538 research outputs found
Acoustically evoked potentials in two cephalopods inferred using the auditory brainstem response (ABR) approach
It is still a matter of debate whether cephalopods can detect sound frequencies above 400 Hz. So far there is no proof for the detection of underwater sound above 400 Hz via a physiological approach. The controversy of whether cephalopods have a sound detection ability above 400 Hz was tested using the auditory brainstem response (ABR) approach, which has been successfully applied in fish, crustaceans, amphibians, reptiles and birds. Using ABR we found that auditory evoked potentials can be obtained in the frequency range 400 to 1500 Hz (Sepiotheutis lessoniana) and 400 to 1000 Hz (Octopus vulgaris), respectively. The thresholds of S. lessoniana were generally lower than those of O. vulgaris
First Acetic Acid Survey with CARMA in Hot Molecular Cores
Acetic acid (CHCOOH) has been detected mainly in hot molecular cores
where the distribution between oxygen (O) and nitrogen (N) containing molecular
species is co-spatial within the telescope beam. Previous work has presumed
that similar cores with co-spatial O and N species may be an indicator for
detecting acetic acid. However, does this presumption hold as higher spatial
resolution observations become available of large O and N-containing molecules?
As the number of detected acetic acid sources is still low, more observations
are needed to support this postulate. In this paper, we report the first acetic
acid survey conducted with the Combined Array for Research in Millimeter-wave
Astronomy (CARMA) at 3 mm wavelengths towards G19.61-0.23, G29.96-0.02 and IRAS
16293-2422. We have successfully detected CHCOOH via two transitions toward
G19.61-0.23 and tentatively confirmed the detection toward IRAS 16293-2422 A.
The determined column density of CHCOOH is 2.0(1.0)
cm and the abundance ratio of CHCOOH to methyl formate (HCOOCH)
is 2.2(0.1) toward G19.61-0.23. Toward IRAS 16293 A, the
determined column density of CHCOOH is 1.6
cm and the abundance ratio of CHCOOH to methyl formate (HCOOCH)
is 1.0 both of which are consistent with abundance
ratios determined toward other hot cores. Finally, we model all known line
emission in our passband to determine physical conditions in the regions and
introduce a new metric to better reveal weak spectral features that are blended
with stronger lines or that may be near the 1-2 detection limit.Comment: 28 pages, 8 figures, accepted for publication in the ApJ; Revised
citation in session 2, references remove
Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy
<p>Abstract</p> <p>Background</p> <p>Hearing loss is common following chemoradiotherapy for children with medulloblastoma. Compared to photons, proton radiotherapy reduces radiation dose to the cochlea for these patients. Here we examine whether this dosimetric advantage leads to a clinical benefit in audiometric outcomes.</p> <p>Methods</p> <p>From 2006-2009, 23 children treated with proton radiotherapy for medulloblastoma were enrolled on a prospective observational study, through which they underwent pre- and 1 year post-radiotherapy pure-tone audiometric testing. Ears with moderate to severe hearing loss prior to therapy were censored, leaving 35 ears in 19 patients available for analysis.</p> <p>Results</p> <p>The predicted mean cochlear radiation dose was 30 <sup>60</sup>Co-Gy Equivalents (range 19-43), and the mean cumulative cisplatin dose was 303 mg/m<sup>2 </sup>(range 298-330). Hearing sensitivity significantly declined following radiotherapy across all frequencies analyzed (<it>P </it>< 0.05). There was partial sparing of mean post-radiation hearing thresholds at low-to-midrange frequencies and, consequently, the rate of high-grade (grade 3 or 4) ototoxicity at 1 year was favorable (5%). Ototoxicity did not correlate with predicted dose to the auditory apparatus for proton-treated patients, potentially reflecting a lower-limit threshold for radiation effect on the cochlea.</p> <p>Conclusions</p> <p>Rates of high-grade early post-radiation ototoxicity following proton radiotherapy for pediatric medulloblastoma are low. Preservation of hearing in the audible speech range, as observed here, may improve both quality of life and cognitive functioning for these patients.</p
Taselisib (GDC-0032), a Potent -Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations
Activating PIK3CA genomic alterations are frequent in head and neck squamous cell carcinoma (HNSCC), and there is an association between phosphoinositide 3-kinase (PI3K) signaling and radioresistance. Hence, we investigated the therapeutic efficacy of inhibiting PI3K with GDC-0032, a PI3K inhibitor with potent activity against p110α, in combination with radiation in HNSCC
Performance of two Askaryan Radio Array stations and first results in the search for ultra-high energy neutrinos
Ultra-high energy neutrinos are interesting messenger particles since, if
detected, they can transmit exclusive information about ultra-high energy
processes in the Universe. These particles, with energies above
, interact very rarely. Therefore, detectors that
instrument several gigatons of matter are needed to discover them. The ARA
detector is currently being constructed at South Pole. It is designed to use
the Askaryan effect, the emission of radio waves from neutrino-induced cascades
in the South Pole ice, to detect neutrino interactions at very high energies.
With antennas distributed among 37 widely-separated stations in the ice, such
interactions can be observed in a volume of several hundred cubic kilometers.
Currently 3 deep ARA stations are deployed in the ice of which two have been
taking data since the beginning of the year 2013. In this publication, the ARA
detector "as-built" and calibrations are described. Furthermore, the data
reduction methods used to distinguish the rare radio signals from overwhelming
backgrounds of thermal and anthropogenic origin are presented. Using data from
only two stations over a short exposure time of 10 months, a neutrino flux
limit of is
calculated for a particle energy of 10^{18}eV, which offers promise for the
full ARA detector.Comment: 21 pages, 34 figures, 1 table, includes supplementary materia
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