SOLID LIPID NANOPARTICLES: A PROMISING APPROACH FOR COMBINATIONAL DRUG THERAPY IN CANCER

Combination therapy for cancer treatment is accepted worldwide due to the generation of synergistic anticancer effects; restrain in multidrug resistance (MDR) or tumor resistance by different mechanisms of action and minimization of dose-dependent toxicity. Recently developed Solid lipid nanoparticles (SLNs) are matrix composed of lipid which is solid at both room and body temperature and hence it is as an alternative to other nanocarrier systems. SLNs after oral administration get absorbed by lymphatic pathway due to stimulation of chylomicron formation. Thus, it avoids all consequences related to an oral drug delivery system and improves oral bioavailability. SLNs based combination drug delivery to tumor tissues reduces the problems associated with chemotherapy. The targeted and sustained delivery of chemotherapeutic agents reduces the dose by achieving high concentrations at the target site, without altering the normal tissues. In this article, we have reviewed and focused on SLNs as a drug delivery system; ingredients used in formulating SLNs and developed two or more drugs in a single formulation of SLNs as drug delivery. This article also focuses on the fact that SLNs as a combination drug delivery provides an attractive approach in future prevention and beneficial for the treatment of cancer by increasing its therapeutic efficacy

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF THREE-COMPONENT IN TABLET DOSAGE FORMULATION

ABSTRACT:An accurate, simple, reproducible andsensitive method for the determination ofparacetamol, caffeine and chlorpheniraminemaleate in tablet dosage form is developed andvalidated. The separation is achieved usingHiQsilC18HS reverse-phase column (250 X 4.6mm I.D., particle size 5μm) using a mixture ofacetonitrile and water in the proportion 55:300with final pH of 2.4 adjusted with o-phosphoricacid as a mobile phase. The flow rate is 1.0mL/ min and effluents were monitored at 265nm. Total run time is less than 12 min. andretention time of paracetamol, caffeine andchlorpheniramine maleate are 6.742, 9.417, and3.683 min respectively. Validation of method isdone as per ICH guideline for accuracy,precision, linearity, specificity, and sensitivity.The linearity for paracetamol is found to be100-650 μg/mL where as for caffeine andchlorpheniramine maleate is found in the rangeof 15-100 μg/mL. Result of validation study isfound statistically significant because all thestatistical parameters were within theacceptance range (COV and S.D. <1.0 for bothaccuracy and precision). The limits of detection(LOD) values are 1.2014, 0.4587 and 0.8945and limit of quantitation (LOQ) values are0.5142, 0.4512 and 0.7845 μg/mL forparacetamol, caffeine and chlorpheniraminemaleate respectively. High percentage recoveryand low COV value revealed the reliability ofthe method for quantitative study of threedrugs in Fevril tablets as a quality-control toolfor routine quantitative determination ofparacetamol, caffeine and chlorpheniraminemaleate

Survey Paper on Multi Keyword Similarity Search over Encrypted Cloud Data

The tremendous amount of data outsourced every day by individuals or each enterprises . It is impossible to manage or to store this complex data at individual level, as the chances of crash the system is more, and the system becomes the single point of failure.When we feel the need of storing the data in such a way that it can be accessed uninterruptedly, then there the cloud comes into picture to store the data with better flexibility and cost saving. As the data might be confidential or sensitive. Considering the privacy of the data over the cloud, for that searchable encryption can be used. At the time of retrieval of data, consider the multi-keyword search over outsourced cloud text data only as it can handle the exact keywork matching. Multi-keyword similarity search overcomes the problem of not finding any related documents on searching. while encrypting the data before storing it to the cloud will help to preserve the privacy of the files. Searchable encryption also enables searching without revealing any additional information. Using multi-keyword similarity search cloud returns the files containing more number of matches with user input keywords and similar keyworks. Finding the similarities between input keyword or similar keyword is done by edit distance metric algorithm. Final design to achieve the user privacy, and to speedup the search task. At cloud side Bloom Filter’s bit pattern is used to speedup and it is efficient in terms of the search time at the cloud side. This paper presents a review on various existing Similarity searching techniques

