676 research outputs found
Sub-Alfvenic Non-Ideal MHD Turbulence Simulations with Ambipolar Diffusion: I. Turbulence Statistics
Most numerical investigations on the role of magnetic fields in turbulent
molecular clouds (MCs) are based on ideal magneto-hydrodynamics (MHD). However,
MCs are weakly ionized, so that the time scale required for the magnetic field
to diffuse through the neutral component of the plasma by ambipolar diffusion
(AD) can be comparable to the dynamical time scale. We have performed a series
of 256^3 and 512^3 simulations on supersonic but sub-Alfvenic turbulent systems
with AD using the Heavy-Ion Approximation developed in Li, McKee, & Klein
(2006). Our calculations are based on the assumption that the number of ions is
conserved, but we show that these results approximately apply to the case of
time-dependent ionization in molecular clouds as well. Convergence studies
allow us to determine the optimal value of the ionization mass fraction when
using the heavy-ion approximation for low Mach number, sub-Alfvenic turbulent
systems. We find that ambipolar diffusion steepens the velocity and magnetic
power spectra compared to the ideal MHD case. Changes in the density PDF, total
magnetic energy, and ionization fraction are determined as a function of the AD
Reynolds number. The power spectra for the neutral gas properties of a strongly
magnetized medium with a low AD Reynolds number are similar to those for a
weakly magnetized medium; in particular, the power spectrum of the neutral
velocity is close to that for Burgers turbulence.Comment: 37 pages, 11 figures, 4 table
Evaluating quasilocal energy and solving optimal embedding equation at null infinity
We study the limit of quasilocal energy defined in [7] and [8] for a family
of spacelike 2-surfaces approaching null infinity of an asymptotically flat
spacetime. It is shown that Lorentzian symmetry is recovered and an
energy-momentum 4-vector is obtained. In particular, the result is consistent
with the Bondi-Sachs energy-momentum at a retarded time. The quasilocal mass in
[7] and [8] is defined by minimizing quasilocal energy among admissible
isometric embeddings and observers. The solvability of the Euler-Lagrange
equation for this variational problem is also discussed in both the
asymptotically flat and asymptotically null cases. Assuming analyticity, the
equation can be solved and the solution is locally minimizing in all orders. In
particular, this produces an optimal reference hypersurface in the Minkowski
space for the spatial or null exterior region of an asymptotically flat
spacetime.Comment: 22 page
The management of ocular allergy in community pharmacies in the United Kingdom
Background Ocular allergies frequently present in pharmacy practices. However, research into the actual management of ocular allergy in pharmacies is lacking. Objective To determine and quantify history and symptom questioning of a patient with presumed allergic conjunctivitis and management strategies employed by pharmacy staff in the UK. Method A mystery shopper technique was used to simulate an episode of allergic conjunctivitis in 100 community pharmacies across the UK. Results The mean number of questions asked by pharmacy staff to the patient was 3.5 ± 2.6, with a range of 0-10. The most common question was whether the patient had a history of allergies (45 %).Ninety-one percent advised on treatment, with the remaining 9 % directly referring to the patient's general practitioner (n = 4) or pharmacist(n = 4), but only two to their optometrist. The most common treatment suggested was sodium cromoglycate 2 % (50 %). However, many pharmacies advising treatment did not ask the patient's age (37 %), if they wore contact lenses (43 %), or gave dosage advice (43 %). Only 5 % of pharmacies advised follow up and 14 % suggested visiting a general practitioner and 1 % an optometrist if symptoms did not resolve with treatment. Conclusion There is a need for improved ophthalmological training for pharmacy staff with respect to the management of allergic conjunctivitis. © Springer Science+Business Media Dordrecht 2012
A targeted gene panel that covers coding, non-coding and short tandem repeat regions improves the diagnosis of patients with neurodegenerative diseases
Genetic testing for neurodegenerative diseases (NDs) is highly challenging because of genetic heterogeneity and overlapping manifestations. Targeted-gene panels (TGPs), coupled with next-generation sequencing (NGS), can facilitate the profiling of a large repertoire of ND-related genes. Due to the technical limitations inherent in NGS and TGPs, short tandem repeat (STR) variations are often ignored. However, STR expansions are known to cause such NDs as Huntington\u27s disease and spinocerebellar ataxias type 3 (SCA3). Here, we studied the clinical utility of a custom-made TGP that targets 199 NDs and 311 ND-associated genes on 118 undiagnosed patients. At least one known or likely pathogenic variation was found in 54 patients; 27 patients demonstrated clinical profiles that matched the variants; and 16 patients whose original diagnosis were refined. A high concordance of variant calling were observed when comparing the results from TGP and whole-exome sequencing of four patients. Our in-house STR detection algorithm has reached a specificity of 0.88 and a sensitivity of 0.82 in our SCA3 cohort. This study also uncovered a trove of novel and recurrent variants that may enrich the repertoire of ND-related genetic markers. We propose that a combined comprehensive TGPs-bioinformatics pipeline can improve the clinical diagnosis of NDs
Geometric Aspects of the Moduli Space of Riemann Surfaces
This is a survey of our recent results on the geometry of moduli spaces and
Teichmuller spaces of Riemann surfaces appeared in math.DG/0403068 and
math.DG/0409220. We introduce new metrics on the moduli and the Teichmuller
spaces of Riemann surfaces with very good properties, study their curvatures
and boundary behaviors in great detail. Based on the careful analysis of these
