‘Drop, Cover and Hold On’ or ‘Triangle of Life’ Attributes of Information Sources Influencing Earthquake Protective Actions

A well-known fact is that an earthquake or earth shaking does not cause injuries and deaths. Rather, buildings and infrastructure systems collapsing on people do. Hence, reputable government organizations from countries prone to high earthquake risks are heavily invested in advising their populations on immediate lifesaving protective actions (PAs). One such action is the ‘Drop, Cover and Hold on’ strategy proven to have saved countless lives. Unfortunately, in recent years another action known as the ‘Triangle of Life’ has been trolled through internet sites and hearsay. It is believed that adopting such an unsubstantiated erroneous action is likely to put people at greater risk during an earthquake. Thus, there is a need to extend studies to understand factors that influence people’s decisions to take certain PAs over another for earthquakes. This research does that through an empirical study of 647 residents from Mianyang City in the Sichuan province of China. The results indicate that if a PA is easy to understand, mentioned often by multiple sources and easy to access, then people will adopt it. But a striking finding is that people are also likely to be influenced by wrong information, depending on who is providing such information and through which medium (e.g. social media). These findings suggest that the Chinese government needs to provide gate keepers who are dedicated, trained personnel who can monitor misinformation on various Internet sites and address them. In parallel they can provide regular, up to date public advisories on immediate PA through multiple legitimate government, private and non-profit sector sources and channels

Local Residents’ Risk Perceptions in Response to Shale Gas Exploitation: Evidence from China

In 2014, China became the world’s third country to accomplish shale gas commercial development, following the United States and Canada. China still however lacks a comprehensive analysis of its public’s concerns about potential environmental risks of shale gas exploration, particularly those of local residents near extraction sites. This paper specifically aims to explore risks perceived as associated with shale gas development in the Changning-Weiyuan area of Sichuan Basin, by conducting a face-to-face household survey with 730 participants interviewed. Some 86% of respondents reported their belief that shale gas exploitation causes more than three types of negative impacts, the most commonly perceived being noise, underground water contamination and geological disruption. Associated variables that were statistically significant predictors of risk perception include demographic characteristics (age, gender, education), environmental awareness level, landslide experience, awareness of past shale gas accidents, information sources, general knowledge about shale gas, and perspectives on whether negative impacts can be observed and controlled, along with trust in the central government and the petroleum company. Our findings implications are discussed, with the goal of informing both central and local authorities’ policy development in protecting local residents from risks of shale gas exploitation and better communicating risks to residents

KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites

KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are learned from the kinase-specific groups of the phosphorylation sites. After evaluating the learned models, the model with highest accuracy was selected from each kinase-specific group, for use in a web-based prediction tool for identifying protein phosphorylation sites. Therefore, this work developed a kinase-specific phosphorylation site prediction tool with both high sensitivity and specificity. The prediction tool is freely available at

Quasi-Hermitian extended SSH models

We consider the quasi Hermitian limit of a non-Hermitian extended Su Schrieffer Heeger model, in which the hopping amplitudes obey a specific relation so that the system may be mapped to a corresponding Hermitian one and its energy spectrum is completely real. Analogous to the Hermitian case, one may use the modified winding number to determine the total number of edge states on the boundaries to achieve a modified bulk-boundary correspondence. Due to the skin effect in nonHermitian systems, the spectral winding numbers must be used to classify such systems further. It dictates how the edge states would be distributed over the left and right boundaries. We then naively extend the criteria to the cases that the quasi Hermitian condition is violated. For all the cases that we consider, no inconsistency has been found.Comment: 21 pages, 10 figure

Temporal Arteritis

Temporal arteritis, a chronic inflammatory vasculitis involving medium- and large-sized arteries, has rarely been reported in Asia. However, we report 2 cases, in which the patients initially presented with headache. Physical examination disclosed engorged, hard and palpable vessels in the temporal areas. Temporal-artery biopsy revealed 2 different types of arteritis: the multinucleated giant cell type and the panarteritis type without multinucleated giant cells. One patient was positive for immunoglobulin G anticardiolipin antibody. The pathologic findings of the different subsets of temporal arteritis, and the relationship between anticardiolipin antibody and the extent of vascular complications of temporal arteritis, are discussed

