New free-air and Bouguer gravity fields of Taiwan from multiple platforms and sensors

We construct 1' × 1' grids of free-air and Bouguer gravity anomalies around Taiwan with well-defined error estimates for quality assessment. The grids are compiled from land, airborne and shipborne gravity measurements, augmented with altimeter gravity at sea. Three sets of relative land gravity measurements are network-adjusted and outlier-edited, yielding accuracies of 0.03–0.09 mGal. Three airborne gravity sets are collected at altitudes 5156 and 1620 m with accuracies of 2.57–2.79 mGal. Seven offshore shipborne gravity campaigns around Taiwan and its offshore islands yield shallow-water gravity values with 0.88–2.35 mGal accuracies. All data points are registered with GPS-derived geodetic coordinates at cm–dm accuracies, allowing for precise gravity reductions and computing gravity disturbances. The various datasets are combined by the band-limited least-squares collocation in a one-step procedure. In the eastern mountainous (or offshore) region, Bouguer anomalies and density contrasts without considering the oceanic (or land) topographic contribution are underestimated. The new grids show unprecedented tectonic features that can revise earlier results, and can be used in a broad range of applications

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab-on-a-chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic-based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab-on-a-chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques

Identification and phylogenetic analysis of orf virus from goats in Taiwan

An outbreak of contagious ecthyma in goats in central Taiwan was investigated. The disease was diagnosed by physical and histopathologic examinations, and the etiology of the disease was identified as orf virus by electron microscopy and polymerase chain reaction (PCR) and sequence of major envelope protein (B2L) gene. The entire protein-coding region of B2L gene were cloned and sequenced. Phylogenetic analysis of B2L amino acid sequences showed that the orf virus identified in this outbreak was closer to the Indian ORFV-Mukteswar 59/05 isolate. This is the first report on the molecular characterization of orf virus in Taiwan

A Note on Domain Walls and the Parameter Space of N=1 Gauge Theories

We study the spectrum of BPS domain walls within the parameter space of N=1 U(N) gauge theories with adjoint matter and a cubic superpotential. Using a low energy description obtained by compactifying the theory on R^3 x S^1, we examine the wall spectrum by combining direct calculations at special points in the parameter space with insight drawn from the leading order potential between minimal walls, i.e those interpolating between adjacent vacua. We show that the multiplicity of composite BPS walls -- as characterised by the CFIV index -- exhibits discontinuities on marginal stability curves within the parameter space of the maximally confining branch. The structure of these marginal stability curves for large N appears tied to certain singularities within the matrix model description of the confining vacua.Comment: 33 pages, LaTeX, 6 eps figures; v2: references adde

Information science and cognitive psychology: a theoretical approach

Information, as a human and social phenomenon, is the object of study of an emergent scientific field named Information Science (IS), which we put forward as unitary and transdisciplinary and open to a rich interdisciplinarity with other fields of knowledge. In face of the new reality, baptized the Information Society', and the emergence of a new paradigm, that we name "post-custodial, scientific and informational", as opposed to the previous one, "historicist, custodial and technicist", it is urgent to consolidate the theoretical and methodological foundations of IS in order to develop research, both pure and applied, and to contribute to a definition of its boundaries as a scientific area, in the scope of Social Sciences. Starting from an operative definition of Information, this paper aims to discuss the cognitive and emotional dimension of the info-communicational phenomenon and, for that, it is crucial to start a profound and hard dialogue with Cognitive Sciences. The label of 'cognitivist' given, in IS literature, to some authors like Bertram Brookes, because of the emphasis he put on the passage from a state of knowledge to a new state through an addition of knowledge coming from an increase of information, sounds quite equivocal, because knowledge and cognition are not synonymous and cognitive and emotional activity is not reducible to formalities. It is necessary to compare concepts and to understand the neuropsychological roots of the production, the organization and the info-communicational behaviour, so the contribution of Neurosciences and Cognitive Sciences, namely Cognitive Psychology, is indispensable

Multiscale electrochemical analysis of the corrosion of titanium and nitinol for implant applications

Surface electrochemical activity of titanium and nitinol biomaterials in naturally aerated Ringer’s physiological solution was investigated using potentiodynamic polarization and scanning electrochemical microscopy (SECM) techniques. SECM was operated in feedback and redox competition modes as a function of potential applied to the substrate. The kinetics of the electron transfer rate on both materials was characterized by mathematical modelling of the Z-approach curves monitored under feedback conditions. The rate constant values greatly depended on the characteristics of the passive layers formed over the metals under potentiostatic control. A more insulating film was found on nitinol when biased at low polarizations, resulting in smaller tip current increments during tip approach to the investigated surface under positive feedback and competition operation modes. However, at higher anodic polarizations, nitinol passive layers experience breakdown, and therefore tip current values reflect the release of metal cations from the biomaterial surfac

Integrative molecular characterization of malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1 alterations to date. We identified histology-independent molecular prognostic subsets, and defined a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity. We also report strong expression of the immune-checkpoint gene VISTA in epithelioid MPM, strikingly higher than in other solid cancers, with implications for the immune response to MPM and for its immunotherapy. Our findings highlight new avenues for further investigation of MPM biology and novel therapeutic options. SIGNIFICANCE: Through a comprehensive integrated genomic study of 74 MPMs, we provide a deeper understanding of histology-independent determinants of aggressive behavior, define a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity, and discovered strong expresssion of the immune-checkpoint gene VISTA in epithelioid MPM

Lack of abnormal pain sensitivity in the P2X7 Knockout Mice after Thalamic Hemorrhagic Lesion.

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Lack of Allodynia and Thalamic Hyper-excitatory in the P2X7 Knockout Mice after Thalamic Hemorrhage Lesion.

[[sponsorship]]生物醫學科學研究所[[note]]已出版;有審查制度;具代表