Determination of the Efficacy of Fertilization Practices on Bob Kidd Lake

Fertilization strategies have been used as a standard practice on Bob Kidd and other lakes and reservoirs to enhance the availability of phytoplankton and zooplankton as food sources for developing fish. The nominal practice is to use a fixed application rate and a constant ratio of nitrogen and phosphorus fertilizer per acre of lake surface. The application technique varies as does the timing. Application techniques vary from spillage and bulk deposition of fertilizer at selected sites to broadcasting of pellets or a pre-mixed slurry via boat and/or airplane. Timing is usually in the spring under appropriate weather conditions

Stray Current Corrosion Due to Utility Cathodic Protection

The conditions in which stray currents contribute to the corrosion damage of highway structures, the tests to determine if these conditions exist, and the methods recommended to alleviate either the conditions or the damage caused by stray current corrosion are investigated. An extensive review of the literature concerning the fundamentals of stray current corrosion and the practices of utility cathodic protection is presented, including a comprehensive study of the history of stray current corrosion, from its conception with the direct current trolley systems of the late 1880's to its present day problems in the cathodic protection industry. Federal, state, and Kansas Department of Transportation rules and policy are reviewed as they pertain to utility cathodic protection and the damage it may cause to adjacent underground highway structures. Based on the research covered within this report, procedural changes for the prevention of stray current corrosion damage to highway structures and additions to the KDOT Utility Accommodation Policy (1994) are recommended. The research herein concludes that: (1) that all construction close to cathodically protected utilities should be reported to the utility owners so that stray current interference can be assessed, (2) any utility pipeline found uncovered should be reported to its owner so that it can be inspected for corrosion damage, and (3) no underground highway structure should be located within the area of influence of a cathodic protection groundbed. Additionally, its recommended that the KDOT Utility Accommodation Policy (1994) be modified to: (I) directly state the policy on stray current interference from utility cathodic protection systems, (2) require utilities installing cathodic protection systems to submit the design plans as part of the process necessary to obtain a permit agreement for operating in a highway right-of-way, and (3) state that KDOT may require additional inspections along pipelines where interference could jeopardize the structural integrity of an underground highway structure

Spinal cord stimulation for predominant low back pain in failed back surgery syndrome: study protocol for an international multicenter randomized controlled trial (PROMISE study)

Background: Although results of case series support the use of spinal cord stimulation in failed back surgery syndrome patients with predominant low back pain, no confirmatory randomized controlled trial has been undertaken in this patient group to date. PROMISE is a multicenter, prospective, randomized, open-label, parallel-group study designed to compare the clinical effectiveness of spinal cord stimulation plus optimal medical management with optimal medical management alone in patients with failed back surgery syndrome and predominant low back pain. Method/Design: Patients will be recruited in approximately 30 centers across Canada, Europe, and the United States. Eligible patients with low back pain exceeding leg pain and an average Numeric Pain Rating Scale score >= 5 for low back pain will be randomized 1:1 to spinal cord stimulation plus optimal medical management or to optimal medical management alone. The investigators will tailor individual optimal medical management treatment plans to their patients. Excluded from study treatments are intrathecal drug delivery, peripheral nerve stimulation, back surgery related to the original back pain complaint, and experimental therapies. Patients randomized to the spinal cord stimulation group will undergo trial stimulation, and if they achieve adequate low back pain relief a neurostimulation system using the Specify (R) 5-6-5 multi-column lead (Medtronic Inc., Minneapolis, MN, USA) will be implanted to capture low back pain preferentially in these patients. Outcome assessment will occur at baseline (pre-randomization) and at 1, 3, 6, 9, 12, 18, and 24 months post randomization. After the 6-month visit, patients can change treatment to that received by the other randomized group. The primary outcome is the proportion of patients with >= 50% reduction in low back pain at the 6-month visit. Additional outcomes include changes in low back and leg pain, functional disability, health-related quality of life, return to work, healthcare utilization including medication usage, and patient satisfaction. Data on adverse events will be collected. The primary analysis will follow the intention-to-treat principle. Healthcare use data will be used to assess costs and long-term cost-effectiveness. Discussion: Recruitment began in January 2013 and will continue until 2016

Cost-Effectiveness Model Shows Superiority of Wireless Spinal Cord Stimulation Implantation Without a Separate Trial.

OBJECTIVE: We evaluated the cost-effectiveness of wireless spinal cord stimulation (Wireless SCS) with single stage direct to permanent implantation vs. screening with temporary electrodes and an external pulse generator followed by implantation of a system for long-term use (IPG SCS). MATERIALS AND METHODS: We created a cost model that takes a 2019 United States (U.S.) payer perspective and is based on IPG SCS cost models for subjects with chronic back and/or leg pain. Our six-month decision tree includes the screening trial period (success ≥50% relief) and leads to various levels of pain relief with or without complications for IPG SCS and Wireless SCS and without complications for conventional medical management (CMM). Every three months in the follow-on 15-year Markov model (with costs and quality-adjusted life years discounted 3.5% annually), subjects remain stable or transition to deteriorated health or death. Subjects who fail SCS receive CMM. After 60 Markov cycles, a 100,000-sample simulation reveals the impact of maximum willingness-to-pay (WTP) from $10,000 to$100,000 per quality-adjusted life year on net monetary benefit (NMB). Sensitivity analyses considered the impact of the Wireless SCS screening success rate, Wireless SCS device cost, and IPG SCS device longevity. RESULTS: Compared with IPG SCS, Wireless SCS offers higher clinical effectiveness at a lower cost and a higher NMB for our WTP thresholds and is, thus, dominant. Wireless SCS is also cost-effective compared with CMM. Results remain robust with 1) Wireless SCS screening success rates as low as 85% (dominant), 2) the cost of the Wireless SCS devices as high as $55,000 (cost-effective), and 3) IPG SCS devices lasting 12 years (dominant). CONCLUSIONS: In this model, compared with IPG SCS or with CMM, Wireless SCS is a superior strategy