SMART AUTOMATIC BRAKING WITH PNEUMATIC BUMPER

The aim is to design and develop a control system based on a smart controlled automatic bumper activation system called “Smart Braking With Active Pneumatic bumper”. This system consists of IR Transmitter and Receiver , control unit , pneumatic bumper and Braking unit .In which the IR sensor senses the obstacle .If there is any obstacle closer to vehicle ,the control unit gives signal to bumper and brake activation system , due to this the brake and actuation of bumper acts simultaneously . This system acts only when the vehicle speed is beyond 40 km/hr. This system is an innovative project for the purpose of preventing accidents on road ways . This system improves the response time of vehicle braking to keep safe distance between two vehicles

Postdoctoral Fellowship 2014-2015/Carnegie Mellon University

Postdoctoral Fellowship/African American Urban: Postdoctoral Fellow, Center for Africanamerican Urban Studies and the Economy (CAUSE). The Department of History at Carnegie Mellon University seeks a scholar in the humanities and/or social sciences doing history-related research in African American urban studies. The appointment is for nine months beginning August 18, 2014. The fellowship carries a stipend of $50,000, and$5,000 for research, benefits and other expenses. The fellow will pursue..

Nontraumatic subperiosteal orbital hemorrhage following upper gastrointestinal endoscopy

Subperiosteal hemorrhages are typically the result of blunt orbital or facial trauma. Nontraumatic subperiosteal hemorrhages are uncommon and are usually attributed to increase in central venous pressure and bleeding disorders. Here, we report the case of a 38-year-old female who underwent an upper gastrointestinal (GI) endoscopy and developed bilateral nontraumatic subperiosteal hemorrhages that resolved with conservative treatment. Here, we discuss the source of bleeding and the mechanisms for the occurrence of orbital subperiosteal bleeds. GI surgeons and ophthalmologists should be sensitive to the possibility that orbital hemorrhage that can occur following endoscopy, especially when retching or gagging occurs during the procedure

Electrochemical Investigations of Double Perovskite M₂NiMnO₆ (Where M = Eu, Gd, Tb) for High-Performance Oxygen Evolution Reaction

Double perovskites are known for their special structures which can be utilized as catalyst electrode materials for electrochemical water splitting to generate carbon-neutral hydrogen energy. In this work, we prepared lanthanide series metal-doped double perovskites at the M site such as M2NiMnO6 (where M = Eu, Gd, Tb) using the solid-state reaction method, and they were investigated for an oxygen evolution reaction (OER) study in an alkaline medium. It is revealed that the catalyst with a configuration of Tb2NiMnO6 has outstanding OER properties such as a low overpotential of 288 mV to achieve a current density of 10 mAcm−2, a lower Tafel slope of 38.76 mVdec−1, and a long cycling stability over 100 h of continuous operation. A-site doping causes an alteration in the oxidation or valence states of the NiMn cations, their porosity, and the oxygen vacancies. This is evidenced in terms of the Mn4+/Mn3+ ratio modifying electronic properties and the surface which facilitates the OER properties of the catalyst. This is discussed using electrochemical impedance spectroscopy (EIS) and electrochemical surface area (ECSA) of the catalysts. The proposed work is promising for the synthesis and utilization of future catalyst electrodes for high-performance electrochemical water splitting

Actinomycetes canaliculitis complicating congenital nasolacrimal duct obstruction in an infant

Actinomyces israelii is a Gram-positive anaerobic organism commonly associated with canaliculitis in adults. Pediatric canaliculitis is relatively rare, especially in infancy. We report the case of an 11-month-old boy who presented with co-existing canaliculitis and congenital nasolacrimal obstruction. The presenting signs included epiphora, discharge, conjunctival congestion, and matting of lashes. On examination, punctual pouting, regurgitation, and yellow canaliculiths were noted. A punctoplasty and canalicular curettage were performed along with nasolacrimal probing. Microbiological tests confirmed the organisms to be A. israelii. We discuss the clinical features and management of Actinomyces-associated canaliculitis and review the available literature on pediatric canaliculitis