Etiology and Treatment of Childhood Peptic Ulcer Disease in Taiwan: A Single Center 9-Year Experience

Background/PurposePeptic ulcer disease (PUD) in children is relatively rare as compared with adults. This study aimed to assess the etiology, clinical and histological characteristics, and treatment of PUD in children.MethodsAll children aged < 18 years with an endoscopic diagnosis of PUD were enrolled in a tertiary referral center. The demographic data, clinical, endoscopic, and histological findings were compared between patients with different causes of PUD.ResultsFrom 1234 endoscopic examinations, 67 (5.4%) children (median age, 11.4 years) with gastric ulcer (GU; n = 27) or duodenal ulcer (DU; n = 40) were included. Thirty-two (47.7%) of them had Helicobacter pylori infection and 11 (16.5%) had previous use of non-steroidal anti-inflammatory drugs (NSAIDs). Non-H. pylori, non-NSAID PUD was found in 24 (35.8%) patients. Children with H. pylori-related PUD had a significantly higher mean age, antral chronic inflammatory score, rate of familial PUD, and presence of DU and nodular gastritis than those with NSAID-related and non-H. pylori, non-NSAID PUD (p < 0.01). In contrast, children with NSAID-related PUD had a higher rate of upper gastrointestinal bleeding, associated with acute febrile disease, than those with H. pylori-related and non-H. pylori, non-NSAID PUD (p < 0.05). All but two patients with non-H. pylori, non-NSAID PUD were disease free after H. pylori eradication and proton pump inhibitor treatment for 1–2 months.ConclusionIn children, H. pylori-related PUD is associated with familial peptic ulcer and the presence of DU. However, short-term NSAID use is correlated highly with GU. The outcome of childhood PUD is good

The Viscosity of Asphaltene- Containing Oil

Imperial Users onl

Study on inhibitory effect of Drynaria Fortunei extract on human myeloma SP20 cells.

The objective of the study was to investigate the inhibitory effect of Drynaria fortunei extract on human myeloma SP2 cells. Three different total extracts of Drynaria fortunei were obtained by reflux extraction method using different organic solvents including ethanol, methanol and petroleum ether. Their anticancer activities on SP20 cells were tested, and the maximum inhibition rate was obtained. The inhibitory effects on tumour cells at 12 h, 24 h, 36 h and 48 h were tested, and the inhibition curves at different time periods were plotted. The results showed that the methanol and ethanol extracts have similar inhibition rates at 24 h, which are around 55%. On the other hand, the maximum inhibition rate of petroleum ether extract is only 36% within 24h. Moreover, within the time periods of 36 h and 48 h, its inhibition rates are all below 10%.Keywords: Drynaria fortunei, Flavonoid compounds, Mouse SP2/0 tumour, Inhibitory

Creating a High School Culture of College-Going: The Case of Washington State Achievers

Outlines preliminary studies of an initiative to integrate high school reform, early college information, scholarships, and mentoring in a comprehensive approach to reducing inequality and expanding low-income students' access to higher education

Forecasting Mango and Citrus Production in Nigeria: A Trend analysis

This paper provides the prediction of future production of citrus and mango in the medium term up to 2010. The prediction was based on the assumptions that past trends (area planted and yield) and existence of normal weather pattern will hold. Time trend model with specific emphasis on growth model was employed. The analysis delineated three different eras (period between 1961 and 2003, 1986 – 2003, and 1991-2003). These eras were used to simulate the different policy regimes of Regulation, Structural Adjustment era and Liberalization era. In general, output of citrus and mango maintained upward trend over the years. However, the growth rate was highest for the era including Structural Adjustment. Following from this, output predictions over the medium term are highest for the analysis with Structural Adjustment era.Mango; Citrus; Production; Yield; Prediction; Trend analysis & Nigeria;

Lipoleiomyoma of the Uterus

Lipoleiomyomas are uncommon benign neoplasms of uterus consisting of variable portions of mature lipocytes and smooth muscle cells. These tumours generally occur in asymptomatic obese perimenopausal or menopausal women. In this paper, a case of lipoleiomyoma uteri in a 53-year old menopausal woman is presented.peer-reviewe

A brief review of self-asphyxial risk-taking behaviour in adolescents

Adolescence is often viewed as a time for experimentation and risk-taking behaviour. For instance, when I was a teenager, my friends and I used to occasionally play a game that we called ‘Headrush’ where we would have our breathing temporarily stopped by someone holding onto our chests after a deep expiration and hyperventilation (so that we could not breathe). It induced feelings of light-headedness and dizziness followed by temporary unconsciousness (usually lasting 10 to 15 seconds). I did it twice and on both occasions I felt as though I had lived a whole other life while I was unconscious. I cannot remember exactly why I had engaged in such a potentially life-threatening behaviour except that all my friends were doing it

Lactose hydrolysis by immobilized whole cells of K. lactis CBS 2357 : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Bioprocess Engineering at Massey University

The application of immobilized yeast for lactose hydrolysis was investigated. The enzyme stability was tested as a function of pretreatment. The stability of K. lactis CBS 2357 cells after treatment with glutaraldehyde (GA) and the β-galactosidase activity of whole cells after immobilization in alginate bead and corn particles were studied. Permeabilization using ethanol and chloroform (10% and 2%, respectively) at 37 °C and 120 rpm for 5 min, followed by stabilization with 10 mM glutaraldehyde at 30 °C for 1 hour with gently shaking deactivated 2.5% of the initial whole cells β-galactosidase activity, tested with the ONPG method. The glutaraldehyde treatment could significantly maintain β-galactosidase activity in phosphate buffer pH 6.5 containing 0.1 mM MnCl2. Manganese and potassium ions in the Mn-Buffer were found to be essential to enhance the activity. The biomass activity of GA stabilized cells in Mn-Buffer can be maintained above 70% during 72 hours of incubation at 30 °C. An increase of incubation temperature from 30 to 37 °C deactivated 10% of biomass activity after 72 hours. Direct stabilization of alginate biocatalyst with glutaraldehyde caused a significant reduction of β-galactosidase activity with the resulting deactivation depending on glutaraldehyde and alginate concentrations. When 40 g of biocatalyst containing 2x109 cells/g alginate was stabilized in 100 ml of 0 to 4 mM glutaraldehyde, the optimum range of glutaraldehyde concentration was between 0.5 to 1.0 mM. When this concentration range was applied to stabilize 2%- to 3%-alginate biocatalyst, the average biocatalyst activity remained within 56-74% of the initial activity. It was shown that the adsorption of K. lactis on corn particles through a "double liquid cultivation stage" followed by permeabilization of biocatalyst gave a higher activity. The activity obtained was 0.84 μmol lactose hydrolyzed /min/g biocatalyst under the conditions tested. This activity was about 5 times higher than the case without permeabilization and about 2 times higher than that of the permeabilized biocatalyst prepared with a "single liquid cultivation stage". When tested in the packed-bed reactor, during the initial stages the degree of hydrolysis (d.h.) was 45% within the operational conditions tested. Free enzyme was detected during the first 5 hours of operation, especially when non-stabilized corn biocatalyst was used. After 5 hours, free enzyme was no longer detected in the reactor outlet, suggesting that direct adsorption might have rendered good cell confinement inside the corn particles

Safe Laparoscopic Removal of a 3200 Gram Fibroid Uterus

Open laparotomy may be avoided in many cases requiring hysterectomy for benign disease