2,146 research outputs found
Two-dimensional matrix algorithm using detrended fluctuation analysis to distinguish Burkitt and diffuse large B-cell lymphoma
Copyright © 2012 Rong-Guan Yeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.A detrended fluctuation analysis (DFA) method is applied to image analysis. The 2-dimensional (2D) DFA algorithms is proposed
for recharacterizing images of lymph sections. Due to Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL), there
is a significant different 5-year survival rates after multiagent chemotherapy. Therefore, distinguishing the difference between BL
and DLBCL is very important. In this study, eighteen BL images were classified as group A, which have one to five cytogenetic
changes. Ten BL images were classified as group B, which have more than five cytogenetic changes. Both groups A and B BLs are
aggressive lymphomas, which grow very fast and require more intensive chemotherapy. Finally, ten DLBCL images were classified
as group C. The short-term correlation exponent α1 values of DFA of groups A, B, and C were 0.370 ± 0.033, 0.382 ± 0.022, and
0.435 ± 0.053, respectively. It was found that α1 value of BL image was significantly lower (P < 0.05) than DLBCL. However, there
is no difference between the groups A and B BLs. Hence, it can be concluded that α1 value based on DFA statistics concept can
clearly distinguish BL and DLBCL image.National Science Council (NSC) of Taiwan the Center for Dynamical Biomarkers and
Translational Medicine, National Central University, Taiwan (also sponsored by National Science Council)
Magnetic Behavior of a Mixed Ising Ferrimagnetic Model in an Oscillating Magnetic Field
The magnetic behavior of a mixed Ising ferrimagnetic system on a square
lattice, in which the two interpenetrating square sublattices have spins +- 1/2
and spins +-1,0, in the presence of an oscillating magnetic field has been
studied with Monte Carlo techniques. The model includes nearest and
next-nearest neighbor interactions, a crystal field and the oscillating
external field. By studying the hysteretic response of this model to an
oscillating field we found that it qualitatively reproduces the increasing of
the coercive field at the compensation temperature observed in real
ferrimagnets, a crucial feature for magneto-optical applications. This behavior
is basically independent of the frequency of the field and the size of the
system. The magnetic response of the system is related to a dynamical
transition from a paramagnetic to a ferromagnetic phase and to the different
temperature dependence of the relaxation times of both sublattices.Comment: 10 figures. To be published in Phys.Rev
THE STRUCTURE OF A HYDRATED 1-2 COMPLEX OF "ADENYLYL(3'-5')ADENOSINE-PROFLAVINE HEMISULFATE
The 1:2 complex (M r = 1410.28) between adenylyl(3'-
5')adenosine (ApA), C20H25NIoOIoP, and proflavine
hemisulphate, 2C 13H ~2N~ - . SO42-, crystallizes with 16.5
water molecules in the space group P21212 and unit-cell
parameters a = 32.157 (5), b = 21.450 (4) and c =
10.175 (1) A; V = 7018.4 A 3, Z = 4, d c = 1.33, d m =
1.32 Mgm -3,/z(Cu Ka) = 1.32 mm -~, F(000) = 2980.
Crystal data were measured up to 20 = 120 ° with Cu
Ka radiation. The structure was determined by a
multisolution phase method and refined by a blockedmode
full-matrix least-squares procedure. The final R
factor is 0.118 for 3507 observed data. The dinucleoside
phosphate, ApA, in this structure has a very
unusual conformation which is not found in other
oligonucleotide structures. The backbone of ApA is
extended and each adenine ring is hydrogen bonded to
another symmetry-related one forming an adenineadenine
base pair. Each base pair is sandwiched by
proflavine cations which also stack with each other.
Solvent molecules lie in the continuous channels
between columns of stacked heterocyclic rings
Coarse-Graining the Lin-Maldacena Geometries
The Lin-Maldacena geometries are nonsingular gravity duals to degenerate
vacuum states of a family of field theories with SU(2|4) supersymmetry. In this
note, we show that at large N, where the number of vacuum states is large,
there is a natural `macroscopic' description of typical states, giving rise to
a set of coarse-grained geometries. For a given coarse-grained state, we can
associate an entropy related to the number of underlying microstates. We find a
simple formula for this entropy in terms of the data that specify the geometry.
We see that this entropy function is zero for the original microstate
geometries and maximized for a certain ``typical state'' geometry, which we
argue is the gravity dual to the zero-temperature limit of the thermal state of
the corresponding field theory. Finally, we note that the coarse-grained
geometries are singular if and only if the entropy function is non-zero.Comment: 29 pages, LaTeX, 3 figures; v2 references adde
Hip fracture risk assessment: Artificial neural network outperforms conditional logistic regression in an age- and sex-matched case control study
Copyright @ 2013 Tseng et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.Background - Osteoporotic hip fractures with a significant morbidity and excess mortality among the elderly have imposed huge health and economic burdens on societies worldwide. In this age- and sex-matched case control study, we examined the risk factors of hip fractures and assessed the fracture risk by conditional logistic regression (CLR) and ensemble artificial neural network (ANN). The performances of these two classifiers were compared.
