate from Tb at 89 GHz, depending on a scattering index (SI) computed from Tb at both 89 and 150 GHz. Precipitation inhomogeneities are also taken into account. The GSMaP-retrieved rainfall from the AMSU (GSMaP_AMSU) is compared with the National Oceanic and Atmospheric Administration (NOAA) standard algorithm (NOAA_AMSU)-retrieved data using Tropical Rainfall Measuring Mission (TRMM) data as a reference. Rain rates retrieved by GSMaP_AMSU have better agreement with TRMM estimates over midlatitudes during winter. Better estimates over multitudes over winter are given by the use of Tb at 23 GHz in the GSMaP_AMSU algorithm. It was also shown that GSMaP_AMSU has higher rain detection than NOAA_AMSU. Index Terms-Microwave radiometer (MWR), microwave sounder, precipitation, rain-rate retrieval

Novel prospective umbrella-type lung cancer registry study for clarifying clinical practice patterns: CS-Lung-003 study protocol

Introduction Conventional cancer registries are suitable for simple surveillance of cancer patients, including disease frequency and distribution, demographics, and prognosis; however, the collected data are inadequate to clarify comprehensively diverse clinical questions in daily practice. Methods We constructed an umbrella‐type lung cancer patient registry (CS‐Lung‐003) integrating multiple related prospective observational studies (linked studies) that reflect clinical questions about lung cancer treatment. The primary endpoint of this registry is to clarify daily clinical practice patterns in lung cancer treatment; a key inclusion criterion is pathologically diagnosed lung cancer. Under this registry, indispensable clinical items are detected in advance across all active linked studies and gathered prospectively and systematically to avoid excessive or insufficient data collection. Researchers are to input information mutually, irrespective of the relevance to each researcher's own study. Linked studies under the umbrella of the CS‐Lung‐003 registry will be updated annually with newly raised clinical questions; some linked studies will be newly created, while others will be deleted after the completion of the analysis. Enrollment began in July 2017. Discussion We successfully launched the umbrella‐type CS‐Lung‐003 registry. Under this single registry, researchers collaborate on patient registration and data provision for their own and other studies. Thus, the registry will produce results for multiple domains of study, providing answers to questions about lung cancer treatment raised by other researchers. Through such analysis of each linked study, this registry will contribute to the comprehensive elucidation of actual daily practice patterns in lung cancer treatment. Key points CS‐Lung‐003 registry directly integrates multiple linked studies created under the umbrella of this cancer registry to solve various clinical questions regarding daily practice patterns of lung cancer treatment

Clinical Characteristics of Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis Complex.

Background: This study evaluated the characteristics of subependymal giant cell astrocytoma (SEGA) in patients with tuberous sclerosis complex (TSC) entered into the TuberOus SClerosis registry to increase disease Awareness (TOSCA). Methods: The study was conducted at 170 sites across 31 countries. Data from patients of any age with a documented clinical visit for TSC in the 12 months preceding enrollment or those newly diagnosed with TSC were entered. Results: SEGA were reported in 554 of 2,216 patients (25%). Median age at diagnosis of SEGA was 8 years (range, 18 years. SEGA were symptomatic in 42.1% of patients. Symptoms included increased seizure frequency (15.8%), behavioural disturbance (11.9%), and regression/loss of cognitive skills (9.9%), in addition to those typically associated with increased intracranial pressure. SEGA were significantly more frequent in patients with TSC2 compared to TSC1 variants (33.7 vs. 13.2 %, p < 0.0001). Main treatment modalities included surgery (59.6%) and mammalian target of rapamycin (mTOR) inhibitors (49%). Conclusions: Although SEGA diagnosis and growth typically occurs during childhood, SEGA can occur and grow in both infants and adults

Neutral atmosphere dynamics in the E- and F-regions from Fabry-Perot Doppler imaging observations

In order to investigate a response of the thermospheric neutral winds to the auroral activity, we developed a Fabry-Perot Doppler Imaging System (FPDIS) which measures Doppler shifts and widths of aurora and/or airglow emission lines of OI557.7nm and OI630.0nm over a wide field of view (165°) to obtain twodimensional patterns of winds and temperatures in the E-and F-regions. We carried out the FPDIS observations at Syowa Station (69.00°S, 39.58°E), Antarctica over 57 nights covering the various auroral conditions in 1994. In this paper, we discuss the following results obtained from our observations : (1) We found that nighttime variations in the thermospheric neutral winds depend on geomagnetic activity. Magnetically southward winds during geomagnetically active periods were stronger than during quiet periods, and the difference in the wind velocities was largest around midnight. This difference is supposed to be associated with auroral energy injection and the relative location between the auroral oval and Syowa Station. (2) Periodic enhancements in meridional winds, which were classified into middle-scale atmospheric gravity waves (AGWs), were observed on the night of 3-4 June 1994 during geomagnetically active periods. These wind enhancements appeared to be generated in the auroral oval which remained at a few hundred kilometers north of Syowa Station

Improvement of TMI Rain Retrievals in Mountainous Areas

Heavy rainfall associated with shallow orographic rainfall systems has been underestimated by passive microwave radiometer algorithms owing to weak ice scattering signatures. The authors improve the performance of estimates made using a passive microwave radiometer algorithm, the Global Satellite Mapping of Precipitation (GSMaP) algorithm, from data obtained by the Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI) for orographic heavy rainfall. An orographic/nonorographic rainfall classification scheme is developed on the basis of orographically forced upward vertical motion and the convergence of surface moisture flux estimated from ancillary data. Lookup tables derived from orographic precipitation profiles are used to estimate rainfall for an orographic rainfall pixel, whereas those derived from original precipitation profiles are used to estimate rainfall for a nonorographic rainfall pixel. Rainfall estimates made using the revised GSMaP algorithm are in better agreement with estimates from data obtained by the radar on the TRMM satellite and by gauge-calibrated ground radars than are estimates made using the original GSMaP algorithm