The Data Processing Pipeline for the Herschel-HIFI Instrument

The HIFI data processing pipeline was developed to systematically process diagnostic, calibration and astronomical observations taken with the HIFI science instrumentas part of the Herschel mission. The HIFI pipeline processed data from all HIFI observing modes within the Herschel automated processing environment, as well as, within an interactive environment. A common software framework was developed to best support the use cases required by the instrument teams and by the general astronomers. The HIFI pipeline was built on top of that and was designed with a high degree of modularity. This modular design provided the necessary flexibility and extensibility to deal with the complexity of batch-processing eighteen different observing modes, to support the astronomers in the interactive analysis and to cope with adjustments necessary to improve the pipeline and the quality of the end-products. This approach to the software development and data processing effort was arrived at by coalescing the lessons learned from similar research based projects with the understanding that a degree of foresight was required given the overall length of the project. In this article, both the successes and challenges of the HIFI software development process are presented. To support future similar projects and retain experience gained lessons learned are extracted.Comment: 18 pages, 5 figure

The effect of combined renal and pancreatic transplantation on diabetic retinopathy

This case report describes the effect of simultaneous pancreas kidney transplant (SPK) on the diabetic retinopathy (DR) of two male type 1 diabetic patients. The literature on the effect of SPK on DR is reviewed and the evidence surrounding visual function outcomes is discussed

Maternal and child reflective functioning in the context of child sexual abuse: pathways to depression and externalising difficulties

BACKGROUND: Sexual abuse is a well-recognised risk factor for child psychopathology. Little is known regarding whether child and maternal mentalization can be considered a potential resource or protective factor in this context, respectively, mediating or moderating the relationship between sexual abuse and psychopathology. OBJECTIVE: The aims of this study were (1) to explore the relationships between child and maternal mentalizing, measured as reflective functioning (RF), and child depressive symptoms and externalising difficulties; and (2) to examine whether child mentalizing mediates the relationship between child sexual abuse (CSA) and psychopathology. METHOD: A total of 168 children aged 7-12 years and their mothers participated in the study. The sample included 74 dyads where children had experienced sexual abuse. The Child Attachment Interview was rated by using the Child Reflective Functioning Scale to assess children's mentalization, and the Child Depression Inventory was used to assess depressive symptoms. Mothers completed the Parent Development Interview to assess maternal RF and the Child Behavior Checklist to assess their child's externalising difficulties. A model involving direct and indirect paths from CSA, child and maternal RF to child psychopathology was examined using Mplus software. RESULTS: Child mentalization partially mediated the relationships between CSA and depressive symptoms, as well as the relationship between CSA and externalising difficulties. Maternal mentalization was an independent predictor of child externalising difficulties, with higher maternal RF associated with less externalising difficulties. DISCUSSION: The findings indicate that by ages 7-12, child mentalization is an important inner resource associated with lower depression and externalising. In addition, this study provides new evidence of the importance of the parent's mentalizing stance for the development of self-regulation and externalising difficulties in both abused and non-abused children. The clinical implications are discussed

Tunable Double Negative Band Structure from Non-Magnetic Coated Rods

A system of periodic poly-disperse coated nano-rods is considered. Both the coated nano-rods and host material are non-magnetic. The exterior nano-coating has a frequency dependent dielectric constant and the rod has a high dielectric constant. A negative effective magnetic permeability is generated near the Mie resonances of the rods while the coating generates a negative permittivity through a field resonance controlled by the plasma frequency of the coating and the geometry of the crystal. The explicit band structure for the system is calculated in the sub-wavelength limit. Tunable pass bands exhibiting negative group velocity are generated and correspond to simultaneously negative effective dielectric permittivity and magnetic permeability. These can be explicitly controlled by adjusting the distance between rods, the coating thickness, and rod diameters

Synthesis of 4,5-diazaspiro[2.3]hexanes and 1,2-diazaspiro[3.3]heptanes as hexahydropyridazine analogues

4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of readily accessible 3-alkylidene-1,2-diazetidines. Using difluorocarbene, generated from TMSCF3/NaI, these spirocycles were produced in yields up to 97% by stereospecific addition across the alkene. Lower yields (up to 64%) were observed using more reactive dichlorocarbene, due to competitive insertion of the carbene into the N–N bond. Larger 1,2-diazaspiro[3.3]heptanes are produced by [2+2] cycloaddition of 3-alkylidene-1,2-diazetidines with tetracyanoethylene (TCNE) in up to 99% yield. These additions work with di-, tri- and tetrasubstituted alkenes, offering a practical route to rigidified analogues of the medicinally important hexahydropyridazines

Managing bereavement in the classroom: a conspiracy of silence?

