Low frequency pressure oscillation study, phase 1 Interim study

Characteristics of low frequency pressure oscillations in Apollo spacecraft engine

Oasis Inter-Rater Reliability and Reimbursement: A Study of Inter-rater Reliability of the Outcome and Assessment Information Set (OASIS): Its Effects on the Home Health Resource Group (HHRG) and Reimbursement

One of the outcomes of the initial Outcome and Assessment Information Set (OASIS) is to establish a level of reimbursement through the Medicare Prospective Payment System (PPS). Several inter-rater reliability (IRR) studies have noted differences in responses to individual questions within the OASIS but little is known about how variations in scoring might affect the final reimbursement projection. In a one-way repeated measures design study, the OASIS was completed on 52 patients by both an RN and a PT within a 24-hour timeframe and the projected reimbursement rates were compared. Fifty-four percent of the outcomes of the assessment pairs were identical; differences in the remaining 46% were equally divided between RNs and PTs in projecting a higher reimbursement rate and with similar distributions. The mean difference in projected reimbursement rates was $16.43 per episode with no significant difference between the PT and RN Home Health Resource Group (HHRG) distributions

Beyond Supplier Relationship Management

In an effort to determine the sources of dysfunction that affect the integrity of supply in the pharmaceutical and medical device industry, a research collaboration was created by the academia, business practitioners and regulators. The research used a multi-stage effort that relied on the DMADV (define, measure, analyze, develop, and verify) approach to identify and propose solutions for key issues influencing the reliability of supply chains in an effort to improve existing processes of the participating firms. The data was collected over 3 years and involved 41 executives from 25 participating firms that had either Fortune 500 or Fortune 100 status with median revenues of $7.3 billion, The study found that conventional wisdom about Supplier Relationship Management (SRM) is not working as intended due to the following issues: (1) A top-down mentality within the buying organization; (2) A lack of purposeful engagement with suppliers; (3) A lack of robust internal alignment and (4) The ‘dark side’ of a close relationship with suppliers/customers. The research also identified two significant shifts in the current conceptualization of SRM practices. The first paradigm shift was: From “our suppliers are causing the problems” to “we are causing the problems”. The next paradigm shift was: From “Suppliers are suppliers” to “Suppliers are customers first”. Finally, the research proposes a set of Good Supply Practices to increase manufacturers’ confidence in their products. The solutions include practices such as: robust internal alignment, purposeful transparency; comprehensive supplier qualification and manufacturer self-qualification

Asymmetry After Hip Fracture: A Multi-factorial Problem

Background and Purpose: Sit-to-stand (STS) and static standing mechanics are related to fall risk and function after hip fracture. Often, these patients avoid weight bearing on the fracture side after rehabilitation. The purpose of this study was to use a novel clinically-relevant protocol to examine standing and STS vertical ground reaction force (vGRF) in light of perceptual measures of loading symmetry and muscle torque production in this population. Methods: A person post hip fracture performed 3 different STS conditions and 2 simple load-matching tasks. Motion, force plate, and perceptual data on weight distribution and load were collected. Findings: Standing and STS asymmetry were not explained by strength. A perceptual issue may be limiting performance progress in achieving symmetry. Clinical Relevance: Active task-specific training, augmented by attention to perception of movement, load, or strength, may assist in attaining symmetry in STS. Conclusion: Some patients may benefit when mechanical and perceptual performances are considered together

The Benefits of the Arkansas Rice Check-Off Program

As margins are reducing for agricultural producers there is a concerted effort to analyze all costs. One such cost for rice producers in Arkansas is their contribution to the Rice Check-off Program. This study analyzes the cost-benefit ratio of funds contributed by Arkansas rice producers and the holistic (both economic and environmental) benefits they receive. This study analyzes just five of the many programs the Rice Check-off Program invests in through the University of Arkansas System Division of Agriculture (UASDA) and suggests that every dollar invested generated an average return of $28.49 between 2002–2018 ($70.45 when ecosystem benefits are included). That being said, our benefit-cost ratios of 28.49 to 1 and 70.45 to 1, are conservative estimates as we are comparing the total Rice Checkoff funding provided to the UASDA to the benefits of just five of its funded programs. These same investments have resulted in an increase in the rice supply sufficient enough to feed 4.15 million people annually. Rice Check-off funds have consistently provided substantial benefits from their investments