CMOS Image Sensor with a Built-in Lane Detector

This work develops a new current-mode mixed signal Complementary Metal-Oxide-Semiconductor (CMOS) imager, which can capture images and simultaneously produce vehicle lane maps. The adopted lane detection algorithm, which was modified to be compatible with hardware requirements, can achieve a high recognition rate of up to approximately 96% under various weather conditions. Instead of a Personal Computer (PC) based system or embedded platform system equipped with expensive high performance chip of Reduced Instruction Set Computer (RISC) or Digital Signal Processor (DSP), the proposed imager, without extra Analog to Digital Converter (ADC) circuits to transform signals, is a compact, lower cost key-component chip. It is also an innovative component device that can be integrated into intelligent automotive lane departure systems. The chip size is 2,191.4 × 2,389.8 μm, and the package uses 40 pin Dual-In-Package (DIP). The pixel cell size is 18.45 × 21.8 μm and the core size of photodiode is 12.45 × 9.6 μm; the resulting fill factor is 29.7%

Rhodiola crenulata extract for prevention of acute mountain sickness: a randomized, double-blind, placebo-controlled, crossover trial

BACKGROUND: Rhodiola crenulata (R. crenulata) is widely used to prevent acute mountain sickness in the Himalayan areas and in Tibet, but no scientific studies have previously examined its effectiveness. We conducted a randomized, double-blind, placebo-controlled crossover study to investigate its efficacy in acute mountain sickness prevention. METHODS: Healthy adult volunteers were randomized to 2 treatment sequences, receiving either 800 mg R. crenulata extract or placebo daily for 7 days before ascent and 2 days during mountaineering, before crossing over to the alternate treatment after a 3-month wash-out period. Participants ascended rapidly from 250 m to 3421 m on two separate occasions: December 2010 and April 2011. The primary outcome measure was the incidence of acute mountain sickness, as defined by a Lake Louise score ≥ 3, with headache and at least one of the symptoms of nausea or vomiting, fatigue, dizziness, or difficulty sleeping. RESULTS: One hundred and two participants completed the trial. There were no demographic differences between individuals taking Rhodiola-placebo and those taking placebo-Rhodiola. No significant differences in the incidence of acute mountain sickness were found between R. crenulata extract and placebo groups (all 60.8%; adjusted odds ratio (AOR) = 1.02, 95% confidence interval (CI) = 0.69–1.52). The incidence of severe acute mountain sickness in Rhodiola extract vs. placebo groups was 35.3% vs. 29.4% (AOR = 1.42, 95% CI = 0.90–2.25). CONCLUSIONS: R. crenulata extract was not effective in reducing the incidence or severity of acute mountain sickness as compared to placebo. TRIAL REGISTRATION: ClinicalTrials.gov NCT01536288

Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis

X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a degenerative retinopathy with a retinal splitting phenotype. We generated human induced pluripotent stem cells (hiPSCs) from patients to study XLRS in a 3D retinal organoid in vitro differentiation system. This model recapitulates key features of XLRS including retinal splitting, defective retinoschisin production, outer-segment defects, abnormal paxillin turnover, and impaired ER-Golgi transportation. RS1 mutation also affects the development of photoreceptor sensory cilia and results in altered expression of other retinopathy-associated genes. CRISPR/Cas9 correction of the disease-associated C625T mutation normalizes the splitting phenotype, outer-segment defects, paxillin dynamics, ciliary marker expression, and transcriptome profiles. Likewise, mutating RS1 in control hiPSCs produces the disease-associated phenotypes. Finally, we show that the C625T mutation can be repaired precisely and efficiently using a base-editing approach. Taken together, our data establish 3D organoids as a valid disease model