Methods - The study population consisted of 217 pairs (149 women and 68 men) of fractures and controls with an age older than 60 years. All the participants were interviewed with the same standardized questionnaire including questions on 66 risk factors in 12 categories. Univariate CLR analysis was initially conducted to examine the unadjusted odds ratio of all potential risk factors. The significant risk factors were then tested by multivariate analyses. For fracture risk assessment, the participants were randomly divided into modeling and testing datasets for 10-fold cross validation analyses. The predicting models built by CLR and ANN in modeling datasets were applied to testing datasets for generalization study. The performances, including discrimination and calibration, were compared with non-parametric Wilcoxon tests.
Results - In univariate CLR analyses, 16 variables achieved significant level, and six of them remained significant in multivariate analyses, including low T score, low BMI, low MMSE score, milk intake, walking difficulty, and significant fall at home. For discrimination, ANN outperformed CLR in both 16- and 6-variable analyses in modeling and testing datasets (p?<?0.005). For calibration, ANN outperformed CLR only in 16-variable analyses in modeling and testing datasets (p?=?0.013 and 0.047, respectively).
Conclusions - The risk factors of hip fracture are more personal than environmental. With adequate model construction, ANN may outperform CLR in both discrimination and calibration. ANN seems to have not been developed to its full potential and efforts should be made to improve its performance.National Health Research Institutes in Taiwa
Coherent Pair Production by Photons in the 20-170 GeV Energy Range Incident on Crystals and Birefringence
The cross section for coherent pair production by linearly polarised photons
in the 20-170 GeV energy range was measured for photon aligned incidence on
ultra-high quality diamond and germanium crystals. The theoretical description
of coherent bremsstrahlung and coherent pair production phenomena is an area of
active theoretical debate and development. However, under our experimental
conditions, the theory predicted the combined cross section and polarisation
experimental observables very well indeed. In macroscopic terms, our experiment
measured a birefringence effect in pair production in a crystal. This study of
this effect also constituted a measurement of the energy dependent linear
polarisation of photons produced by coherent bremsstrahlung in aligned
crystals. New technologies for manipulating high energy photon beams can be
realised based on an improved understanding of QED phenomena at these energies.
In particular, this experiment demonstrates an efficient new polarimetry
technique. The pair production measurements were done using two independent
methods simultaneously. The more complex method using a magnet spectrometer
showed that the simpler method using a multiplicity detector was also viable.Comment: 10 pages, 13 figures, 1 table, REVTeX4 two column, Version for
publicatio
Quantum geometry and gravitational entropy
Most quantum states have wavefunctions that are widely spread over the
accessible Hilbert space and hence do not have a good description in terms of a
single classical geometry. In order to understand when geometric descriptions
are possible, we exploit the AdS/CFT correspondence in the half-BPS sector of
asymptotically AdS_5 x S^5 universes. In this sector we devise a
"coarse-grained metric operator" whose eigenstates are well described by a
single spacetime topology and geometry. We show that such half-BPS universes
have a non-vanishing entropy if and only if the metric is singular, and that
the entropy arises from coarse-graining the geometry. Finally, we use our
entropy formula to find the most entropic spacetimes with fixed asymptotic
moments beyond the global charges.Comment: 29 pages, 2 figures; references adde
Linear to Circular Polarisation Conversion using Birefringent Properties of Aligned Crystals for Multi-GeV Photons
We present the first experimental results on the use of a thick aligned Si
crystal acting as a quarter wave plate to induce a degree of circular
polarisation in a high energy linearly polarised photon beam. The linearly
polarised photon beam is produced from coherent bremsstrahlung radiation by 178
GeV unpolarised electrons incident on an aligned Si crystal, acting as a
radiator. The linear polarisation of the photon beam is characterised by
measuring the asymmetry in electron-positron pair production in a Ge crystal,
for different crystal orientations. The Ge crystal therefore acts as an
analyser. The birefringence phenomenon, which converts the linear polarisation
to circular polarisation, is observed by letting the linearly polarised photons
beam pass through a thick Si quarter wave plate crystal, and then measuring the
asymmetry in electron-positron pair production again for a selection of
relative angles between the crystallographic planes of the radiator, analyser
and quarter wave plate. The systematics of the difference between the measured
asymmetries with and without the quarter wave plate are predicted by theory to
reveal an evolution in the Stokes parameters from which the appearance of a
circularly polarised component in the photon beam can be demonstrated. The
measured magnitude of the circularly polarised component was consistent with
the theoretical predictions, and therefore is in indication of the existence of
the birefringence effect.Comment: 12 pages, 12 figures, 1 table, REVTeX4 two column, Version for
publicatio
The role of pathology in an investigation of an outbreak of West Nile encephalitis in New York, 1999.
An outbreak of encephalitis occurred in New York City in late August 1999, the first caused by West Nile virus in North America. Histopathologic and immunopathologic examinations performed on human autopsy materials helped guide subsequent laboratory and epidemiologic investigations that led to identification of the etiologic agent
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