The Benefits of the Arkansas Rice Check-Off Program

As margins are reducing for agricultural producers there is a concerted effort to analyze all costs. One such cost for rice producers in Arkansas is their contribution to the Rice Check-off Program. This study analyzes the cost-benefit ratio of funds contributed by Arkansas rice producers and the holistic (both economic and environmental) benefits they receive. This study analyzes just five of the many programs the Rice Check-off Program invests in through the University of Arkansas System Division of Agriculture (UASDA) and suggests that every dollar invested generated an average return of $28.49 between 2002–2018 ($70.45 when ecosystem benefits are included). That being said, our benefit-cost ratios of 28.49 to 1 and 70.45 to 1, are conservative estimates as we are comparing the total Rice Checkoff funding provided to the UASDA to the benefits of just five of its funded programs. These same investments have resulted in an increase in the rice supply sufficient enough to feed 4.15 million people annually. Rice Check-off funds have consistently provided substantial benefits from their investments

Phylogeography of the Solanaceae-infecting Basidiomycota fungus Rhizoctonia solani AG-3 based on sequence analysis of two nuclear DNA loci

<p>Abstract</p> <p>Background</p> <p>The soil fungus <it>Rhizoctonia solani </it>anastomosis group 3 (AG-3) is an important pathogen of cultivated plants in the family Solanaceae. Isolates of <it>R. solani </it>AG-3 are taxonomically related based on the composition of cellular fatty acids, phylogenetic analysis of nuclear ribosomal DNA (rDNA) and beta-tubulin gene sequences, and somatic hyphal interactions. Despite the close genetic relationship among isolates of <it>R. solani </it>AG-3, field populations from potato and tobacco exhibit comparative differences in their disease biology, dispersal ecology, host specialization, genetic diversity and population structure. However, little information is available on how field populations of <it>R. solani </it>AG-3 on potato and tobacco are shaped by population genetic processes. In this study, two field populations of <it>R. solani </it>AG-3 from potato in North Carolina (NC) and the Northern USA; and two field populations from tobacco in NC and Southern Brazil were examined using sequence analysis of two cloned regions of nuclear DNA (pP42F and pP89).</p> <p>Results</p> <p>Populations of <it>R. solani </it>AG-3 from potato were genetically diverse with a high frequency of heterozygosity, while limited or no genetic diversity was observed within the highly homozygous tobacco populations from NC and Brazil. Except for one isolate (TBR24), all NC and Brazilian isolates from tobacco shared the same alleles. No alleles were shared between potato and tobacco populations of <it>R. solani </it>AG-3, indicating no gene flow between them. To infer historical events that influenced current geographical patterns observed for populations of <it>R. solani </it>AG-3 from potato, we performed an analysis of molecular variance (AMOVA) and a nested clade analysis (NCA). Population differentiation was detected for locus pP89 (Φ_{<it>ST </it>}= 0.257, significant at P < 0.05) but not for locus pP42F (Φ_{<it>ST </it>}= 0.034, not significant). Results based on NCA of the pP89 locus suggest that historical restricted gene flow is a plausible explanation for the geographical association of clades. Coalescent-based simulations of genealogical relationships between populations of <it>R. solani </it>AG-3 from potato and tobacco were used to estimate the amount and directionality of historical migration patterns in time, and the ages of mutations of populations. Low rates of historical movement of genes were observed between the potato and tobacco populations of <it>R. solani </it>AG-3.</p> <p>Conclusion</p> <p>The two sisters populations of the basidiomycete fungus <it>R. solani </it>AG-3 from potato and tobacco represent two genetically distinct and historically divergent lineages that have probably evolved within the range of their particular related Solanaceae hosts as sympatric species.</p

Avalanches in self-organized critical neural networks: A minimal model for the neural SOC universality class

The brain keeps its overall dynamics in a corridor of intermediate activity and it has been a long standing question what possible mechanism could achieve this task. Mechanisms from the field of statistical physics have long been suggesting that this homeostasis of brain activity could occur even without a central regulator, via self-organization on the level of neurons and their interactions, alone. Such physical mechanisms from the class of self-organized criticality exhibit characteristic dynamical signatures, similar to seismic activity related to earthquakes. Measurements of cortex rest activity showed first signs of dynamical signatures potentially pointing to self-organized critical dynamics in the brain. Indeed, recent more accurate measurements allowed for a detailed comparison with scaling theory of non-equilibrium critical phenomena, proving the existence of criticality in cortex dynamics. We here compare this new evaluation of cortex activity data to the predictions of the earliest physics spin model of self-organized critical neural networks. We find that the model matches with the recent experimental data and its interpretation in terms of dynamical signatures for criticality in the brain. The combination of signatures for criticality, power law distributions of avalanche sizes and durations, as well as a specific scaling relationship between anomalous exponents, defines a universality class characteristic of the particular critical phenomenon observed in the neural experiments. The spin model is a candidate for a minimal model of a self-organized critical adaptive network for the universality class of neural criticality. As a prototype model, it provides the background for models that include more biological details, yet share the same universality class characteristic of the homeostasis of activity in the brain.Comment: 17 pages, 5 figure