Amelogenin Stimulates Bone Sialoprotein (BSP) Expression Through Fibroblast Growth Factor 2 Response Element and Transforming Growth Factorâ β1 Activation Element in the Promoter of the BSP Gene

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141420/1/jper1482.pd

Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies

Ethanol extracts (AF-06, 07, and 08, 10 mg/kg) of Brazilian propolis were administered orally to cutaneously herpes simplex virus type 1 (HSV-1)-infected mice three times daily on days 0 to 6 after infection to evaluate their efficacies against HSV-1 infection and significantly limited development of herpetic skin lesions. AF-07 and 08 significantly reduced virus titers in brain and/or skin on day 4 without toxicity, but AF-08 had no anti-HSV-1 activity in vitro. AF-06 and 08 significantly enhanced delayed-type hypersensitivity (DTH) to inactivated HSV-1 antigen in infected mice. Oral AF-08-administration significantly augmented interferon (IFN)-γ production by HSV-1 antigen from splenocytes of HSV-1-infected mice, while direct exposure of splenocytes of infected mice to AF-06 significantly elevated IFN-γ production in vitro. Thus, AF-08 might have components that are active in vivo even after oral administration and those of AF-06 might be active only in vitro. Because DTH is a major host defense for intradermal HSV-1 infection, augmentation of DTH response by AF-06 or 08, directly or indirectly, respectively, may contribute to their efficacies against HSV-1 infection. In addition, AF-06 and 07 possibly contain anti-HSV-1 components contributing to their efficacies. Such biological activities of Brazilian propolis may be useful to analyze its pharmacological actions

A Comparative Study of the Uses of English Relative Pronouns Found in Some Japanese and Malaysian Secondary School English Textbooks

The purpose of this project report is to make a small corpus of relative clauses found in some Japanese junior/senior high EFL textbooks and Malaysian senior high ESL textbooks, and to examine the distribution and features of the use of relative clauses in them. English relative clauses follow the head noun, which is true in most European languages; in contrast, Japanese, Chinese, and Korean all require that the relative clauses occur before the head noun, so native speakers of these Asian languages will have some difficulty in grasping this fundamental syntactic difference in learning English. Considering that a textbook is the single most important resource of input for learners, it will be of vital importance to know what kinds of usage samples are available for learners through textbooks. In this study, sentences using relative clauses were collected from the analyzed textbooks and over 1,000 samples were collected and categorized based on the categories provided by Ellis (1994). As a result, this study identified similarity in terms of the frequency and features of relative clauses used in both countries’ English textbooks and also gave evidence of influence on Japanese students’ writings in English

Status Report of Neutral Kaon photo-production study using Neutral Kaon Spectrometer 2 (NKS2) at LNS-Tohoku(I. Nuclear Physics)

The approach described in this paper uses an array of Field Programmable Gate Array (FPGA) devices to implement a fault tolerant hardware system that can be compared to the running of fault tolerant software on a traditional processor. Fault tolerance is achieved is achieved by using FPGA with on the fly partial programmability feature. Major considerations while mapping to the FPGA includes the size of the area to be mapped and communication issues related to their communication. Area size selection is compared to the page size selection in Operating System Design. Communication issues between modules are compared to the software engineering paradigms dealing with module coupling, fan-in, fan-out and cohesiveness. Finally, the overhead associated with the downloading of the reconfiguration files is discussed

Twisting strategy applied to N,N-diorganoquinacridones leads to organic chromophores exhibiting efficient solid-state fluorescence

A new molecular design of organic emitters exhibiting efficient solid-state fluorescence, which involves planarity breaking of N, N-diorganoquinacridones, is presented. The new design principle led to the development of dimethyl 2, 5-diaminoterephthalates and 2, 5-diamino-1, 4-diaroylbenzenes, which emitted green to yellow and yellow to red light with high-to-excellent quantum yields, respectively. In addition, the photoluminescence properties of the diaroylbenzenes were dependent on the morphology and reversibly variable by thermal and solvent vapor stimuli