Postdoctoral Fellowship/African American Urban: Postdoctoral Fellow, Center for Africanamerican Urban Studies and the Economy (CAUSE). The Department of History at Carnegie Mellon University seeks a scholar in the humanities and/or social sciences doing history-related research in African American urban studies. The appointment is for nine months beginning August 18, 2014. The fellowship carries a stipend of $50,000, and $5,000 for research, benefits and other expenses. The fellow will pursue..

I, Disouza J

Pranit, Atpadikar

S, Amol Shete

shinde, sunita sakharam

V, Patil Manisha

irhis

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Postdoctoral Fellowship 2014-2015/Carnegie Mellon University

The basic objectives of this study were to prepare and characterize solid dispersions of poorly water-soluble drug fluconazole using hydrophilic carriers by spray drying technique. In the present study, a spray drying technique has been used to prepare solid dispersions with hydrophilic carriers, mainly  PVP K30and porous carrier Aerosil 200 are used Solid dispersions in the form of spray dried powder were characterized in comparison with pure drug and corresponding physical mixtures in the same ratios by SEM, IR, DSC, and XRPD studies. The absence of fluconazole peaks in XRPD profiles of solid dispersions suggests the transformation of crystalline fluconazole into an amorphous form.  the absence of fluconazole peak in DSC curves of solid dispersions. The DRIFTS spectra revealed the presence of hydrogen bonding in solid dispersions. The in vitro dissolution test showed a significant increase in the dissolution rate of solid dispersions as compared with pure fluconazole, spray-dried fluconazole, and physical mixtures of drug with hydrophilic carriers. It may be concluded that solid dispersions of the purely water-soluble drug fluconazole were successfully prepared by spray drying using hydrophilic carrier

International Journal of Drug Delivery

English

Solid Dispersions of Poorly Water Soluble Drug Using Spray Drying Technique

http://www.arjournals.org/index.php/ijdd/article/download/1007/pdf

Postdoctoral Fellowship 2014-2015/Carnegie Mellon University

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International Journal of Drug Delivery