403 research outputs found
A Bass Diffusion Model Analysis: Understanding Alternative Fuel Vehicle Sales
Frank M. Bass developed the Bass Diffusion Model to predict how innovative consumer durable products diffuse through consumer markets. This thesis will use data from 1999-2011 to examine the applicability of the Bass Diffusion Model to the introduction of alternative fuel vehicles (AFVs) in the automobile market. The findings in this thesis indicate the Bass Diffusion Model fit the diffusion pattern exhibited by AFVs well, but failed to accurately forecast diffusion patterns outside a given range of data. This thesis investigates potential reasons for the inaccurate \u27Out of Sample Forecast\u27, and gives recommendations for directions of future research on AFV diffusion
Effects of electrical charging on the mechanical Q of a fused silica disk
We report on the effects of an electrical charge on mechanical loss of a
fused silica disk. A degradation of Q was seen that correlated with charge on
the surface of the sample. We examine a number of models for charge damping,
including eddy current damping and loss due to polarization. We conclude that
rubbing friction between the sample and a piece of dust attracted by the
charged sample is the most likely explanation for the observed loss.Comment: submitted to Review of Scientific Instrument
Michelson interferometer with diffractively-coupled arm resonators in second-order Littrow configuration
Michelson-type laser-interferometric gravitational-wave (GW) observatories
employ very high light powers as well as transmissively- coupled Fabry-Perot
arm resonators in order to realize high measurement sensitivities. Due to the
absorption in the transmissive optics, high powers lead to thermal lensing and
hence to thermal distortions of the laser beam profile, which sets a limit on
the maximal light power employable in GW observatories. Here, we propose and
realize a Michelson-type laser interferometer with arm resonators whose
coupling components are all-reflective second-order Littrow gratings. In
principle such gratings allow high finesse values of the resonators but avoid
bulk transmission of the laser light and thus the corresponding thermal beam
distortion. The gratings used have three diffraction orders, which leads to the
creation of a second signal port. We theoretically analyze the signal response
of the proposed topology and show that it is equivalent to a conventional
Michelson-type interferometer. In our proof-of-principle experiment we
generated phase-modulation signals inside the arm resonators and detected them
simultaneously at the two signal ports. The sum signal was shown to be
equivalent to a single-output-port Michelson interferometer with
transmissively-coupled arm cavities, taking into account optical loss. The
proposed and demonstrated topology is a possible approach for future
all-reflective GW observatory designs
Asymmetric WIMP dark matter
In existing dark matter models with global symmetries the relic abundance of
dark matter is either equal to that of anti-dark matter (thermal WIMP), or
vastly larger, with essentially no remaining anti-dark matter (asymmetric dark
matter). By exploring the consequences of a primordial asymmetry on the coupled
dark matter and anti-dark matter Boltzmann equations we find large regions of
parameter space that interpolate between these two extremes. Interestingly,
this new asymmetric WIMP framework can accommodate a wide range of dark matter
masses and annihilation cross sections. The present-day dark matter population
is typically asymmetric, but only weakly so, such that indirect signals of dark
matter annihilation are not completely suppressed. We apply our results to
existing models, noting that upcoming direct detection experiments will
constrain a large region of the relevant parameter space.Comment: 32 pages, 6 figures, updated references, updated XENON100 bounds,
typo in figure caption correcte
Seismic isolation of Advanced LIGO: Review of strategy, instrumentation and performance
The new generation of gravitational waves detectors require unprecedented levels of isolation from seismic noise. This article reviews the seismic isolation strategy and instrumentation developed for the Advanced LIGO observatories. It summarizes over a decade of research on active inertial isolation and shows the performance recently achieved at the Advanced LIGO observatories. The paper emphasizes the scientific and technical challenges of this endeavor and how they have been addressed. An overview of the isolation strategy is given. It combines multiple layers of passive and active inertial isolation to provide suitable rejection of seismic noise at all frequencies. A detailed presentation of the three active platforms that have been developed is given. They are the hydraulic pre-isolator, the single-stage internal isolator and the two-stage internal isolator. The architecture, instrumentation, control scheme and isolation results are presented for each of the three systems. Results show that the seismic isolation sub-system meets Advanced LIGO's stringent requirements and robustly supports the operation of the two detectors.Laser Interferometer Gravitational-Wave ObservatoryNational Science Foundation (U.S.