Clinical Trypanosoma cruzi Disease after Cardiac Transplantation in a Cynomolgus Macaque (Macaca fascicularis)

A cynomolgus macaque received a heterotopic cardiac allograft as part of a transplant study, with monoclonal antibodies targeted to specific immune costimulation molecules (CD154, CD28) but no traditional immunosuppressive therapy after surgery. Clinical anemia was detected on postoperative day (POD) 35 and had worsened (Hgb, 2.3 g/dL; Hct = 7.3%) by POD 47, despite type-matched whole-blood transfusions. After a total of 4 blood transfusions, hematologic parameters were improved (Hgb, 5.9 g/dL; Hct, 18.7%). On POD 50, a peripheral blood smear revealed trypomastigotes, and qualitative RT-PCR of whole blood identified the organism as Trypanosoma cruzi. Although clinically stable initially, the macaque soon developed sufficient weight loss to necessitate euthanasia on POD 64. The final diagnosis was clinical anemia due to T. cruzi infection. This study represents the first reported case of Chagas disease after heart transplant in a NHP

Areal Distribution, Thickness, Mass, Volume, and Grain Size of Air-Fall Ash from the Six Major Eruptions of 1980

The airborne-ash plume front from the Mount St. Helens eruption of May 18 advanced rapidly to the northeast at an average velocity of about 250 km/hr during the first 13 min after eruption. It then traveled to the east-northeast within a high-velocity wind layer at altitudes of 10-13 km at an average velocity of about 100 km/hr over the first 1,000 km. Beyond about 60 km, the thickest ash fall was east of the volcano in Washington, northern Idaho, and western Montana. A distal thickness maximum near Ritzville, Wash., is due to a combination of factors: (1) crude sorting within the vertical eruptive column, (2) eruption of finer ash above the high-velocity wind layer at altitudes of 10-13 km, and (3) settling of ash through and below that layer. Isopach maps for the May 25, June 12, August 7, and October 16-18 eruptions show distal thickness maximums similar to that of May 18. A four-unit tephra stratigraphy formed by the May 18 air fall within proximal areas east of the volcano changes to three units, two units, and one unit at progressively greater distances downwind. Much of the deposits beyond 200 km from the volcano has two units. A lower thin dark lithic ash is inferred to represent products that disintegrated from the volcano\u27s summit in the initial part of the eruption and early juvenile pumice and glass. An upper, thicker, light-gray ash rich in pumice and volcanic-glass shards represents the later voluminous eruption of juvenile magma. The axis of the dark-ash lobe in eastern Washington and norther Idaho is south of the axis of the light-gray ash lobe because the high-velocity wind layer shifted northward during the eruption. The areal distribution of ash on the ground is offset to the north relative to the mapped position of the airborne-ash plume, because the winds below the high-velocity wind layer were more northward. Except for the distal thickness near Ritzville, Wash., mass per area, thickness, and bulk density of the May 18 ash decrease downwind, because larger grains and heavier lithic and crystal grains settled out closer to the volcano than did the lighter pumice and glass shards. A minimum volume of 1.1 km3 of uncompacted tephra is estimated for the May 18 eruption; this volume is equivalent to about 0.20-0.25 km3 of solid rock, assuming an average density of between 2.0 and 2.6 g/cm3 for magma and summit rocks. The estimated total mass from the May 18 eruption is 4.9 x 1014 g, and the average uncompacted bulk density for downwind ash is 0.45 g/cm3. Masses and volumes for the May 24 and June 12 eruptions are an order of magnitude smaller than those of May 18, but average bulk densities are higher (about 1.00 and 1.25), owing to compaction by rain that fell during or shortly after the two eruptions. Volume and mass of the July 22 eruption are two orders of magnitude smaller than those of May 18, and those of the August 7 and October 16-18 eruptions are three orders of magnitude smaller. The eruption of May 18, however, is smaller than five of the last major eruptions of Mount St. Helens in terms of volume of air-fall tephra produced, but probably is intermediate if the directed-blast deposit is included with the air-fall tephra

Schizophrenia, narcolepsy, and HLA-DR15, DQ6

A strong association between HLA-DR2, DQ1 and narcolepsy-cataplexy has been known since 1986. In 1990 a subdivision (HLA-DR15, DQ6) was shown to be equally associated. Narcolepsy symptoms include rapid eye movement (REM)-sleep intrusion hallucinations during the day. Some narcoleptics may be so hallucinated that they become delusional and receive a diagnosis of schizophrenia. Fifty-six inpatient schizophrenics and 56 normal controls were compared to see if there was an excess of the narcolepsy-associated antigens (NAA) among schizophrenics. Patients had frequency of the NAA 3.89 times higher than controls. After a subset was studied by night (n = 9) and day (n = 7) polysomnography, two patients were found to be true narcoleptics. Their psychosis improved with treatment for narcolepsy. When NAA(+) and NAA(-) schizophrenics were compared, the NAA(+) subgroup had significantly higher Brief Psychiatric Rating Scale (BPRS) scores and more hospitalizations. There were no effects attributable only to gender or race. We conclude that narcolepsy can simulate schizophrenia in some cases, and that even in nonnarcoleptic patients, the HLA-DR15, DQ6 antigens mark a group of severe schizophrenics that merits further study.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30431/1/0000052.pd