Influence of Cement Industry on Global Climate Change

The article deals with global climate change for few last decades and establishes relation between CO2 concentration and global climate change. Summarized influence of manufacturing of cement and concrete on world’s CO2 emission. Effective supplementary cementitious material like fly ash, slag and silica fume were proposed

Use of monitoring system in Ekaterinburg

The monitoring of buildings and structures condition, as well as the timely implementation of corrective actions aimed at the elimination of adverse factors, are the most important aspects that shall be addressed at the construction stage. The usage of monitoring systems makes it possible to monitor the building condition and above that to implement more efficient design solutions in the prospective projects using the results of the analysis of the acquired and design data. In this work the review of a monitoring system installed in a high-rise building located in Ekaterinburg is given. The paper describes the analysis of the natural oscillation frequency and the logarithmic decrement of fundamental tone acquired with the help of accelerometers, and compares the values with the acceptance limits. The process of converting data acquired by strain gauges for the determination of the stress-strain condition of the bearing structures is analysed. The process of comparison of data obtained by the monitoring system of a high-rise building is described. The necessity of the application of the monitoring system is analysed. © Published under licence by IOP Publishing Ltd

Maximal and repeated muscular efforts: ergometric and physiological evaluation criteria

The pre-versus post-experimental 5s maximal strength tests of the isometric contractions of rectus femoris found significant progress in the following test rates: peak force by 10.4%; maximal strength by 13.3% and force impulse by 15.5%. The pre-versus post-experimental 1min maximal strength keeping tests found significant progress in the following test rates: peak force by 11.2%; maximal strength by 15.2%; maximal strength reaching time by 14.6%; and the 97% maximal strength reaching time by 15.8

Results of surgical treatment of postinfarction left ventricular aneurysm complicated with ventricular tachycardia with use of 3D-navigation system CARTO™

The aim of the research was to study localization of wandering focus and effectiveness of extensive endocardectomy at left ventricular reconstruction in patients with ischemic heart disease (IHD) with postinfarction left ventricular aneurysm (LVA) in combination with ventricular tachycardia (VT). Examined patients besides diagnostic routines had intracardiac electrophysiological examination (EPE) with use of 3D-navigation system CARTOTX (Biosense Webster). During EPE abnormal zones of delayed navigating and zones of double potential with main localization in the area of cacuminal and middle septate segments were found. All patients were divided into two groups: patients of the first group had aortocoronary bypass (ACB) in combination with left ventricular reconstruction completed with extended resection of endocardium with pinch of all cacuminal and middle septate segments; 2 patients of the second group had isolated ACB, 2 patients had ACB with mitral annuloplasty with rim and de Vega plasty of tricuspid valve, 1 patient had percutaneous transluminal coronary angioplasty, 10 patients hadACB in combination with LVA plasty without extended endocardium resection. As the result of the treatment in the first group there were no VT episodes after resection of aneurysm with extended endocardium resection; 33 % of patients in the second group had implantable cardioverter defibrillator, 7 % of the patients had radio frequency ablation of VT nidus, 7 % of the patients had anti-arrhythmic therapy. Taking into consideration that main localization of ectopic nidus in patients with IHD with postinfarction LVA and VT is in the area of cacuminal and middle septate segments, left ventricular reconstruction in these patients needs to be conducted with extended resection of endocardium of these segments

Outbreak of West Nile virus infection, Volgograd Region, Russia, 1999.

From July 25 to October 1, 1999, 826 patients were admitted to Volgograd Region, Russia, hospitals with acute aseptic meningoencephalitis, meningitis, or fever consistent with arboviral infection. Of 84 cases of meningoencephalitis, 40 were fatal. Fourteen brain specimens were positive in reverse transcriptase-polymerase chain reaction assays, confirming the presence of West Nile/Kunjin virus

Genetic Biomarkers of Antipsychotic-Induced Prolongation of the QT Interval in Patients with Schizophrenia.

Antipsychotics (AP) induced prolongation of the QT interval in patients with schizophrenia (Sch) is an actual interdisciplinary problem as it increases the risk of sudden death syndrome. Long QT syndrome (LQTS) as a cardiac adverse drug reaction is a multifactorial symptomatic disorder, the development of which is influenced by modifying factors (APs' dose, duration of APs therapy, APs polytherapy, and monotherapy, etc.) and non-modifying factors (genetic predisposition, gender, age, etc.). The genetic predisposition to AP-induced LQTS may be due to several causes, including causal mutations in the genes responsible for monoheme forms of LQTS, single nucleotide variants (SNVs) of the candidate genes encoding voltage-dependent ion channels expressed both in the brain and in the heart, and SNVs of candidate genes encoding key enzymes of APs metabolism. This narrative review summarizes the results of genetic studies on AP-induced LQTS and proposes a new personalized approach to assessing the risk of its development (low, moderate, high). We recommend implementation in protocols of primary diagnosis of AP-induced LQTS and medication dispensary additional observations of the risk category of patients receiving APs, deoxyribonucleic acid profiling, regular electrocardiogram monitoring, and regular therapeutic drug monitoring of the blood APs levels

