An Analysis of the Rising Xenophobia Against Asian Americans in the U.S. and Higher Education Regarding the Effects of the COVID-19 Pandemic

This paper analyzes the cause of anti-Asian hate, the rising xenophobia against people with Asian origins, as well as the vaccine distribution and governmental leadership. By conducting a short case study on universities’ leadership during the COVID-19 Pandemic in the United States, this paper contributes to the literature regarding Asian Americans overall, as well as to the literature on approaches to a public crisis on hate crime in higher education in the United States

Single Image Deraining via Rain-Steaks Aware Deep Convolutional Neural Network

It is challenging to remove rain-steaks from a single rainy image because the rain steaks are spatially varying in the rainy image. This problem is studied in this paper by combining conventional image processing techniques and deep learning based techniques. An improved weighted guided image filter (iWGIF) is proposed to extract high frequency information from a rainy image. The high frequency information mainly includes rain steaks and noise, and it can guide the rain steaks aware deep convolutional neural network (RSADCNN) to pay more attention to rain steaks. The efficiency and explain-ability of RSADNN are improved. Experiments show that the proposed algorithm significantly outperforms state-of-the-art methods on both synthetic and real-world images in terms of both qualitative and quantitative measures. It is useful for autonomous navigation in raining conditions

Factors influencing employee job satisfaction and turnover intention in companies in China

In China, the actual employee turnover rate is relatively high and the employee's job satisfaction is at a medium level, so the research on employee job satisfaction and turnover intention is still very important. This dissertation investigates employees who have had work experience in China, using quantitative research methods, mainly researches the relationship between six influencing factors (income, employment status, corporate culture, colleague relationships, leader-employee relationship, job content) and employees' job satisfaction and turnover intention, and examines the mediating role of job satisfaction. The researcher analyzed the collected data through SPSS software and concluded that job satisfaction can significantly negatively affect turnover intention. Among the six influencing factors, corporate culture has the most significant impact on job satisfaction. In addition, job satisfaction played a mediating role in all six influencing factors explored and turnover intention, and was analyzed in comparison with previous literature. Finally, the implications and limitations of this dissertation are discussed, and the researcher provides relevant suggestions for stakeholders, which can reduce employees' turnover intention by improving their job satisfaction

Stimulation of hair growth by Tianma Gouteng decoction: Identifying mechanisms based on chemical analysis, systems biology approach, and experimental evaluation

Hair serves important physiological functions, including temperature regulation and scalp protection. However, excessive shedding not only impacts these functions but can also significantly affect mental health and quality of life. Tianma Gouteng decoction (TGD) is a traditional Chinese medicine used for the treatment of various conditions, including hair loss. However, the associated mechanism underlying its anti-alopecia effect remains unknown. Therefore, this study aims to elucidate these mechanisms by employing systematic biology approaches, as well as in vitro and in vivo experimental validation. The chemical constituents of Tianma Gouteng decoction were identified using UHPLC-MS/MS, from which 39 potential bioactive components were screened, while an additional 131 putative Tianma Gouteng decoction beneficial components were extracted from the Traditional Chinese Medicine Database and Analysis Platform (TCMSP) database. We then applied a dual-dimensional network pharmacology approach to analyze the data, followed by validation studies combining molecular docking techniques with in vivo and in vitro experiments. From the 39 bioactive components, including quercetin, luteolin, fisetin, wogonin, oroxylin A, boldine, tetrahydroalstonine, and galangin A, 782 corresponding targets were identified. In particular, GSK3β and β-catenin exhibited strong binding activity with the bioactive compounds. Hence, construction of a bioactive component-target network revealed that the mechanism underlying the anti-alopecia mechanism of Tianma Gouteng decoction primarily involved the Wnt/β-catenin signaling pathway. Moreover, C57BL/6J mice exhibited measurable improvements in hair follicle regeneration following treatment with Tianma Gouteng decoction. Additionally, β-catenin and p-GSK3β levels were upregulated, while GSK3β was downregulated in Tianma Gouteng decoction-treated animals and dermal papilla cells compared to control group. These in vivo and in vitro outcomes validated the targets and pathways predicted in the network pharmacology analysis of Tianma Gouteng decoction. This study provides a systematic analysis approach to identify the underlying anti-alopecia mechanisms of Tianma Gouteng decoction, further providing theoretical support for clinical assessment of Tianma Gouteng decoction

TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes

Numerous studies have highlighted the importance of high-affinity interactions between T cell receptors (TCRs) and their ligands in the selection of Foxp3+ regulatory T cells (T reg cells). To determine the role of the TCR in directing T cells into the Foxp3+ lineage, we generated transgenic (Tg) mice expressing TCRs from Foxp3+ cells. Initial analyses of the TCR Tg mice crossed with RAG-deficient mice showed that the percentage of Foxp3+ cells was very low. However, intrathymic injection and bone marrow chimera experiments showed a saturable increase of the Foxp3+ population when T reg TCR Tg cells were present in low numbers. Furthermore, when analyzing whole thymi of T reg TCR Tg RAG-deficient mice, we found significantly more Foxp3+ cells than in conventional T cell TCR Tg mice. Our results indicate that although the TCR has an instructive role in determining Foxp3 expression, selection of Foxp3+ individual clones in the thymus is limited by a very small niche

Factors influencing employee job satisfaction and turnover intention in companies in China

In China, the actual employee turnover rate is relatively high and the employee's job satisfaction is at a medium level, so the research on employee job satisfaction and turnover intention is still very important. This dissertation investigates employees who have had work experience in China, using quantitative research methods, mainly researches the relationship between six influencing factors (income, employment status, corporate culture, colleague relationships, leader-employee relationship, job content) and employees' job satisfaction and turnover intention, and examines the mediating role of job satisfaction. The researcher analyzed the collected data through SPSS software and concluded that job satisfaction can significantly negatively affect turnover intention. Among the six influencing factors, corporate culture has the most significant impact on job satisfaction. In addition, job satisfaction played a mediating role in all six influencing factors explored and turnover intention, and was analyzed in comparison with previous literature. Finally, the implications and limitations of this dissertation are discussed, and the researcher provides relevant suggestions for stakeholders, which can reduce employees' turnover intention by improving their job satisfaction