95 research outputs found

    Social presence and dishonesty in retail

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    Self-service checkouts (SCOs) in retail can benefit consumers and retailers, providing control and autonomy to shoppers independent from staff, together with reduced queuing times. Recent research indicates that the absence of staff may provide the opportunity for consumers to behave dishonestly, consistent with a perceived lack of social presence. This study examined whether a social presence in the form of various instantiations of embodied, visual, humanlike SCO interface agents had an effect on opportunistic behaviour. Using a simulated SCO scenario, participants experienced various dilemmas in which they could financially benefit themselves undeservedly. We hypothesised that a humanlike social presence integrated within the checkout screen would receive more attention and result in fewer instances of dishonesty compared to a less humanlike agent. This was partially supported by the results. The findings contribute to the theoretical framework in social presence research. We concluded that companies adopting self-service technology may consider the implementation of social presence in technology applications to support ethical consumer behaviour, but that more research is required to explore the mixed findings in the current study.<br/

    Both Strands of siRNA Have Potential to Guide Posttranscriptional Gene Silencing in Mammalian Cells

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    Despite the widespread application of RNA interference (RNAi) as a research tool for diverse purposes, the key step of strand selection of siRNAs during the formation of RNA-induced silencing complex (RISC) remains poorly understood. Here, using siRNAs targeted to the complementary region of Survivin and the effector protease receptor 1 (EPR-1), we show that both strands of the siRNA duplex can find their target mRNA and are equally eligible for assembly into Argonaute 2 (Ago2) of RISC in HEK293 cells. Transfection of the synthetic siRNA duplexes with different thermodynamic profiles or short hairpin RNA (shRNA) vectors that generate double-stranded RNAs (dsRNAs), permitting processing specifically from either the 5′ or 3′ end of the incipient siRNA, results in the degradation of the respective target mRNAs of either strand of the siRNA duplex with comparable efficiencies. Thus, while most RNAi reactions may follow the thermodynamic asymmetry rule in strand selection, our study suggests an exceptional mode for certain siRNAs in which both strands of the duplex are competent in sponsoring RNAi, and implies additional factors that might dictate the RNAi targets

    Generation of cell type-specific monoclonal antibodies for the planarian and optimization of sample processing for immunolabeling

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    Organization Size and the Optimal Investment in Cash

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    This article was published in the journal, IMA Journal of Management Mathematics: imaman.oxfordjournals.org/Miller & Orr (1966, Q. J. Econ., 80, 413–435) formulate a cash management model under which an organization’s cash flow evolves in terms of a stationary random walk. This, in turn, implies that the organization’s demand for cash will not grow over time. However, as organizations grow one would expect the demand for cash to grow as well. Given this, we formulate a cash management model under which movements in an organization’s cash balance hinge on its current rate of output or an equivalent size measure. Cash is withdrawn and invested in interest-bearing securities when the cash to output ratio becomes too high, while securities are sold and the proceeds deposited in a non-interest-bearing bank account when the cash to output ratio becomes too low. The control limits are determined so as to minimize the expected annual cost of a unit of output. Our analysis shows that when organization’s cash flows follow a non-stationary process, the optimal cash management policies are profoundly different to those obtained under the Miller & Orr (1966) model
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