Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation.

Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the activation of the small GTP binding protein TC10. We now demonstrate that TC10 is processed through the secretory membrane trafficking system and localizes to caveolin-enriched lipid raft microdomains. Although insulin activated the wild-type TC10 protein and a TC10/H-Ras chimera that were targeted to lipid raft microdomains, it was unable to activate a TC10/K-Ras chimera that was directed to the nonlipid raft domains. Similarly, only the lipid raft-localized TC10/ H-Ras chimera inhibited GLUT4 translocation, whereas the TC10/K-Ras chimera showed no significant inhibitory activity. Furthermore, disruption of lipid raft microdomains by expression of a dominant-interfering caveolin 3 mutant (Cav3/DGV) inhibited the insulin stimulation of GLUT4 translocation and TC10 lipid raft localization and activation without affecting PI-3 kinase signaling. These data demonstrate that the insulin stimulation of GLUT4 translocation in adipocytes requires the spatial separation and distinct compartmentalization of the PI-3 kinase and TC10 signaling pathways

Probabilistic Prediction of Chaotic Time Series Using Similarity of Attractors and LOOCV Predictable Horizons for Obtaining Plausible Predictions

This paper presents a method for probabilistic prediction of chaotic time series. So far, we have developed several model selection methods for chaotic time series prediction, but the methods cannot estimate the predictable horizon of predicted time series. Instead of using model selection methods employing the estimation of mean square prediction error (MSE), we present a method to obtain a probabilistic prediction which provides a prediction of time series and the estimation of predictable horizon. The method obtains a set of plausible predictions by means of using the similarity of attractors of training time series and the time series predicted by a number of learning machines with different parameter values, and then obtains a smaller set of more plausible predictions with longer predictable horizons estimated by LOOCV (leave-one-out cross-validation) method. The effectiveness and the properties of the present method are shown by means of analyzing the result of numerical experiments.22nd International Conference, ICONIP 2015, November 9-12, 2015, Istanbul, Turke

Организационные резервы повышения производительности труда на предприятиях нефтегазовой отрасли

Проблема повышения производительности труда в современной экономике России имеет значительную актуальность, поскольку повышение уровня производительности труда является важнейшим условием социально-экономического развития общества, устойчивого экономического роста и повышения конкурентоспособности национальной экономики. Актуальность представленного исследования определяется необходимостью повышения производительности труда на современных предприятиях России, что может быть достигнуто за счет реализации организационных резервов роста. Целью исследования является структурирование факторов, оказывающих влияние на уровень производительности труда, подтверждение значимости организационных резервов роста, апробация методики выявления организационных резервов повышения производительности труда. Методы исследования. В настоящей работе нашли применение методы сбора первичной экономической информации, включая анализ законодательных и нормативно-правовых актов РФ, официальных статистических данных, данных публичной отчетности отечественных предприятий, анализ прочих открытых источников информации, системный подход, методы статистического и сравнительного анализа. The country's labor productivity in modern Russia over recent years has acquired impressive relevance. Since it is a key indicator of overall economic efficiency, strong labor productivity growth has always been a sufficient condition for socio-economic development, economic stability and enhancing competitiveness of the national economy. The relevance of the study is determined by the urgency of the labor productivity growth at the modern Russian factories that can be achieved through realization of organizational reserves. The main aim of the study is identifying and structuring the factors that seem to affect labor productivity level. It is also pointed at corroborating the necessity of labor productivity growth and approbation of organizational reserves seeking method. Methods. In the present work different methods of information gathering and processing were used to obtain the economic data including the analysis of appropriate laws and regulations, official statistics, companies' public statements and reporting and other open available resources. Also system approach, comparative and statistical analysis were adopted in this research

Efficient room-temperature magnetization direction detection by means of the enhanced anomalous Nernst effect in a Weyl ferromagnet

Spintronic phenomena exhibiting a longitudinal resistance change under magnetization reversal are a quite novel feature in nanoscience, which has been intensively studied in hopes of realizing all-electrical magnetization direction detection devices, where no reference ferromagnetic layer is required. However, cryogenic temperatures and/or high magnetic fields have been required to achieve noticeable effects. Here, the high heat-to-charge conversion efficiency of the Heusler alloy Weyl semimetal Co₂MnGa is exploited in single layer nanoscaled wires at room temperature to produce at least two orders of magnitude enhancement of the resistance change ratio, when compared with conventional ferromagnets. Such resistance change under magnetization reversal is consistently explained through temperature distribution simulations and direct thermoelectric measurements of the large anomalous Nernst effect (ANE) in this topologically nontrivial material. Although many reports consider ANE signals as perturbations or undesired artifacts, we demonstrate that they are dominant in this system and can be seized for nonvolatile memory readout, as shown in a prototype device. These results open up new horizons of using enhanced thermoelectric voltages in novel materials for magnetization direction detection in any system where significant temperature gradients exist

Landau Model for Commensurate-Commensurate Phase Transitions in Uniaxial Improper Ferroelectric Crystals

We propose the Landau model for lock-in phase transitions in uniaxially modulated improper ferroelectric incommensurate-commensurate systems of class I. It includes Umklapp terms of third and fourth order and secondary order parameter representing the local polarization. The corresponding phase diagram has the structure of harmless staircase, with the allowed wave numbers obeying the Farey tree algorithm. Among the stable commensurate phases only those with periods equal to odd number of lattice constants have finite macroscopic polarizations. These results are in excellent agreement with experimental findings in some A2BX4 compounds.Comment: 9 pages, 5 figures, revtex, to be published in Journal of Physics: Cond. Matter as a Letter to the Edito

In vitro transcription of compound heterozygous hypofibrinogenemia Matsumoto IX; first identification of FGB IVS6 deletion of 4 nucleotides and FGG IVS3-2A > G causing abnormal RNA splicing

ArticleClinica Chimica Acta. 411(17-18):1325-1329 (2010)journal articl

Investigation of the thermal tolerance of silicon-based lateral spin valves

Improvement in the thermal tolerance of Si-based spin devices is realized by employing thermally stable nonmagnetic (NM) electrodes. For Au/Ta/Al electrodes, intermixing between Al atoms and Au atoms occurs at approximately 300 °C, resulting in the formation of a Au/Si interface. The Au–Si liquid phase is formed and diffuses mainly along an in-plane direction between the Si and AlN capping layers, eventually breaking the MgO layer of the ferromagnetic (FM) metal/MgO electrodes, which is located 7 µm away from the NM electrodes. By changing the layer structure of the NM electrode from Au/Ta/Al to Au/Ta, the thermal tolerance is clearly enhanced. Clear spin transport signals are obtained even after annealing at 400 °C. To investigate the effects of Mg insertion in FM electrodes on thermal tolerance, we also compare the thermal tolerance among Fe/Co/MgO, Fe/Co/Mg/MgO and Fe/Co/MgO/Mg contacts. Although a highly efficient spin injection has been reported by insertion of a thin Mg layer below or above the MgO layer, these thermal tolerances decrease obviously