Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles

AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug-dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and silver NPs, are explored. Recent advances, current challenges and future perspectives on the use of these NMs for better management of HIV/AIDS are also discussed. Plain language summary AIDS is a disease affecting many worldwide. Since it is difficult to cure AIDS, new therapies have been developed. Tiny materials called nanoparticles with promising features are used to carry different drugs to relevant organs in the body. There are various nanoparticles with different textures and shapes used in AIDS therapy. Branched nanoparticles, nanoparticles with repetitive building blocks and metal-based nanoparticles are three commonly used nanoparticles in AIDS treatment that are studied in this review. These tiny materials can find the exact place in the body to deliver drugs. They can also reduce the side effects of anti-AIDS drugs and help patients use fewer drugs while getting the same or better results. Tweetable abstract In this review, recent advances, current challenges and future perspectives in the use of liposomal-based delivery systems and inorganic nanoparticles (including gold and silver nanoparticles) for better management of HIV/AIDS are critically discussed

Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements

Over the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to their several advantageous. However, rod-shaped gold nanoparticles, or gold nanorods (GNRs), have some more unique physical, optical, and chemical properties, making them proper candidates for biomedical applications including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. Most of their therapeutic applications are based on their ability for tunable heat generation upon exposure to near-infrared (NIR) radiation, which is helpful in both NIR-responsive cargo delivery and photothermal/photodynamic therapies. In this review, a comprehensive insight into the properties, synthesis methods and toxicity of gold nanorods are overviewed first. For the main body of the review, the therapeutic applications of GNRs are provided in four main sections: (i) drug delivery, (ii) gene delivery, (iii) photothermal/photodynamic therapy, and (iv) theranostics applications. Finally, the challenges and future perspectives of their therapeutic application are discussed

Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles Supplementary Dataset

AIDS causes increasing mortality every year.With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and silver NPs, are explored. Recent advances, current challenges and future perspectives on the use of these NMs for better management of HIV/AIDS are also discussed.</p