272 research outputs found
Lipids, curvature, and nano-medicine*
The physical properties of the lamellar lipid-bilayer component of biological membranes are controlled by a host of thermodynamic forces leading to overall tensionless bilayers with a conspicuous lateral pressure profile and build-in curvature-stress instabilities that may be released locally or globally in terms of morphological changes. In particular, the average molecular shape and the propensity of the different lipid and protein species for forming non-lamellar and curved structures are a source of structural transitions and control of biological function. The effects of different lipids, sterols, and proteins on membrane structure are discussed and it is shown how one can take advantage of the curvature-stress modulations brought about by specific molecular agents, such as fatty acids, lysolipids, and other amphiphilic solutes, to construct intelligent drug-delivery systems that function by enzymatic triggering via curvature
The dynamics of the surface layer of lipid membranes doped by vanadium complex: computer modeling and EPR studies
Penetration of the liposome membranes doped with vanadium complex formed in the liquid-crystalline
phase from egg yolk lecithin (EYL) by the TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) spin probes has been
investigated. The penetration process was followed by 360 hours at 24◦C, using the electron spin resonance
(EPR) method. The spectroscopic parameter of the partition (F) of this probe indicated that a maximum rigidity
of the membrane was at 3% concentration of the vanadium complex. Computer simulations showed that the
increase in the rigidity of the membrane corresponds to the closure of gaps in the surface layer of the membrane,
and indicates the essential role of the membrane surface in transport processes
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