The ways in which teachers in British schools manage bereaved children are under-reported. This article reports the impact of students' bereavement and their subsequent management in primary and secondary school classrooms in Southeast London. Thirteen school staff working in inner-city schools took part in in-depth interviews that focused on the impact of bereaved children on the school and how teachers responded to these children. All respondents had previously had contact with a local child bereavement service that aims to provide support, advice, and consultancy to children, their parents, and teachers. Interviews were audiotaped, transcribed verbatim, and analyzed using ATLAS-ti. Three main themes were identified from analysis of interview data. Firstly, British society, culture, local communities, and the family were significant influences in these teachers' involvement with bereaved students. Secondly, school staff managed bereaved students through contact with other adults and using practical classroom measures such as "time out" cards and contact books. Lastly, teachers felt they had to be strong, even when they were distressed. Surprise was expressed at the mature reaction of secondary school students to deaths of others. The article recommends that future research needs to concentrate on finding the most effective way of supporting routinely bereaved children, their families, and teachers

ELVIS: Entertainment-led video summaries

© ACM, 2010. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version was published in ACM Transactions on Multimedia Computing, Communications, and Applications, 6(3): Article no. 17 (2010) http://doi.acm.org/10.1145/1823746.1823751Video summaries present the user with a condensed and succinct representation of the content of a video stream. Usually this is achieved by attaching degrees of importance to low-level image, audio and text features. However, video content elicits strong and measurable physiological responses in the user, which are potentially rich indicators of what video content is memorable to or emotionally engaging for an individual user. This article proposes a technique that exploits such physiological responses to a given video stream by a given user to produce Entertainment-Led VIdeo Summaries (ELVIS). ELVIS is made up of five analysis phases which correspond to the analyses of five physiological response measures: electro-dermal response (EDR), heart rate (HR), blood volume pulse (BVP), respiration rate (RR), and respiration amplitude (RA). Through these analyses, the temporal locations of the most entertaining video subsegments, as they occur within the video stream as a whole, are automatically identified. The effectiveness of the ELVIS technique is verified through a statistical analysis of data collected during a set of user trials. Our results show that ELVIS is more consistent than RANDOM, EDR, HR, BVP, RR and RA selections in identifying the most entertaining video subsegments for content in the comedy, horror/comedy, and horror genres. Subjective user reports also reveal that ELVIS video summaries are comparatively easy to understand, enjoyable, and informative

Population Sizing for the Redundant Trivial Voting Mapping

Mapping-Proble

The need for a marker predicting benefit following cardiovascular disease risk reduction treatment

Developing a robust method to study characteristics of vascular flow using ultrasound may be useful to assess endothelial function and vasodilatation. There are four stages in this proposal. 1.The first stage is to standardise and validate the methodology to enable computational risk flow data and other flow characteristics to be used clinically. (Current Study). Further development of fluid modelling methods will enable particulate haemodynamics to be investigated, and incorporate detailed endothelial structure together with cellular pathways. 2. This should be followed up by studies in different patient groups investigating the association between the derived values and estimated risk (using other methods such as Framingham risk score). 3. Then, associated with underlying cardiovascular risk, prospective studies would be made to establish whether computational flow dynamic data can predict outcome. If successful it could prove to be a very useful marker of benefit following treatment in a clinical setting

Massive Stars in the Quintuplet Cluster

We present near-infrared photometry and K-band spectra of newly-identified massive stars in the Quintuplet Cluster, one of the three massive clusters projected within 50 pc of the Galactic Center. We find that the cluster contains a variety of massive stars, including more unambiguously identified Wolf-Rayet stars than any cluster in the Galaxy, and over a dozen stars in earlier stages of evolution, i.e., LBV, Ofpe/WN9, and OB supergiants. One newly identified star is the second ``Luminous Blue Variable'' in the cluster, after the ``Pistol Star.'' Given the evolutionary stages of the identified stars, the cluster appears to be about 4 \pm 1 Myr old, assuming coeval formation. The total mass in observed stars is \sim 10^3 \Msun, and the implied mass is \sim 10^4 \Msun, assuming a lower mass cutoff of 1 \Msun and a Salpeter initial mass function. The implied mass density in stars is at least a few thousand \Msun pc^{-3}. The newly-identified stars increase the estimated ionizing flux from this cluster by about an order of magnitude with respect to earlier estimates, to 10^{50.9} photons/s, or roughly what is required to ionize the nearby ``Sickle'' HII region (G0.18 - 0.04). The total luminosity from the massive cluster stars is $\approx 10^{7.5}$ \Lsun, enough to account for the heating of the nearby molecular cloud, M0.20 - 0.033. We propose a picture which integrates most of the major features in this part of the sky, excepting the non-thermal filaments. We compare the cluster to other young massive clusters and globular clusters, finding that it is unique in stellar content and age, except, perhaps, for the young cluster in the central parsec of the Galaxy. In addition, we find that the cluster is comparable to small ``super star clusters.'