The activity of proliferation and apoptosis of thyrocytes in the thyroid tissue of patients of nodular goiter with autoimmune thyroiditis considering the polymorphism of the BCL-2 (RS17759659), CTLA-4 (RS231775), APO-1/FAS (RS2234767) genes

Nodular goiter with autoimmune thyroiditis is one of the most important problems of modern endocrinology, with inadequately studied etiological and pathogenic mechanisms of development. It is characterized by the lack of objective and reliable diagnostic methods, effective treatment methods, uncertain therapy or indications for the choice of treatment methods. A total we have examined 125 patients who were operated for a nodular endemic goiter with autoimmune thyroiditis. Investigated the activity of proliferation and apoptosis of thyrocytes in the thyroid tissue of patients of nodular goiter with autoimmune thyroiditis considering the polymorphism of the bcl-2 (rs17759659), ctla-4 (rs231775), apo-1/fas (rs2234767) genes. The expression/density markers - Fas/ FasL, Bcl-2, p53 and Ki-67 on the thyrocytes in the lymphoid infiltration and destruction areas, as well as in normal thyroid tissue (as a control) were studied. The number of immunoreactive cells, which expressed the above-mentioned regulating apoptosis and proliferation markers in NGAIT patients, depending on the genes polymorphism BCL-2 (rs17759659), CTLA-4 (rs231775) and APO-1/Fas (rs2234767) were counted. It was found that in NGAIT patients a few links of programmable thyroid cell killing of Fas-induced apoptosis were activated, and associated with the polymorphic cite of BCL-2 (rs17759659) gene and almost 6 times weaker with CTLA-4 (rs231775) gene, through enhanced expression of Fas and Fas L on the cells surface in lymphoid infiltration and destruction areas (stronger in GG genotype carriers of BCL2 gene)

Piezoelectric, dielectric and pyroelectric properties of 0-3 ceramic-polymer composites

The circular samples of composites were made from PZT ceramic grains dispersed in polymers (epoxy or rubber). Pressure dependencies of the hydrostatic piezoelectric coefficient dh and permittivity ε were measured in the range up to 60 MPa. The hydrostatic strain coefficient dh, the hydrostatic voltage coefficient gh and figure of merit dh·gh were determined using the static method. The pressure dependence of the hydrostatic coefficients was measured for several successive cycles. Experimental dependence of the charge on pressure and temperature was fitted by multi parameter function. The pressure and temperature dependencies of the hydrostatic dh and pyroelectric p3 coefficients were determined. It was found that the hydrostatic strain coefficient dh and hydrostatic voltage coefficient gh decreased and pyroelectric coefficient p3 increased with pressure at constant temperature.DFG [1102]; ICTP programme for Training and Research in Italian Laboratories (TRIL); German Bundesministerium fur Bildung und Forschung; Czech Republic MEYS Grants [ME492, LA242]; SAIL (CSR), Govt. of India; CERN-RFBR Grants [08-02-91009, 12-02-91500]; Portuguese FCT - Fundacao para a Ciencia e Tecnologia [CERN/FP/109323/2009, CERN/FP/116376/2010, CERN/FP/123600/2011]; MEXT; JSPS [18002006, 20540299, 18540281]; Daiko Foundation; Yamada Foundation; DFG cluster of excellence 'Origin and Structure of the Universe'; EU FP7 (HadronPhysics3) [283286]; Israel Science Foundation; Polish NCN Grant [DEC-2011/01/M/ST2/02350

Spin alignment and violation of the OZI rule in exclusive omega and phi production in pp collisions

Exclusive production of the isoscalar vector mesons omega and phi is measured with a 190 GeV/c proton beam impinging on a liquid hydrogen target. Cross section ratios are determined in three intervals of the Feynman variable x(F) of the fast proton. A significant violation of the OZI rule is found, confirming earlier findings. Its kinematic dependence on xF and on the invariant mass M-pV of the system formed by fast proton p(fast) and vector meson V is discussed in terms of diffractive production of p(fast) V resonances in competition with central production. The measurement of the spin density matrix element rho(00) of the vector mesons in different selected reference frames provides another handle to distinguish the contributions of these two major reaction types. Again, dependences of the alignment on x(F) and on M-pV are found. Most of the observations can be traced back to the existence of several excited baryon states contributing to omega production which are absent in the case of the phi meson. Removing the low-mass M-pV resonant region, the OZI rule is found to be violated by a factor of eight, independently of x(F). (C) 2014 CERN for the benefit of the COMPASS Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).DFG [1102]; ICTP programme for Training and Research in Italian Laboratories (TRIL); German Bundesministerium fur Bildung und Forschung; Czech Republic MEYS Grants [ME492, LA242]; SAIL (CSR), Govt. of India; CERN-RFBR Grants [08-02-91009, 12-02-91500]; Portuguese FCT - Fundacao para a Ciencia e Tecnologia [CERN/FP/109323/2009, CERN/FP/116376/2010, CERN/FP/123600/2011]; MEXT; JSPS [18002006, 20540299, 18540281]; Daiko Foundation; Yamada Foundation; DFG cluster of excellence 'Origin and Structure of the Universe'; EU FP7 (HadronPhysics3) [283286]; Israel Science Foundation; Polish NCN Grant [DEC-2011/01/M/ST2/02350

Measurement of the W boson mass

International audienceThe W boson mass is measured using proton-proton collision data at $\sqrt{s}$ = 13 TeV corresponding to an integrated luminosity of 1.7 fb$^{−1}$ recorded during 2016 by the LHCb experiment. With a simultaneous fit of the muon q/p$_{T}$ distribution of a sample of W → μν decays and the ϕ$^{*}$ distribution of a sample of Z → μμ decays the W boson mass is determined to be${m}_w=80354\pm {23}_{\mathrm{stat}}\pm {10}_{\mathrm{exp}}\pm {17}_{\mathrm{theory}}\pm {9}_{\mathrm{PDF}}\mathrm{MeV},$where uncertainties correspond to contributions from statistical, experimental systematic, theoretical and parton distribution function sources. This is an average of results based on three recent global parton distribution function sets. The measurement agrees well with the prediction of the global electroweak fit and with previous measurements.[graphic not available: see fulltext