Comparative analysis of Illumina and Ion Torrent high-throughput sequencing platforms for identification of plant components in herbal teas

© 2018 Elsevier Ltd The rapid development of high-throughput sequencing (HTS) methods offers new opportunities for food quality control and identification of food components using the DNA barcoding approach (metabarcoding in cases of complex mixes). However, the protocols of DNA barcoding applied to food analysis are not yet fully established; testing and optimization are required to achieve the highest accuracy and cost efficiency. We report here a comparative study of the two most widely used sequencing platforms - Illumina and Ion Torrent - for composition analysis of herbal teas, and show that both technologies yield congruent results, both qualitatively and quantitatively. They have revealed the substitution of fireweed (Epilobium angustifolium L.) by Lythrum sp. in one of the samples. It was confirmed by classic methods of botanical analysis (anatomy and palynology). In most samples, undeclared components have been detected, such as bindweed (Convolvulus) and ragweed (Ambrosia), which are known toxic and allergy-causing plants

Дифференциация и субпопуляционный состав VEGFR2+ моноцитов крови и костного мозга при ишемической кардиомиопатии

Aim. To identify disturbances of differentiation and subpopulation composition of VEGFR2+ cells in the blood and bone marrow associated with the features of the cytokine profile in the blood and bone marrow in patients with coronary artery disease (CAD) with and without ischemic cardiomyopathy (ICM).Materials and methods. The study included 74 patients with СAD with and without ICM (30 and 44 people, respectively) and 18 healthy donors. In all patients with СAD, peripheral blood sampling was performed immediately before coronary artery bypass grafting, and bone marrow samples were taken during the surgery via a sternal incision. In the healthy donors, only peripheral blood sampling was performed. In the bone marrow and blood samples, the number of VEGFR2+ cells (CD14+VEGFR2+ cells) and their immunophenotypes CD14++CD16-VEGFR2+, CD14++CD16+VEGFR2+, CD14+CD16++VEGFR2+, and CD14+CD16-VEGFR2+ was determined by flow cytometry. Using enzyme-linked immunosorbent assay, the levels of VЕGF-А, TNFα, M-CSF, and IL-13, as well as the content of MCP-1 (only in the blood) and the M-CSF / IL-13 ratio (only in the bone marrow) were determined.Results. The content of CD14+VEGFR2+ cells in the blood of CAD patients with and without ICM was higher than normal values due to the greater number of CD14++CD16-VEGFR2+, CD14++CD16+VEGFR2+, and CD14+CD16++VEGFR2+. In the bone marrow of the patients with ICM, the content of CD14++CD16-VEGFR2+, CD14+CD16++VEGFR2+, and CD14+CD16-VEGFR2+ was lower than in patients with CAD without ICM, and the number of CD14++CD16+VEGFR2+ cells corresponded to that in the controls. Regardless of the presence of ICM in CAD, a high concentration of TNFα and normal levels of VEGF-A and IL-13 were observed in the blood. In CAD without ICM, an excess of MCP-1 and deficiency of M-CSF were revealed in the blood. In the bone marrow, the levels of VEGF-A, TNFα, M-CSF, and IL-13 were comparable between the groups of patients against the background of a decrease in the M-CSF / IL-13 ratio in the patients with ICM.Conclusion. Unlike CAD without cardiomyopathy, in ICM, no excess of VEGFR2+ cells and MCP-1 in the blood is observed, which hinders active migration of CD14+CD16++VEGFR2+ cells from the myeloid tissue, and a decrease in the M-CSF / IL-13 ratio in the bone marrow disrupts differentiation of other forms of VEGFR2+ cells, preventing vascular repair.Цель: установить нарушения дифференцировки и субпопуляционного состава VEGFR2+ моноцитов в крови и костном мозге во взаимосвязи с особенностями цитокинового профиля крови и костного мозга у больных ишемической болезнью сердца (ИБС), страдающих и не страдающих ишемической кардиомиопатией (ИКМП).Материалы и методы. В исследование вошли 74 больных ИБС, страдающих и не страдающих ИКМП (30 и 44 человека соответственно), и 18 здоровых доноров. У всех больных ИБС забор периферической крови производился непосредственно перед операцией коронарного шунтирования, а костного мозга – из разреза грудины во время операции. У здоровых доноров забирали только периферическую кровь.  В костном мозге и крови методом проточной цитофлуориметрии определяли численность VEGFR2+ моноцитов (CD14+VЕGFR2+ клеток) и их иммунофенотипов CD14++CD16-VEGFR2+, CD14++CD16+VEGFR2+, CD14+CD16++VEGFR2+, CD14+CD16-VEGFR2+, методом иммуноферментного анализа регистрировали концентрацию VЕGF-А, TNFα, M-CSF, IL-13, а также содержание MCP-1 (только в крови) и соотношение M-CSF/IL-13 (только в костном мозге).Результаты. Содержание CD14+VEGFR2+ клеток в крови у больных ИБС без кардиомиопатии и с ИКМП было выше нормы из-за большей численности CD14++CD16-VEGFR2+, CD14++CD16+VEGFR2+ и CD14+CD16++VEGFR2+ форм. В костном мозге у больных ИКМП содержание CD14++CD16-VEGFR2+, CD14+CD16++VEGFR2+ и CD14+CD16-VEGFR2+ форм было ниже, чем у больных ИБС без кардиомиопатии, а количество CD14++CD16+VEGFR2+ клеток соответствовало их числу в группе сравнения. Вне зависимости от наличия ИКМП при ИБС в крови отмечалась высокая концентрация TNFα, нормальный уровень VEGF-А и IL-13; при ИБС без кардиомиопатии – избыток МСР-1 и дефицит M-CSF в крови. В костном мозге концентрация VЕGF-А, TNFα, M-CSF, IL-13 была сопоставимой между группами больных на фоне снижения M-CSF/IL-13 у пациентов с ИКМП.Заключение. В отличие от ИБС без кардиомиопатии при ИКМП не формируется избыток VEGFR2+ моноцитов и МСР-1 в крови, что затрудняет активную миграцию CD14+CD16++VEGFR2+ клеток из миелоидной ткани, а снижение M-CSF/IL-13 в костном мозге нарушает дифференцировку остальных форм VEGFR2+ моноцитов, препятствуя репарации сосудов

