МОТИВ ДЕНЕГ В РОМАНЕ Ф.М. ДОСТОЕВСКОГО "ПОДРОСТОК"

Consideration of the motif of money in the novel “Teenager” allows to trace its influence on the structure of the personality of the main characters, their psychology and the formation of a life strategy. Inside the novel, he interacts with other motifs: motif of joking, a lost generation, the ideal of a beautiful person and his spiritual imperfection. In the structure of the novel, it also influences the arrangement of images and polarization of the image system, the accentuation of the ideological and artistic dominant and the specific use of important artistic details, such as, for example, sacral numbers.Рассмотрение мотива денег в романе «Подросток» позволяет проследить его влияние на структуру личности главных героев, их психологию и формирование жизненной стратегии. Внутри романа он взаимодействует с другими мотивами: мотивами шутовства, потерянного поколения, идеалом прекрасного человека и его духовного несовершенства. В структуре романа он оказывает влияние также на расстановку образов и поляризацию образной системы, акцентирование идейно-художественной доминанты и специфику использования важных художественных деталей, таких, например, как сакральные числа

A POSSIBILITY TO USE ANTIARRHYTHMIC MEDICATIONS FROM II CLASS AND MODULATED KINESITHERAPY AS PRIMARY PREVENTION OF ATRIAL FIBRILLATION IN METABOLIC SYNDROME PATIENTS

Aim. To evaluate the usage of II class antiarrhythmic drugs and modulated kinesitherapy (MK) as primary prevention of atrial fibrillation (AF) in patients with metabolic syndrome (MS) with revelation of short-term risk for this arrhythmia development.Material and methods. We observed 153 patients with MS at the age 58-75 y. o. without AF in anamnesis, but with short-term risk of its development (2 years after examination), defined via comparative analysis of AF course, induced by transesophageal electrocardiostimulation, in dynamic patients observation. All patients, as primary prevention of AF, used antiarrhythmics of the 2nd class, and in side effects development or in contraindications they underwent MK; polyunsaturated fatty acids also used (PUFA).Results. After inclusion to the study 77 (50,33%) of MS patients used II class drugs additionally to therapy, 42 (27,45%) patients underwent MK, and the rest used PUFA. The best clinical effect was found in II class drugs and MK >63,75% and 74,41%, resp. Efficacy of the therapy in this type of patients highly correlated with the improvement of the left ventricle dysfunction, signal-average electrocardiogram, P-wave dispersion and the decrease of the left atrium volume.Conclusion. If the short-term risk of AF found in MS patients, as primary prevention the method of choice is antiarrhythmic therapy II class drugs and MK

THE GROWTH OF MESENCHYMAL STEM CELLS ON THE SURFACE OF MAGNETIC CONDUITS FOR NERVE TISSUE ENGINEERING IN AN ALTERNATING MAGNETIC FIELD

Novel magnetic nerve guidance conduits were fabricated by electrospinning. Physico-chemical and biological properties of the conduits were comprehensively investigated. The composite conduits were shown to support cell proliferation, and thereby are prospective for use in tissue engineering.Исследование выполнено при финансовой поддержке РНФ (проект № 20-63-47096). Выражаем благодарность кафедре биоинженерии МГУ им. М.В. Ломоносова под руководством А.П. Бонарцева за проведение клеточных исследований; Мухортовой Ю.Р. за помощь в синтезе магнетита и Парию И. за проведение измерений АСМ

Structure and Physico-Mechanical Properties of PHB/Magnetite Scaffolds after Biodegradation in Vitro

Hydrolytic and enzymatic biodegradation of electrospun hybrid PHB/Fe3O4 scaffolds with addition of submicron and nanoparticles of magnetite has been performed. Properties of scaffolds before and after immersion into PBS and lipase have been investigated by X-ray diffraction and tensile test.Авторы выражают благодарность коллективу кафедры биоинженерии Московского государственного университета им М. В. Ломоносова под руководством Бонарцева А. П. за проведение экспериментов по биодеградации. Исследование выполнено при финансовой поддержке РНФ (проект № 20-63-47096)

Electrospun magnetic composite poly-3-hydroxybutyrate/magnetite scaffolds for biomedical applications: composition, structure, magnetic properties, and biological performance