new metrics, we have a good understanding of the Kahler-Einstein metric from
which we prove that the logarithmic cotangent bundle of the moduli space is
stable. Another corolary is a proof of the equivalences of all of the known
classical complete metrics to the new metrics, in particular Yau's conjectures
in the early 80s on the equivalences of the Kahler-Einstein metric to the
Teichmuller and the Bergman metric.Comment: Survey article of our recent results on the subject. Typoes
corrrecte
Trust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood
Childhood sexual abuse (CSA) has been shown to predict the coupling of depression and inflammation in adulthood. Trust within intimate relationships, a core element in marital relations, has been shown to predict positive physical and mental health outcomes, but the mediating role of trust in partners in the association between CSA and inflammation in adulthood requires further study. The present study aimed to examine the impact of CSA on inflammatory biomarkers (IL-6 and IL-1β) in adults with depression and the mediating role of trust. A cross-sectional survey data set of adults presenting with mood and sleep disturbance was used in the analysis. CSA demonstrated a significant negative correlation with IL-6 level (r = -0.28, p<0. 01) in adults with clinically significant depression, while trust showed a significant positive correlation with IL-6 level (r = 0.36, p < .01). Sobel test and bootstrapping revealed a significant mediating role for trust between CSA and IL-6 level. CSA and trust in partners were revealed to have significant associations with IL-6 level in adulthood. Counterintuitively, the directions of association were not those expected. Trust played a mediating role between CSA and adulthood levels of IL-6. Plausible explanations for these counterintuitive findings are discussed
Nonlinear and conventional biosignal analyses applied to tilt table test for evaluating autonomic nervous system and autoregulation
Copyright © Tseng et al.; Licensee Bentham Open.
This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/
by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.Tilt table test (TTT) is a standard examination for patients with suspected autonomic nervous system (ANS) dysfunction or uncertain causes of syncope. Currently, the analytical method based on blood pressure (BP) or heart rate (HR) changes during the TTT is linear but normal physiological modulations of BP and HR are thought to be predominately nonlinear. Therefore, this study consists of two parts: the first part is analyzing the HR during TTT which is compared to three methods to distinguish normal controls and subjects with ANS dysfunction. The first method is power spectrum density (PSD), while the second method is detrended fluctuation analysis (DFA), and the third method is multiscale entropy (MSE) to calculate the complexity of system. The second part of the study is to analyze BP and cerebral blood flow velocity (CBFV) changes during TTT. Two measures were used to compare the results, namely correlation coefficient analysis (nMxa) and MSE. The first part of this study has concluded that the ratio of the low frequency power to total power of PSD, and MSE methods are better than DFA to distinguish the difference between normal controls and patients groups. While in the second part, the nMxa of the three stages moving average window is better than the nMxa with all three stages together. Furthermore the analysis of BP data using MSE is better than CBFV data.The Stroke Center and Department of Neurology, National Taiwan University, National Science Council in Taiwan, and the Center for Dynamical Biomarkers
and Translational Medicine, National Central University, which is sponsored by National Science Council and Min-Sheng General Hospital Taoyuan
Nanoantennas for visible and infrared radiation
Nanoantennas for visible and infrared radiation can strongly enhance the
interaction of light with nanoscale matter by their ability to efficiently link
propagating and spatially localized optical fields. This ability unlocks an
enormous potential for applications ranging from nanoscale optical microscopy
and spectroscopy over solar energy conversion, integrated optical
nanocircuitry, opto-electronics and density-ofstates engineering to
ultra-sensing as well as enhancement of optical nonlinearities. Here we review
the current understanding of optical antennas based on the background of both
well-developed radiowave antenna engineering and the emerging field of
plasmonics. In particular, we address the plasmonic behavior that emerges due
to the very high optical frequencies involved and the limitations in the choice
of antenna materials and geometrical parameters imposed by nanofabrication.
Finally, we give a brief account of the current status of the field and the
major established and emerging lines of investigation in this vivid area of
research.Comment: Review article with 76 pages, 21 figure
Atomic-scale confinement of optical fields
In the presence of matter there is no fundamental limit preventing
confinement of visible light even down to atomic scales. Achieving such
confinement and the corresponding intensity enhancement inevitably requires
simultaneous control over atomic-scale details of material structures and over
the optical modes that such structures support. By means of self-assembly we
have obtained side-by-side aligned gold nanorod dimers with robust
atomically-defined gaps reaching below 0.5 nm. The existence of
atomically-confined light fields in these gaps is demonstrated by observing
extreme Coulomb splitting of corresponding symmetric and anti-symmetric dimer
eigenmodes of more than 800 meV in white-light scattering experiments. Our
results open new perspectives for atomically-resolved spectroscopic imaging,
deeply nonlinear optics, ultra-sensing, cavity optomechanics as well as for the
realization of novel quantum-optical devices
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