The Use of Sutureless Electrosurgical and Ultrasound Technologies in Lung Surgeries – Literature Review

На современном уровне развития видеоторакоскопической хирургии легких методом выбора является использование эндостеплеров (ЕС), осуществляющих одновременное прошивание и рассечение легочной ткани между наложенным рядом танталовых скобок. Однако широкое применение ЭС показало, что механический шов не всегда обеспечивает надежный аэростаз, что заставляет использовать дополнительные синтетические материалы. Кроме того, недостатками использования ЭС является их высокая цена, потребность в использовании нескольких картриджей, пострезекционное выключение из дыхания неизмененных участков легочной паренхимы, возможные трудности в размещении рабочей части аппарата в плевральной полости, большой диаметр торакопорта (Т), необходимый для введения ЭС.The review presents data of the use of electric seal and ultrasonic technology in the performance of open and videothoracoscopic lung resections. The possibility of seamless resection of the lung tissue by using bipolar electric seal (LigaSure) and ultrasonic (Harmonic) scalpel with tolerable aerohemostasis shown. The advantages and possible drawbacks of these methods displayed

Production of angiogenesis mediators and the structure of the vascular wall in the heart in ischemic cardiomyopathy

Background. In the pathogenesis of ischemic cardiomyopathy (ICMP), angiopoiesis remains unexplored.The aim. To describe the vasculature of the heart and the imbalance of angiogenesis mediators in the coronary circulation in association with the number of endothelial progenitor cells (EPC) and desquamated endothelial cells (DEC) in the blood of patients with coronary heart disease (CHD), suffering and not suffering from ICMP.Methods. Fifty-two patients with CHD (30  patients with ICMP, 22  patients without  ICMP), 15  healthy donors were examined. The content of EPC (CD14+CD34+VEGFR2+) in the blood from the cubital vein and DEC (CD45–CD146+) in the blood from the coronary sinus and the cubital vein was determined by flow cytometry. The concentrations of VEGF-A (vascular endothelial growth factor A), PDGF (platelet-derived growth factor), and SDF-1 (stromal cell-derived factor 1) in blood plasma were recorded using immunofluorescence assay; the angiopoietin-2, MMP-9 (matrix metallopeptidase 9) were recorded using enzyme immunoassay. In myocardial biopsies the specific area of vessels and the expression of αSMA (smooth muscle alpha-actin) were determined by morphometric and immunohistochemical methods.Results. In the peripheral blood of patients with CHD, regardless of the presence of ICMP, the DEC content exceeded the physiological level, and the VEGF-A, PDGF, angiopoietin-2, and MMP-9 corresponded to the norm. In CHD patients without cardiomyopathy, there was an excess of SDF-1 and EPC in the blood from the cubital vein, and in ICMP, their physiological significance was noted. In the coronary blood flow in patients with CHD without cardiomyopathy, an increase in the concentration of PDGF was found, which was not determined in patients with ICMP, who had an increased content of DEC, angiopoietin-2 and MMP-9. The specific area of the vessels in the patients of the two groups was comparable; the expression of αSMA in ICMP was 6.2 times lower than in patients with CHD without cardiomyopathy.Conclusion. The development of ICMP is accompanied by impaired maturation of vessels in the myocardium, associated with the absence of a compensatory reaction of activation of cellular and humoral factors of angiogenesis