Hybrid biomedical intelligent systems

"Copyright © 2012 Maysam Abbod et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."The purpose of this special issue is to promote research and developments of the best work in the field of hybrid intelligent systems for biomedical applications

Type-2 fuzzy sets applied to multivariable self-organizing fuzzy logic controllers for regulating anesthesia

In this paper, novel interval and general type-2 self-organizing fuzzy logic controllers (SOFLCs) are proposed for the automatic control of anesthesia during surgical procedures. The type-2 SOFLC is a hierarchical adaptive fuzzy controller able to generate and modify its rule-base in response to the controller's performance. The type-2 SOFLC uses type-2 fuzzy sets derived from real surgical data capturing patient variability in monitored physiological parameters during anesthetic sedation, which are used to define the footprint of uncertainty (FOU) of the type-2 fuzzy sets. Experimental simulations were carried out to evaluate the performance of the type-2 SOFLCs in their ability to control anesthetic delivery rates for maintaining desired physiological set points for anesthesia (muscle relaxation and blood pressure) under signal and patient noise. Results show that the type-2 SOFLCs can perform well and outperform previous type-1 SOFLC and comparative approaches for anesthesia control producing lower performance errors while using better defined rules in regulating anesthesia set points while handling the control uncertainties. The results are further supported by statistical analysis which also show that zSlices general type-2 SOFLCs are able to outperform interval type-2 SOFLC in terms of their steady state performance

Superconductivity from D3/D7: Holographic Pion Superfluid

We show that a D3/D7 system (at zero quark mass limit) at finite isospin chemical potential goes through a superconductor (superfluid) like phase transition. This is similar to a flavored superfluid phase studied in QCD literature, where mesonic operators condensate. We have studied the frequency dependent conductivity of the condensate and found a delta function pole in the zero frequency limit. This is an example of superconductivity in a string theory context. Consequently we have found a superfluid/supercurrent type solution and studied the associated phase diagram. The superconducting transition changes from second order to first order at a critical superfluid velocity. We have studied various properties of the superconducting system like superfluid density, energy gap, second sound etc. We investigate the possibility of the isospin chemical potential modifying the embedding of the flavor branes by checking whether the transverse scalars also condense at low temperature. This however does not seem to be the case.Comment: 18 pages, 8 figures, revtex

Landau Levels, Magnetic Fields and Holographic Fermi Liquids

We further consider a probe fermion in a dyonic black hole background in anti-de Sitter spacetime, at zero temperature, comparing and contrasting two distinct classes of solution that have previously appeared in the literature. Each class has members labeled by an integer n, corresponding to the n-th Landau level for the fermion. Our interest is the study of the spectral function of the fermion, interpreting poles in it as indicative of quasiparticles associated with the edge of a Fermi surface in the holographically dual strongly coupled theory in a background magnetic field H at finite chemical potential. Using both analytical and numerical methods, we explicitly show how one class of solutions naturally leads to an infinite family of quasiparticle peaks, signaling the presence of a Fermi surface for each level n. We present some of the properties of these peaks, which fall into a well behaved pattern at large n, extracting the scaling of Fermi energy with n and H, as well as the dispersion of the quasiparticles.Comment: 23 pages, 4 figures. Changed some of the terminology: non-separable -> infinite-sum. Clarified the relationship between our ansatz and the separable ansat

THE STRUCTURE OF A HYDRATED 1-2 COMPLEX OF "ADENYLYL(3'-5')ADENOSINE-PROFLAVINE HEMISULFATE

The 1:2 complex (M r = 1410.28) between adenylyl(3'- 5')adenosine (ApA), C20H25NIoOIoP, and proflavine hemisulphate, 2C 13H ~2N~ - . SO42-, crystallizes with 16.5 water molecules in the space group P21212 and unit-cell parameters a = 32.157 (5), b = 21.450 (4) and c = 10.175 (1) A; V = 7018.4 A 3, Z = 4, d c = 1.33, d m = 1.32 Mgm -3,/z(Cu Ka) = 1.32 mm -~, F(000) = 2980. Crystal data were measured up to 20 = 120 ° with Cu Ka radiation. The structure was determined by a multisolution phase method and refined by a blockedmode full-matrix least-squares procedure. The final R factor is 0.118 for 3507 observed data. The dinucleoside phosphate, ApA, in this structure has a very unusual conformation which is not found in other oligonucleotide structures. The backbone of ApA is extended and each adenine ring is hydrogen bonded to another symmetry-related one forming an adenineadenine base pair. Each base pair is sandwiched by proflavine cations which also stack with each other. Solvent molecules lie in the continuous channels between columns of stacked heterocyclic rings

Thermoelastic Damping in Micro- and Nano-Mechanical Systems

The importance of thermoelastic damping as a fundamental dissipation mechanism for small-scale mechanical resonators is evaluated in light of recent efforts to design high-Q micrometer- and nanometer-scale electro-mechanical systems (MEMS and NEMS). The equations of linear thermoelasticity are used to give a simple derivation for thermoelastic damping of small flexural vibrations in thin beams. It is shown that Zener's well-known approximation by a Lorentzian with a single thermal relaxation time slightly deviates from the exact expression.Comment: 10 pages. Submitted to Phys. Rev.

Quantum geometry and gravitational entropy

Most quantum states have wavefunctions that are widely spread over the accessible Hilbert space and hence do not have a good description in terms of a single classical geometry. In order to understand when geometric descriptions are possible, we exploit the AdS/CFT correspondence in the half-BPS sector of asymptotically AdS_5 x S^5 universes. In this sector we devise a "coarse-grained metric operator" whose eigenstates are well described by a single spacetime topology and geometry. We show that such half-BPS universes have a non-vanishing entropy if and only if the metric is singular, and that the entropy arises from coarse-graining the geometry. Finally, we use our entropy formula to find the most entropic spacetimes with fixed asymptotic moments beyond the global charges.Comment: 29 pages, 2 figures; references adde