GRB Light Curves in the Relativistic Turbulence Model
Randomly oriented relativistic emitters in a relativistically expanding shell
provides an alternative to internal shocks as a mechanism for producing GRBs'
variable light curves with efficient conversion of energy to radiation. In this
model the relativistic outflow is broken into small emitters moving
relativistically in the outflow's rest frame. Variability arises because an
observer sees an emitter only when its velocity points towards him so that only
a small fraction of the emitters are seen by a given observer. Models with
significant relativistic random motions require converting and maintaining a
large fraction of the overall energy into these motions. While it is not clear
how this is achieved, we explore here, using two toy models, the constraints on
parameters required to produce light curves comparable to the observations. We
find that a tight relation between the size of the emitters and the bulk and
random Lorentz factors is needed and that the random Lorentz factor determines
the variability. While both models successfully produce the observed
variability there are several inconsistencies with other properties of the
light curves. Most of which, but not all, might be resolved if the central
engine is active for a long time producing a number of shells, resembling to
some extent the internal shocks model.Comment: Significantly revised with a discussion of additional models.
Accepted for publication in APJ
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants
The recent emergence of multiple SARS-CoV-2 variants has caused considerable concern due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It is, therefore, paramount to develop therapeutic strategies that inhibit all known and future SARS-CoV-2 variants. Here, we report that all SARS-CoV-2 variants analyzed, including variants of concern (VOC) Alpha, Beta, Gamma, Delta, and Omicron, exhibit enhanced binding affinity to clinical grade and phase 2 tested recombinant human soluble ACE2 (APN01). Importantly, soluble ACE2 neutralized infection of VeroE6 cells and human lung epithelial cells by all current VOC strains with markedly enhanced potency when compared to reference SARS-CoV-2 isolates. Effective inhibition of infections with SARS-CoV-2 variants was validated and confirmed in two independent laboratories. These data show that SARS-CoV-2 variants that have emerged around the world, including current VOC and several variants of interest, can be inhibited by soluble ACE2, providing proof of principle of a pan-SARS-CoV-2 therapeutic
Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy
Simian immunodeficiency virus (SIV) insert-expressing, 68–1 Rhesus Cytomegalovirus (RhCMV/SIV) vectors elicit major histocompatibility complex (MHC)-E- and -II-restricted, SIV-specific CD8(+) T cell responses, but the basis of these unconventional responses and their contribution to demonstrated vaccine efficacy against SIV challenge in the rhesus monkeys (RMs) has not been characterized. We show that these unconventional responses resulted from a chance genetic rearrangement in 68–1 RhCMV that abrogated the function of eight distinct immunomodulatory gene products encoded in two RhCMV genomic regions (Rh157.5/Rh157.4 and Rh158–161), revealing three patterns of unconventional response inhibition. Differential repair of these genes with either RhCMV-derived or orthologous human CMV (HCMV)-derived sequences (UL128/UL130; UL146/UL147) leads to either of two distinct CD8(+) T cell response types – MHC-Ia-restricted-only, or a mix of MHC-II- and MHC-Ia-restricted CD8(+) T cells. Response magnitude and functional differentiation are similar to RhCMV 68–1, but neither alternative response type mediated protection against SIV challenge. These findings implicate MHC-E-restricted CD8(+) T cell responses as mediators of anti-SIV efficacy and indicate that translation of RhCMV/SIV vector efficacy to humans will likely require deletion of all genes that inhibit these responses from the HCMV/HIV vector
Testing gravitational-wave searches with numerical relativity waveforms: Results from the first Numerical INJection Analysis (NINJA) project
The Numerical INJection Analysis (NINJA) project is a collaborative effort
between members of the numerical relativity and gravitational-wave data
analysis communities. The purpose of NINJA is to study the sensitivity of
existing gravitational-wave search algorithms using numerically generated
waveforms and to foster closer collaboration between the numerical relativity
and data analysis communities. We describe the results of the first NINJA
analysis which focused on gravitational waveforms from binary black hole
coalescence. Ten numerical relativity groups contributed numerical data which
were used to generate a set of gravitational-wave signals. These signals were
injected into a simulated data set, designed to mimic the response of the
Initial LIGO and Virgo gravitational-wave detectors. Nine groups analysed this
data using search and parameter-estimation pipelines. Matched filter
algorithms, un-modelled-burst searches and Bayesian parameter-estimation and
model-selection algorithms were applied to the data. We report the efficiency
of these search methods in detecting the numerical waveforms and measuring
their parameters. We describe preliminary comparisons between the different
search methods and suggest improvements for future NINJA analyses.Comment: 56 pages, 25 figures; various clarifications; accepted to CQ
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