Magnetically responsive composite polymer scaffolds have good potential for a variety of biomedical applications. In this work, electrospun composite scaffolds made of polyhydroxybutyrate (PHB) and magnetite (Fe3O4) particles (MPs) were studied before and after degradation in either PBS or a lipase solution. MPs of different sizes with high saturation magnetization were synthesized by the coprecipitation method followed by coating with citric acid (CA). Nanosized MPs were prone to magnetite-maghemite phase transformation during scaffold fabrication, as revealed by Raman spectroscopy; however, for CA-functionalized nanoparticles, the main phase was found to be magnetite, with some traces of maghemite. Submicron MPs were resistant to the magnetite-maghemite phase transformation. MPs did not significantly affect the morphology and diameter of PHB fibers. The scaffolds containing CA-coated MPs lost 0.3 or 0.2% of mass in the lipase solution and PBS, respectively, whereas scaffolds doped with unmodified MPs showed no mass changes after 1 month of incubation in either medium. In all electrospun scaffolds, no alterations of the fiber morphology were observed. Possible mechanisms of the crystalline-lamellar-structure changes in hybrid PHB/Fe3O4 scaffolds during hydrolytic and enzymatic degradation are proposed. It was revealed that particle size and particle surface functionalization affect the mechanical properties of the hybrid scaffolds. The addition of unmodified MPs increased scaffolds' ultimate strength but reduced elongation at break after the biodegradation, whereas simultaneous increases in both parameters were observed for composite scaffolds doped with CA-coated MPs. The highest saturation magnetization-higher than that published in the literature-was registered for composite PHB scaffolds doped with submicron MPs. All PHB scaffolds proved to be biocompatible, and the ones doped with nanosized MPs yielded faster proliferation of rat mesenchymal stem cells. In addition, all electrospun scaffolds were able to support angiogenesis in vivo at 30 days after implantation in Wistar rats

МОТИВ ДЕНЕГ В РОМАНЕ Ф.М. ДОСТОЕВСКОГО "ПОДРОСТОК"

Consideration of the motif of money in the novel “Teenager” allows to trace its influence on the structure of the personality of the main characters, their psychology and the formation of a life strategy. Inside the novel, he interacts with other motifs: motif of joking, a lost generation, the ideal of a beautiful person and his spiritual imperfection. In the structure of the novel, it also influences the arrangement of images and polarization of the image system, the accentuation of the ideological and artistic dominant and the specific use of important artistic details, such as, for example, sacral numbers.Рассмотрение мотива денег в романе «Подросток» позволяет проследить его влияние на структуру личности главных героев, их психологию и формирование жизненной стратегии. Внутри романа он взаимодействует с другими мотивами: мотивами шутовства, потерянного поколения, идеалом прекрасного человека и его духовного несовершенства. В структуре романа он оказывает влияние также на расстановку образов и поляризацию образной системы, акцентирование идейно-художественной доминанты и специфику использования важных художественных деталей, таких, например, как сакральные числа

THE ROLE OF THE MOTIF OF MONEY IN THE F.M. DOSTOEVSKY’S NOVEL “TEENAGER”

Consideration of the motif of money in the novel “Teenager” allows to trace its influence on the structure of the personality of the main characters, their psychology and the formation of a life strategy. Inside the novel, he interacts with other motifs: motif of joking, a lost generation, the ideal of a beautiful person and his spiritual imperfection. In the structure of the novel, it also influences the arrangement of images and polarization of the image system, the accentuation of the ideological and artistic dominant and the specific use of important artistic details, such as, for example, sacral numbers

Screening of phytopathogens and phytopathoges on Chenomeles (CHAENOMELES LINDL.) cultivars

The pathogenic microflora and entomofauna were studied on the Chaenomeles Lindl. cutivars (Maloideae, Rosaceae). In central Russia, the multi-year systematic monitoring of pathogens and phytophages was carried out on plants Ch. japonica, Ch. cathayensis, Ch. ×superba. Among the identified pathogens, the micromycetes belonging to genera Botrytis, Cytospora, Diplocarpon, Entomosporium, Gloeosporium, Monilia, Neonectria, Penicillium, Pestalotia, Phomopsis, Phyllosticta, Septoria and Sphaeropsis were found to be injurious. With age, the accumulation of infectious background, including viral diseases and the damaging entomofauna was noted in the plantings of fruit crop Chaenomeles. The species composition of phytophages is mainly represented by autochthonous species (polyphages and oligophages), preferring the plants of Rosaceae family. Despite the abundance of species in the phytophage complex, it has a little effect on the decorativeness of Ch. japonica, Ch. cathayensis and Ch. × superba